How a hormone may help protect insulin-producing cells in diabetes
The impact of cholecystokinin on pancreatic beta-cell survival through paracrine and pharmacologic signaling
This study is looking at how a hormone called cholecystokinin (CCK) might help protect the insulin-making cells in your pancreas from damage, especially for people with diabetes, like many Veterans, by figuring out how it works and finding new ways to keep those cells healthy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wm S. Middleton Memorial Veterans Hosp NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10921186 on NIH RePORTER |
What this research studies
This research investigates the role of cholecystokinin (CCK), a hormone produced in the pancreas, in protecting insulin-producing beta cells from cell death in diabetes. The study aims to understand how CCK and its receptors can enhance the survival of these cells, particularly under stress conditions like obesity and inflammation. By exploring the signaling pathways involved, the research seeks to identify new therapeutic strategies that could help maintain beta cell function and mass in patients with diabetes, especially among Veterans. The approach includes laboratory experiments on human islets to assess the effects of CCK on cell survival.
Who could benefit from this research
Good fit: Ideal candidates for this research are Veterans diagnosed with type 1 or type 2 diabetes who may benefit from therapies aimed at preserving beta cell function.
Not a fit: Patients without diabetes or those whose diabetes is not related to beta cell dysfunction may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that preserve insulin-producing cells, improving diabetes management and outcomes for patients.
How similar studies have performed: Previous research has shown promising results in using hormonal signaling to protect beta cells, indicating potential for success in this approach.
Where this research is happening
Madison, United States
- Wm S. Middleton Memorial Veterans Hosp — Madison, United States (Active)
Researchers
- Principal investigator: Davis, Dawn B — Wm S. Middleton Memorial Veterans Hosp
- Study coordinator: Davis, Dawn B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.