Investigating a microRNA that may protect the brain after a stroke
Official title: miR-21 induced neuroprotection after stroke
Funded at Wm S. Middleton Memorial Veterans Hosp · NIH-10948905 · Data updated 2026-11-12
This study is looking at how a tiny molecule called miR-21 might help protect the brain and improve recovery after a stroke, using mice to see if boosting miR-21 levels can reduce brain damage and help with movement.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wm S. Middleton Memorial Veterans Hosp NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | October 1, 2021 |
| Project end | September 30, 2025 |
| Funding year | 2025 |
| NIH project number | 5I01BX005127-04 |
| Project ID | NIH-10948905 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults who have experienced a stroke and are looking for new therapeutic options to enhance recovery.
✕Less likely to help
Patients who have not suffered a stroke or those with conditions unrelated to stroke may not benefit from this research.
What this research studies
This research focuses on the role of a specific microRNA, miR-21, in providing neuroprotection following a stroke. By using a mouse model, the study aims to determine if increasing levels of miR-21 can prevent brain damage and improve recovery of motor functions after a stroke. The researchers will apply miR-21 mimics to assess their effectiveness in reducing neurological deficits, following established criteria for stroke treatment. The findings could lead to new therapeutic strategies for stroke patients.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that significantly improve recovery outcomes for stroke patients.
How similar studies have gone: Previous studies have shown promising results with similar approaches in animal models, indicating potential for success in human applications.
Where this research is happening
-
Wm S. Middleton Memorial Veterans Hosp
Madison, United States Active
Researchers
- Principal investigator: Vemuganti, Raghu — Wm S. Middleton Memorial Veterans Hosp
- Study coordinator: Vemuganti, Raghu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.