PHF7 role in turning heart scar tissue back into heart muscle
Official title: Characterization of PHF7 function in mediating cardiac reprogramming - Supplement
Funded at Ut Southwestern Medical Center · NIH-11551639 · Data updated 2026-11-12
A physician-scientist-in-training plans to study how PHF7 helps turn adult heart cells into heart muscle to improve healing after a heart attack.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 15, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $75,600 |
| NIH project number | 3K08HL172012-03S1 |
| Project ID | NIH-11551639 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with cardiovascular disease or history of myocardial infarction who may benefit from regenerative approaches.
✕Less likely to help
Patients unlikely to benefit are those without heart damage or who are not candidates for cellular reprogramming therapies.
What this research studies
This grant supports a 5-year career development path for Dr. Glynnis Garry to become an independent cardiovascular physician-scientist. The work focuses on reprogramming adult heart cells to become functional cardiomyocytes, with PHF7 identified as a key activator in this process. The project combines laboratory research on cell reprogramming with a structured mentorship and career development plan at UT Southwestern to advance toward clinical translation. The ultimate goal is to enable new therapies that reduce scarring and improve heart function after myocardial infarction.
Why it matters
Potential benefit: If successful, patients who have had a heart attack could benefit from new regenerative therapies that restore heart muscle.
How similar studies have gone: Previous work shows that reprogramming strategies can activate heart muscle formation, but adult human cells remain challenging; this project builds on promising PHF7 findings.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Bann, Glynnis Garry — Ut Southwestern Medical Center
- Study coordinator: Bann, Glynnis Garry
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.