Sponsor or institution
Clinical trials and research at Ut Southwestern Medical Center
As of November 12, 2026, Find a Trial lists 1,205 NIH-funded research projects at this institution, with $654.5 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 1205NIH research projects
NIH-funded research (newest 40 of 1205)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Developing targeted therapies for Ewing sarcoma
This study is working on new treatments for Ewing sarcoma, a cancer that mainly affects kids and teens, by finding ways to target a specific protein that helps the cancer grow, so that we can offer safer and better options for those fighting this disease.
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Neural roots of how autistic adults understand word meaning
A study to understand how adults with autism process word meanings in the brain, aiming to improve language support.
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A new approach to healing NF1-related tibia fractures in children
This grant aims to understand why some NF1-related leg fractures in kids don’t heal well and to develop better treatments to help them recover without complications.
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Multi-center study on how ventilation during CPR relates to cardiac arrest outcomes
A large, real-world study will look at how ventilation during CPR affects survival after out-of-hospital cardiac arrest in adults.
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National Spina Bifida Patient Registry across the U.S.
A national registry collects health information from people with spina bifida to help doctors and families get better, more consistent care.
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MONA-LISA: Understanding Why Autoimmune Signals Turn into Lupus Over Time
A study using data and samples from people with early autoimmune signs to understand why some develop full-blown lupus and others do not.
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Understanding why some people with herpes virus encephalitis get sick more badly
We’re studying why certain people, including kids and adults, develop severe brain inflammation from herpes simplex virus and whether genetic or immune factors explain why vaccines don’t prevent it yet.
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Imaging how metastatic tumors spread inside the body
A comprehensive imaging project at UT Southwestern aims to understand how cancer cells spread to distant sites using advanced 3D imaging and tissue analysis.
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Genetic clues to why some people with RPSA variants develop congenital asplenia while others don’t
A small study will look at why certain people with RPSA gene changes develop congenital asplenia while others with the same changes do not.
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Genome-wide search for inherited IL-17 immune defects linked to chronic mucocutaneous candidiasis
A study to find the genetic causes of chronic mucocutaneous candidiasis by looking for inherited problems in the IL-17 immune pathway that affect people with CMC.
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Maximizing anti-tumor immune responses in kidney cancer
A cutting-edge program at UT Southwestern aims to speed up better immunotherapy options for kidney cancer by studying how to activate both innate and adaptive immune responses.
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PHF7 role in turning heart scar tissue back into heart muscle
A physician-scientist-in-training plans to study how PHF7 helps turn adult heart cells into heart muscle to improve healing after a heart attack.
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Understanding immediate non-IgE drug hypersensitivity reactions (MIND-HR)
A patient-focused program aims to improve how doctors diagnose and manage rapid allergic-like reactions to drugs, especially antibiotics, by studying the mechanisms and biomarkers involved.
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ecDNA in Cancer: Targeting Tumor Genetics for Better Treatments
A cancer research project is exploring how cancer genes on circular DNA outside chromosomes (ecDNA) drive aggressive tumors and how we might target them to improve treatments for patients with ecDNA-containing cancers.
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Tau strain propagation in models of Alzheimer’s disease
Researchers will study how different tau protein shapes linked to Alzheimer’s can spread in human-like models to better understand disease progression.
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Understanding how genetic changes affect development in autism and heart/placental cells
A large project will map how genetic variants linked to developmental disorders influence cell behavior in heart, brain, and placenta-related cells to better understand autism and related conditions.
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Understanding how pregnancy changes muscles during childbirth to improve pelvic floor health
A research project will study how hormones and mechanical forces during pregnancy remodel pelvic floor muscles to inform safer childbirth and reduce pelvic floor disorders.
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How COVID-19 spreads in low-resource communities
This project measures how COVID-19 moves through households and communities in low-resource countries to help shape better ways to prevent infections.
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How COVID-19 spreads and can be reduced in low-resource communities
This project measures how COVID-19 spreads within households in low-resource countries and uses that information to model how vaccines and measures like masks, school closures, and stay-at-home actions could lower infections.
