Investigating how a specific protein variant protects the heart during injury.
Official title: The mechanism of cardio-protection from a sulfonylurea receptor isoform 2 splice variant (SUR2A-55) and its role in regulating ROMK activity, the putative mitochondrial ATP sensitive potassium channel
Funded at Wm S. Middleton Memorial Veterans Hosp · NIH-10946720 · Data updated 2026-11-12
This study is looking at a special protein that might help protect heart cells when blood flow is low, which could lead to better treatments for heart conditions in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wm S. Middleton Memorial Veterans Hosp NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | October 1, 2020 |
| Project end | September 30, 2026 |
| Funding year | 2025 |
| NIH project number | 5IK2BX004614-05 |
| Project ID | NIH-10946720 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to acute myocardial infarction or other cardiac ischemic events.
✕Less likely to help
Patients with non-cardiac conditions or those not experiencing ischemic heart issues may not benefit from this research.
What this research studies
This research focuses on understanding how a variant of the sulfonylurea receptor, known as SUR2A-55, can help protect heart cells during episodes of ischemia, which is when blood flow to the heart is reduced. The study aims to explore the role of this protein in regulating potassium channels in mitochondria, which are crucial for heart cell survival during stress. By using various laboratory models, the researchers will analyze the mechanisms by which this protein variant may confer cardioprotection, potentially leading to new therapeutic strategies for heart conditions. Patients may benefit from insights gained in this research that could lead to improved treatments for heart diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve heart protection during ischemic events.
How similar studies have gone: Previous studies have shown promising results in understanding mitochondrial potassium channels and their role in cardioprotection, suggesting that this approach has potential for success.
Where this research is happening
-
Wm S. Middleton Memorial Veterans Hosp
Madison, United States Active
Researchers
- Principal investigator: Ramratnam, Mohun — Wm S. Middleton Memorial Veterans Hosp
- Study coordinator: Ramratnam, Mohun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.