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Clinical trials and research at UMC Utrecht

• 62Clinical trials
• 32Countries

Newest trials

All recruiting trials (62)

• Cardiac risk test using breast cancer radiotherapy scans to guide decisions

  This study tests whether checking coronary artery calcium on planning CT scans can help patients with breast cancer make informed heart-risk decisions during radiotherapy planning.

  Recruiting UMC Utrecht · Copenhagen and 4 other locations · NCT07703033

• Cannabidiol as add-on therapy for children with refractory epilepsy (CBD-uN1que): an individualized N-of-1 series

  This trial tests whether CBD oil helps reduce seizures in children with hard-to-treat epilepsy, using a series of personalized N-of-1 comparisons against a placebo.

  Recruiting Phase 3 UMC Utrecht · Utrecht, Utrecht · NCT07668856

• Brain-Computer Interface to Control Digital Devices for People with High Cervical Spinal Cord Injury

  This study tests a fully implantable brain-computer interface to let people with high cervical spinal cord injuries control digital devices at home.

  Recruiting UMC Utrecht · Utrecht, Utrecht · NCT07640711

• Multicenter registry for adults with spontaneous subarachnoid hemorrhage

  This project collects detailed information from adults who had a spontaneous subarachnoid hemorrhage to see which treatments and care patterns lead to better outcomes.

  Recruiting at 9 sites UMC Utrecht · Nijmegen, Gelderland and 8 other locations · NCT07482124

• Right-time self-care advice for hip and knee osteoarthritis (e-cOAch)

  This project will test whether an online program can use regular symptom and activity reports to predict and deliver the right self-care advice about physical activity, weight, or sleep for people with hip or knee osteoarthritis.

  Recruiting UMC Utrecht · Utrecht · NCT07423858

• Chemotherapy plus adaptive MR-guided radiotherapy for esophageal adenocarcinoma

  This Phase 1 trial will see if adding adaptive MR-guided radiotherapy to perioperative chemotherapy (FLOT) before surgery helps adults with resectable esophageal or gastroesophageal junction adenocarcinoma.

  Recruiting Phase 1 UMC Utrecht · Utrecht, Utrecht · NCT07359443

• MR-guided radiotherapy dose escalation for esophageal squamous cell carcinoma

  This trial will try higher, MRI-guided radiation doses together with standard chemotherapy for adults with resectable, locally advanced esophageal squamous cell carcinoma to see if it improves tumor control before surgery.

  Recruiting Phase 1 UMC Utrecht · Utrecht, Utrecht · NCT07359417

• Adding angiotensin II to liver radioembolization to boost tumor radiation

  This trial will test whether a short intra-arterial infusion of angiotensin II given just before yttrium-90 radioembolization helps more radiation reach liver tumors and less reach healthy liver in adults with advanced or metastatic liver cancer.

  Recruiting Phase 2 UMC Utrecht · Utrecht, Utrecht · NCT07312292

• Dupilumab for early and long-term symptom relief and immune changes in prurigo nodularis

  This project will try dupilumab in adults with moderate-to-severe prurigo nodularis to see if it reduces itching and nodules and causes measurable immune changes over time.

  Recruiting UMC Utrecht · Utrecht, Utrecht · NCT07276425

• Early brain markers in newborns at risk for cerebral palsy

  This project will try a computer model to help doctors predict developmental problems in newborns with MRI-confirmed brain injuries who are at high risk for cerebral palsy.

  Recruiting at 7 sites UMC Utrecht · Paris and 7 other locations · NCT07189494

• Preserving residual hearing during cochlear implant surgery.

  This trial tests whether inserting the implant through the round window and using a straight lateral-wall electrode helps preserve remaining hearing in adults with severe sensorineural hearing loss who are receiving an Advanced Bionics cochlear implant.

  Recruiting UMC Utrecht · Utrecht · NCT07146841

• Exploring Eye Contact in Adults with Autism

  This study looks at how adults with autism make eye contact during conversations and how it affects their stress levels.

  Recruiting UMC Utrecht · Deventer, Overijssel · NCT06925308

• Intervention to Improve Eye Contact in Adults with Autism

  This study is trying out a new way to help adults with autism improve their eye contact to make social interactions easier and better.

  Recruiting UMC Utrecht · Deventer, Overijssel · NCT06924008

• Improving decision-making support for patients with cardiovascular disease

  This study is testing a new way to help patients with heart disease understand their treatment choices better by encouraging more discussion with their doctors.

  Recruiting at 2 sites UMC Utrecht · Alkmaar and 7 other locations · NCT06871514

• Is synovial proliferation in haemophilia joints active or inactive?

  This project will test whether ultrasound, MRI and elastography can tell if subclinical synovial proliferation in people with severe haemophilia is currently active so clinicians can treat earlier.

