Finding therapies to prevent brain damage and promote recovery after brain injuries.
Official title: BLRD Research Career Scientist Award Application
Funded at Wm S. Middleton Memorial Veterans Hosp · NIH-11101285 · Data updated 2026-11-12
This study is looking at new treatments to help people recover better after a traumatic brain injury or stroke by testing a mix of antioxidants that could protect the brain and improve movement, thinking, and mood.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wm S. Middleton Memorial Veterans Hosp NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | April 1, 2021 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| NIH project number | 5IK6BX005690-05 |
| Project ID | NIH-11101285 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have experienced traumatic brain injury or ischemic stroke, particularly veterans and service personnel.
✕Less likely to help
Patients with chronic neurological conditions unrelated to TBI or stroke may not benefit from this research.
What this research studies
This research focuses on developing therapies to prevent secondary brain damage and enhance recovery following traumatic brain injury (TBI) or ischemic stroke. The approach involves testing a combination of antioxidant therapies aimed at reducing oxidative stress and endoplasmic reticulum (ER) stress, which are known to contribute to neuronal death. By using a mouse model, the study will evaluate the effectiveness of these therapies on motor, cognitive, and neuropsychiatric functions. The ultimate goal is to identify a drug combination that can lead to significant improvements in neurological outcomes for affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve recovery and quality of life for patients who have suffered brain injuries.
How similar studies have gone: Previous research has shown promise in using antioxidant therapies for brain protection, indicating potential for success in this approach.
Where this research is happening
-
Wm S. Middleton Memorial Veterans Hosp
Madison, United States Active
Researchers
- Principal investigator: Vemuganti, Raghu — Wm S. Middleton Memorial Veterans Hosp
- Study coordinator: Vemuganti, Raghu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.