Investigating the long-term effects of COVID-19 on Veterans' health
Genetic predictors, pathophysiological mechanisms, and functional consequences of post-acute sequelae of SARS-CoV-2: Exercise challenge of gut microbiome and neuroinflammation in PASC
This study is looking at how Veterans feel after recovering from COVID-19, especially any ongoing symptoms like pain, tiredness, and brain fog, and it wants to see how exercise might help improve these issues by exploring changes in their gut health and brain inflammation.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wm S. Middleton Memorial Veterans Hosp NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10975908 on NIH RePORTER |
What this research studies
This research focuses on understanding the long-term symptoms experienced by Veterans after recovering from COVID-19, known as Post-Acute Sequelae of SARS-CoV-2 (PASC). It aims to identify the underlying mechanisms of these symptoms, which can include pain, fatigue, and cognitive issues, by examining the role of gut microbiome changes and neuroinflammation. The study employs an exercise challenge model to reveal how physical activity impacts these conditions, potentially leading to personalized treatment strategies. By analyzing the physiological responses during exercise, researchers hope to uncover insights that are not visible at rest.
Who could benefit from this research
Good fit: Ideal candidates for this research are Veterans who have experienced long-term symptoms following COVID-19.
Not a fit: Patients who have not had COVID-19 or do not exhibit long-term symptoms related to the virus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted treatments that alleviate the long-term symptoms of COVID-19 in Veterans.
How similar studies have performed: Previous research on chronic multisymptom illnesses has shown promise in understanding similar mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Madison, United States
- Wm S. Middleton Memorial Veterans Hosp — Madison, United States (Active)
Researchers
- Principal investigator: Cook, Dane B. — Wm S. Middleton Memorial Veterans Hosp
- Study coordinator: Cook, Dane B.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.