  Recruiting UMC Utrecht · Utrecht · NCT06809972

• Early palliative care consultation for people with bone metastases referred for radiotherapy

  This trial will test if offering an early hospital palliative care consultation improves quality of life and satisfaction for adults with advanced cancer and bone metastases who are referred for palliative radiotherapy.

  Recruiting at 5 sites Phase 2 UMC Utrecht · Amersfoort and 4 other locations · NCT06805396

• Examining the effects of furosemide on toxin levels in chronic kidney disease patients

  This study is testing whether the diuretic furosemide affects the levels of certain toxins in the blood and urine of people with chronic kidney disease.

  Recruiting UMC Utrecht · Utrecht, Utrecht · NCT06750575

• Supplemental screening for women with extremely dense breast tissue

  This study is testing if two new screening methods, contrast-enhanced mammography and abbreviated MRI, can help women with very dense breast tissue find breast cancer earlier than regular mammograms.

  Recruiting UMC Utrecht · Utrecht · NCT06636370

• Combining radioembolization with FTD-TPI and bevacizumab for advanced colorectal cancer

  This study is testing if a new combination of a targeted radiation treatment and two medications can help people with advanced colorectal cancer who haven't responded to other treatments.

  Recruiting Phase 2 UMC Utrecht · Utrecht · NCT06563986

• Boosting checkpoint immunotherapy with focused ultrasound histotripsy for metastatic or unresectable cancer

  This trial will test whether a single session of focused ultrasound histotripsy combined with ipilimumab and nivolumab helps adults with metastatic or unresectable cancer that has progressed after standard treatments.

  Recruiting Phase 1 UMC Utrecht · Utrecht, Utrecht · NCT06524570

• Two-fraction radiotherapy for localized prostate cancer

  This study is testing if giving radiotherapy in just two sessions instead of five can effectively treat localized prostate cancer while causing fewer side effects for patients.

  Recruiting UMC Utrecht · Utrecht · NCT06518226

• Yoga intervention for women with hormone-receptor positive breast cancer

  This study tests whether yoga can help women with hormone-receptor positive breast cancer feel less pain and stiffness while improving their overall quality of life during treatment.

  Recruiting UMC Utrecht · Utrecht · NCT06480513

• Using blood tests to guide chemotherapy in stage II colon cancer patients

  This study tests if using blood tests to check for tumor DNA can help doctors decide if stage II colon cancer patients need extra chemotherapy after surgery.

  Recruiting at 29 sites UMC Utrecht · 's-Hertogenbosch and 28 other locations · NCT06434896

• Virtual clinic for genetic counseling in inherited heart diseases

  This study is testing a new online genetic counseling service for families of people with inherited heart diseases to see if it gets more relatives involved compared to traditional in-person counseling.

  Recruiting UMC Utrecht · Utrecht, Utrecht · NCT06431425

• Artificial intelligence to find causes of angina with no blocked arteries (ANOCA)

  This project will test whether AI analysis of intracoronary ECG and Holter monitoring can help identify vasospasm or microvascular problems in people with ongoing angina but no obstructed coronary arteries.

  Recruiting UMC Utrecht · Utrecht · NCT06387693

• How the brain's two halves interact to help arm recovery after stroke

  This research will try applying inhibitory brain stimulation (cTBS) to the side of the brain opposite a recent stroke to see if it helps people with arm weakness regain movement.

  Recruiting UMC Utrecht · Utrecht, Utrecht · NCT06381388

• Examining a new wearable dialysis device for kidney disease patients

  This study is testing a new wearable dialysis device for people with end-stage kidney disease to see if it works better and is safe compared to regular dialysis methods.

  Recruiting UMC Utrecht · Modena, Modena and 2 other locations · NCT06314503

• Transcranial electrical stimulation for treating delirium

  This study is testing if a new type of brain stimulation can help people with delirium feel better and improve their brain activity.

  Recruiting at 2 sites UMC Utrecht · Nijmegen, Gelderland and 1 other locations · NCT06285721

• Exploring a new drug for rare immune-related inflammatory diseases

  This study is testing a new drug called Filgotinib to see if it can help people with rare immune-related inflammatory diseases feel better and reduce their symptoms.

  Recruiting at 6 sites Phase 2 UMC Utrecht · Amsterdam and 5 other locations · NCT06285539

• Personalized live-remote exercise training for cancer survivors

  This study tests whether a personalized online exercise program can help cancer survivors feel better and improve their fitness while dealing with fatigue, anxiety, and depression.

  Recruiting UMC Utrecht · Utrecht · NCT06270628

• Brain stimulation to improve arm recovery after a stroke

  This study will test whether short bursts of transcranial magnetic stimulation (continuous theta burst, cTBS) added to usual rehabilitation help adults who recently had a first unilateral stroke regain arm function.

