Developing targeted therapies for Ewing sarcoma
Targeting EWSR1-FLI1 through Functional, Structural and Chemical Approaches
This study is working on new treatments for Ewing sarcoma, a cancer that mainly affects kids and teens, by finding ways to target a specific protein that helps the cancer grow, so that we can offer safer and better options for those fighting this disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-9834547 on NIH RePORTER |
What this research studies
This research focuses on Ewing sarcoma, a type of cancer that primarily affects children and adolescents. It aims to create effective therapies that specifically target the EWSR1-FLI1 fusion protein, which is unique to Ewing sarcoma cells. The approach involves overcoming current challenges in developing these therapies, including the lack of reliable models for testing and the perception that certain proteins are difficult to target with drugs. By addressing these issues, the research seeks to provide safer and more effective treatment options for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and adolescents diagnosed with Ewing sarcoma, particularly those with metastatic disease.
Not a fit: Patients with other types of cancer or those who do not have Ewing sarcoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and less toxic treatments for Ewing sarcoma patients.
How similar studies have performed: While targeted therapies for Ewing sarcoma are still in development, similar approaches in targeting specific cancer proteins have shown promise in other malignancies.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Mcfadden, David Glenn — Ut Southwestern Medical Center
- Study coordinator: Mcfadden, David Glenn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.