Genome-wide search for inherited IL-17 immune defects linked to chronic mucocutaneous candidiasis
Official title: Genome-wide search for inborn errors of IL-17 immunity underlying chronic mucocutaneous candidiasis
Funded at Ut Southwestern Medical Center · NIH-11577355 · Data updated 2026-11-12
A study to find the genetic causes of chronic mucocutaneous candidiasis by looking for inherited problems in the IL-17 immune pathway that affect people with CMC.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | November 14, 2016 |
| Project end | February 28, 2027 |
| Funding year | 2026 |
| Award (this year) | $435,308 |
| NIH project number | 7R01AI127564-11 |
| Project ID | NIH-11577355 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with chronic mucocutaneous candidiasis, especially those with suspected or confirmed IL-17 immunity defects or related genetic syndromes.
✕Less likely to help
Patients without IL-17 pathway defects or unrelated immune conditions may not benefit from this specific research.
What this research studies
This NIH grant seeks to uncover genetic defects in IL-17 immunity that underlie chronic mucocutaneous candidiasis, focusing on both isolated and syndromic forms. Researchers will analyze genetic data from patients to identify mutations and mechanisms that disrupt IL-17 signaling and related immune responses. The goal is to connect specific inherited errors to how CMC develops and persists, which could guide future treatments and diagnostics. The work builds on years of prior discoveries in IL-17 biology and CMC, with a plan to address remaining questions about STAT1 GOF effects, STAT3-related pathways, and unidentified genetic causes. Participation would involve genetic analysis and possibly collaboration with patients who have CMC.
Why it matters
Potential benefit: Understanding inherited IL-17 defects could lead to better diagnostics and targeted therapies for people with CMC.
How similar studies have gone: Prior work has linked several IL-17 pathway defects to CMC, with this project aiming to solve remaining unanswered questions and identify additional genetic causes.
Where this research is happening
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Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Casanova, Jean-Laurent — Ut Southwestern Medical Center
- Study coordinator: Casanova, Jean-Laurent
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.