  Recruiting at 13 sites UMC Utrecht · 's-Hertogenbosch and 15 other locations · NCT06265766

• Using advanced imaging techniques to assess treatment response after liver therapy

  This study is testing new imaging methods to see how well liver cancer treatment works in patients with liver metastases after they receive Selective Internal Radiation Therapy.

  Recruiting UMC Utrecht · Utrecht · NCT06232889

• Communication through a brain implant for people with locked-in syndrome

  This study is testing a brain implant that helps people with locked-in syndrome communicate by translating their brain activity into messages.

  Recruiting UMC Utrecht · Utrecht · NCT06207591

• FAPI PET/CT imaging to help diagnose CMS4 colorectal cancer

  A PET/CT imaging test using [18F]-ALF-FAPI-74 is being tried in adults with metastatic colorectal cancer who are undergoing surgery for liver metastases to see if the scan can reveal CMS4 subtype features.

  Recruiting UMC Utrecht · Utrecht, Utrecht · NCT06191120

• Understanding hand function issues in systemic sclerosis

  This study looks at how systemic sclerosis affects hand function in patients to see what causes problems and how to better manage them.

  Recruiting UMC Utrecht · Utrecht · NCT06133244

• Effectiveness of the RISE Intervention for stroke patients

  This study tests if a new program called RISE can help stroke survivors move more and reduce their risk of serious heart problems compared to standard care.

  Recruiting at 21 sites UMC Utrecht · 's-Hertogenbosch, North Brabant and 20 other locations · NCT06124248

• Using technology to improve care for pancreatic cancer patients

  This study is trying to see if sharing patient data among hospitals can help improve care and outcomes for people with pancreatic cancer.

  Recruiting UMC Utrecht · Utrecht · NCT06055010

• Using AttraX Putty to reduce pain in knee osteotomy

  This study is testing if using AttraX Putty during knee surgery can help reduce pain after the operation for people with knee osteoarthritis.

  Recruiting UMC Utrecht · Utrecht, Utrecht · NCT05992038

• Intensified treatment for major depressive disorder after first treatment failure

  This study is testing a stronger six-week treatment using esketamine nasal spray and other antidepressants for people with major depressive disorder who didn't get better with their first treatment.

  Recruiting at 8 sites Phase 3 UMC Utrecht · Innsbruck and 11 other locations · NCT05973851

• Intensified treatment for bipolar depression after first treatment failure

  This study is testing a stronger six-week medication plan for people with bipolar depression who didn't get better with their first treatment to see if it works better than the usual approach.

  Recruiting at 11 sites Phase 3 UMC Utrecht · Innsbruck and 12 other locations · NCT05973786

• Intensified treatment for schizophrenia after first treatment failure

  This study is testing if starting clozapine sooner can help people with schizophrenia who didn't respond to their first treatment feel better and improve their quality of life.

  Recruiting at 12 sites Phase 4 UMC Utrecht · Innsbruck and 12 other locations · NCT05958875

• High dose radiotherapy boost for gynecological cancers when brachytherapy isn't possible

  This study tests if a high dose of a special type of radiation treatment can help control tumors in women with gynecological cancers who can't have brachytherapy, while also looking at any side effects they might experience.

  Recruiting at 2 sites UMC Utrecht · Odense and 1 other locations · NCT05937958

• Evaluating early spinal changes in children at risk for scoliosis

  This study is trying to see how the spines of adolescent girls at risk for scoliosis and kids with a specific genetic condition change over time using MRI scans, to better understand who might develop scoliosis.

  Recruiting UMC Utrecht · Utrecht · NCT05924347

• Preventing calcification in patients with Pseudoxanthoma Elasticum

  This study is testing if a medication called etidronate can help young adults with Pseudoxanthoma Elasticum reduce harmful calcification in their arteries over two years.

  Recruiting Phase 3 UMC Utrecht · Utrecht · NCT05832580

• Effects of stenting on exercise capacity in patients with certain congenital heart defects

  This study is testing if a procedure to open blocked arteries can help people with certain heart defects, like d-TGA, ToF, and TA, exercise better.

  Recruiting UMC Utrecht · Amsterdam and 3 other locations · NCT05809310

• Treatment for calcification issues in Fahr's disease

  This study is testing if a medication called etidronate can help improve brain symptoms in people with Fahr's disease, which causes calcium buildup in the brain.

  Recruiting Phase 2 UMC Utrecht · Utrecht, Utrecht and 1 other locations · NCT05662111

• Same-day treatment for spinal metastases

  This study tests if giving patients with painful spinal cancer both surgery and radiation on the same day can help them feel better and recover faster compared to the usual treatment of surgery followed by radiation later.

