Finding therapies to prevent brain damage and promote recovery after brain injuries.
BLRD Research Career Scientist Award Application
['FUNDING_OTHER'] · WM S. MIDDLETON MEMORIAL VETERANS HOSP · NIH-11101285
This study is looking at new treatments to help people recover better after a traumatic brain injury or stroke by testing a mix of antioxidants that could protect the brain and improve movement, thinking, and mood.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WM S. MIDDLETON MEMORIAL VETERANS HOSP (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-11101285 on ClinicalTrials.gov |
What this research studies
This research focuses on developing therapies to prevent secondary brain damage and enhance recovery following traumatic brain injury (TBI) or ischemic stroke. The approach involves testing a combination of antioxidant therapies aimed at reducing oxidative stress and endoplasmic reticulum (ER) stress, which are known to contribute to neuronal death. By using a mouse model, the study will evaluate the effectiveness of these therapies on motor, cognitive, and neuropsychiatric functions. The ultimate goal is to identify a drug combination that can lead to significant improvements in neurological outcomes for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced traumatic brain injury or ischemic stroke, particularly veterans and service personnel.
Not a fit: Patients with chronic neurological conditions unrelated to TBI or stroke may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve recovery and quality of life for patients who have suffered brain injuries.
How similar studies have performed: Previous research has shown promise in using antioxidant therapies for brain protection, indicating potential for success in this approach.
Where this research is happening
MADISON, UNITED STATES
- WM S. MIDDLETON MEMORIAL VETERANS HOSP — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VEMUGANTI, RAGHU — WM S. MIDDLETON MEMORIAL VETERANS HOSP
- Study coordinator: VEMUGANTI, RAGHU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury