Evaluating early spinal changes in children at risk for scoliosis
Official title: Longitudinal MRI Study to Catch EARLY Scoliotic Changes of the Bone and Intervertebral Disc in Younger Sisters and Daughters of Adolescent Idiopathic Scoliosis Patients and the 22q11.2DS Population.
Run by UMC Utrecht · NCT05924347 · Data updated 2026-11-12
This study is trying to see how the spines of adolescent girls at risk for scoliosis and kids with a specific genetic condition change over time using MRI scans, to better understand who might develop scoliosis.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 8 Years to 11 Years |
| Sex | All |
| Enrollment | 120 (estimated) |
| Sponsor | UMC Utrecht Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Utrecht) |
| Status | Recruiting |
| Started | June 16, 2023 |
| Main results expected | May 2032 |
| Study ends | May 1, 2032 |
| Registry record updated | June 29, 2023 |
| Trial ID | NCT05924347 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adolescent girls aged 8-10 with a family history of scoliosis and boys and girls aged 9-11 diagnosed with 22q11.2 deletion syndrome.
✕Probably not a fit
Patients with existing spinal deformities or other syndromes associated with scoliosis may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to longitudinally assess anatomical changes in the spines of adolescent girls at increased risk for developing adolescent idiopathic scoliosis (AIS) and boys and girls with 22q11.2 deletion syndrome. The study will involve 60 participants from each cohort, monitored through MRI imaging at five different time points during their growth years. The primary focus is to identify differences in spinal development between those who do and do not develop AIS, while also implementing radiation-free imaging techniques. The study seeks to create a comprehensive dataset for understanding spinal biomechanics and maturity assessment.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and early detection of scoliosis, potentially allowing for timely interventions.
How similar studies have gone: While there have been studies on established scoliosis, this approach of assessing early spinal changes in at-risk populations is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Cohort 1: * Female, * 8, 9 or 10 years old * An older sibling, twin or parent diagnosed with AIS Cohort 2: * Diagnosed with 22q11.2DS * Girls: 8, 9 or 10 years old. * Boys: 9, 10 or 11 years old. All * No clinical signs of scoliosis at inclusion (physical examination by forward bending test and Bunnell Scoliometer assessment with a cut-off value of 7°. * Written informed consent of parents/legal representatives. Exclusion Criteria: * Contraindications for MR imaging * Early-onset scoliosis or other spinal deformities * Other syndromes or neuromuscular disease associated with scoliosis * Clinical signs of \>1cm leg length discrepancy * Other diseases or injuries, that are related to abnormal spinal growth, posture, activity levels, or scoliosis development.
Where it's running
-
UMC Utrecht
Utrecht, Netherlands Recruiting
Study contacts
- Study coordinator: Tom Schlosser
- Email: t.p.c.schlosser@umcutrecht.nl
- Phone: +31 88 75 53602
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.