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How COVID spreads in households and communities in low-resource countries
This project measures how COVID-19 moves between people in homes and communities in low-resource countries to help shape better prevention and vaccination choices.
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How cell membrane tension controls cell movement
Researchers are looking at how tension in cell membranes helps coordinate cell movement, which is important for immune responses, wound healing, and cancer spread.
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Defining neutrophil biology in pediatric Long COVID
This project looks at why some kids develop Long COVID by studying neutrophils to help find new ways to diagnose and treat the condition.
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Convergent RNA polymerase II and HIV-1 latency and reactivation
Researchers are studying how a special form of RNA polymerase II that acts in opposite directions might control HIV staying hidden and then reactivating in infected cells.
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Tumor-Niche Co-evolution in Ovarian Cancer Metastasis and Resistance
This research explores how ovarian cancer cells interact with their surrounding tissue to understand how metastasis and resistance to therapy develop, with potential to guide better treatments.
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Role of endotrophin in heart failure with preserved ejection fraction
A study to understand how endotrophin may drive HFpEF and whether blocking endotrophin could slow or stop the disease.
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Understanding how the brain learns to control actions using human brain recordings
A high-quality study in people with ADHD looks at how brain regions coordinate to adapt our behavior to changing goals.
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Optogenetic control of where tumors grow within organs
Aims to develop new genetic tools to make tumors start in specific parts of an organ, like head or tail of the pancreas, to better understand how location affects cancer behavior.
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XRN1 as a potential therapy target in lung cancer
A scientist-led program will study a cellular gene called XRN1 to see if turning it off can help treat non-small cell lung cancer.
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3D protein structure maps to identify viral pieces in the human virome
A project to use 3D protein structures to label unknown viral proteins from many people, helping doctors understand how the gut virome affects health.
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Mapping harmful shapes of tau protein in Alzheimer’s
Researchers are figuring out the different harmful shapes that the tau protein takes in people with Alzheimer’s and related brain diseases so those conditions can be detected earlier.
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B3GNT4 mutations and alpha-dystroglycanopathy biology
Researchers are studying how B3GNT4 works in brain and muscle cells to understand its possible role in a rare muscular and brain disease.
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Exploring new muscle chemistry in adults with Type 2 diabetes
A study will test a new imaging method to measure muscle metabolites in adults with Type 2 diabetes to better understand how the disease affects their muscles.
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Post-viral Guillain-Barre syndrome and genetic clues in kids
A study aims to understand why some children develop Guillain-Barre syndrome after viral infections by looking at genetic clues.
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Marginal zone B cells in health and autoimmune disease
A small NIH grant will study how a specific type of B cell (marginal zone B cells) helps fight infection and how it may drive autoimmune disease, with the goal of shaping safer, more effective immune responses.
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FLASH radiotherapy to protect spinal nerves during re-irradiation for vertebral metastases
A patient-focused look at using ultra-fast radiotherapy to reduce long-term spinal cord damage when repeating radiation for metastatic cancer near the spine.
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Skin’s power: how epidermal NADPH links skin health to whole-body metabolism
A study in mice and humans explores how redox balance in skin cells affects skin barrier function and whole-body fat metabolism, with potential implications for metabolic health.
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Targeting a Ferroptosis Defense Pathway in Pancreatic Cancer
Aimed at pancreatic cancer, this grant tests a new way to trigger cancer cell death by ferroptosis (a iron-driven form of cell death) and overcomes resistance tied to KRAS signaling.
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Establishing and Validating Outcome Measures for Craniofacial Morphea Across the Lifespan
This grant aims to create and test reliable tools to measure how craniofacial morphea affects people from childhood to adulthood.
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IgG glycosylation and endothelial FcγRIIB: understanding RA-related heart and blood vessel disease
This project looks at how rheumatoid arthritis affects blood vessels and clotting, with the goal of uncovering new ways to prevent heart and stroke risk for people with RA.
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Community-based aerobic exercise for adults with moderate to severe traumatic brain injury
A year-long aerobic exercise program is being tested to see if it can improve thinking, mood, and quality of life for adults aged 45–80 who have had moderate to severe traumatic brain injury.
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