Role of endotrophin in heart failure with preserved ejection fraction
Official title: Role of Endotrophin in the Pathogenesis of Heart Failure with Preserved Ejection Fraction
Funded at Ut Southwestern Medical Center · NIH-11464518 · Data updated 2026-11-12
A study to understand how endotrophin may drive HFpEF and whether blocking endotrophin could slow or stop the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 1, 2026 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $811,633 |
| NIH project number | 1R01HL188752-01 |
| Project ID | NIH-11464518 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with HFpEF or those at risk who could contribute samples or be considered for future trials.
✕Less likely to help
People without HFpEF or related fibroinflammatory pathways may not benefit from this specific approach.
What this research studies
This project looks at how endotrophin, a protein linked to scar and inflammation in the heart, may cause HFpEF by affecting heart cells and tissue. Researchers will use human data and mouse models to see how endotrophin activates signaling in heart cells and promotes fibrosis. They will test whether a humanized antibody that neutralizes endotrophin can improve heart function in established disease models, exploring a potential disease-modifying therapy. The work aims to map endotrophin’s role in HFpEF and evaluate if stopping it could help patients.
Why it matters
Potential benefit: If successful, this research could lead to a new therapy that slows or halts HFpEF progression by targeting endotrophin.
How similar studies have gone: Preclinical data suggest endotrophin drives HFpEF-like changes and antibody neutralization improves function in mice, supporting translation to humans.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Hill, Joseph a — Ut Southwestern Medical Center
- Study coordinator: Hill, Joseph a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.