  Recruiting UMC Utrecht · Utrecht · NCT05575323

• Study on complications and long-term outcomes after high-risk surgeries

  This study is trying to see how well we can predict and identify complications in patients having high-risk surgeries by monitoring them closely after their operations.

  Recruiting UMC Utrecht · Utrecht · NCT05331118

• Assessing breast reconstruction after neoadjuvant radiotherapy in breast cancer patients

  This study is testing if breast reconstruction after mastectomy works well and has fewer complications for breast cancer patients who have had radiation therapy before surgery.

  Recruiting UMC Utrecht · Bilthoven, Utrecht · NCT05216900

• Luteal phase support during IUI with mild ovarian stimulation

  This trial tests whether taking vaginal progesterone after intrauterine insemination with mild ovarian stimulation increases pregnancy and live birth rates for people with unexplained infertility over six months.

  Recruiting Phase 4 UMC Utrecht · Utrecht · NCT05080569

• Stereotactic body radiation therapy for isolated local pancreatic cancer recurrence

  This trial will test if adding stereotactic body radiation therapy (SBRT) to standard care helps people with an isolated local recurrence of pancreatic cancer live longer and have better quality of life.

  Recruiting at 3 sites UMC Utrecht · Amsterdam, North Holland and 2 other locations · NCT04881487

• Preserving erectile function during prostate cancer radiation therapy

  This study is testing a new type of radiation therapy to see if it can help men with prostate cancer keep their erectile function while receiving treatment.

  Recruiting UMC Utrecht · Utrecht, Utrecht · NCT04861194

• Knee registry for patients receiving knee treatment

  This study collects information from patients getting knee treatment at a clinic to see how their knee function, pain, and mobility change before and after treatment.

  Recruiting UMC Utrecht · Utrecht · NCT04364334

• Cohort for prostate cancer treatment evaluation and long-term outcomes

  This study is gathering information from men newly diagnosed with prostate cancer to see how different treatments work and how they affect patients over time.

  Recruiting at 2 sites UMC Utrecht · Nieuwegein, Utrecht and 1 other locations · NCT04228211

• Using Allopurinol to Protect the Brain and Heart in Newborns with Serious Heart Defects

  This study is testing if giving allopurinol to newborns with serious heart defects before and after heart surgery can help protect their brains and hearts from damage.

  Recruiting at 3 sites Phase 3 UMC Utrecht · Groningen and 3 other locations · NCT04217421

• Evaluating the impact of MR-guided radiation therapy on cancer treatment outcomes

  This study is testing how using a special type of radiation therapy with real-time imaging can improve treatment results and quality of life for adults with cancer.

  Recruiting at 14 sites UMC Utrecht · Pittsburgh, Pennsylvania and 17 other locations · NCT04075305

• Comparing early mitral valve repair to watchful waiting for asymptomatic patients with severe mitral regurgitation

  This study is testing whether early surgery to fix a leaky heart valve is better than just keeping an eye on it for people who don't have symptoms but have severe mitral regurgitation.

  Recruiting at 5 sites UMC Utrecht · Amsterdam and 5 other locations · NCT03975998

• Registry for new treatments in patients with atopic dermatitis

  This study is collecting information from people with atopic dermatitis to see how well new treatments work and how they affect other related conditions like food allergies and asthma.

  Recruiting at 14 sites UMC Utrecht · Nijmegen, Gelderland and 13 other locations · NCT03549416

• Using stem cells to treat digital ulcers in systemic sclerosis

  This study is testing whether injecting stem cells can help people with systemic sclerosis and painful digital ulcers that don't get better with regular treatments.

  Recruiting Phase 1/2 UMC Utrecht · Utrecht · NCT03211793

• A cohort for evaluating breast cancer treatments and outcomes

  This study is trying to see how different treatments for breast cancer affect patients' health, quality of life, and appearance over time.

  Recruiting at 4 sites UMC Utrecht · Almelo and 3 other locations · NCT02839863

• Evaluating treatments for severe community-acquired pneumonia in ICU patients

  This study tests different treatment options for ICU patients with severe pneumonia to see which ones work best, including special strategies for those with COVID-19.

  Recruiting at 234 sites Phase 3 UMC Utrecht · Jacksonville, Florida and 407 other locations · NCT02735707

• Evaluation of treatments for bone metastases

  This study is testing how well standard treatments work for people with bone metastases to help improve their care and quality of life.

  Recruiting UMC Utrecht · Utrecht, Utrecht · NCT02356497

Quick answers

How many clinical trials run by UMC Utrecht are recruiting right now?

62, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 32 countries. The most sites are in Netherlands (59 trials), Germany (7 trials), Italy (7 trials), United Kingdom (6 trials), Spain (6 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 6, Phase 2: 5, Phase 1: 3, Phase 4: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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