Artificial intelligence to find causes of angina with no blocked arteries (ANOCA)

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Many patients with angina have no obstructive coronary stenosis, a condition called ANOCA that is linked to poor quality of life and adverse events. During invasive coronary angiography, coronary function testing (CFT) including intracoronary ECG is used to diagnose vasomotor disorders, but the ECG signs can be subtle and hard to interpret. This project combines intracoronary ECG recordings with ambulatory Holter monitoring and applies artificial intelligence to detect the electrocardiographic signs of ischemia that support a diagnosis of vasospasm or microvascular dysfunction. Participants are patients at UMC Utrecht with frequent chest discomfort despite therapy and no obstructive coronary disease on recent imaging or angiography who can provide informed consent.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Clinical indication for comprehensive coronary function testing because of persisting chest discomfort at least 2 times per week despite current medical therapy.
2. Absence of obstructive coronary artery disease with an indication for revascularization, documented by means of recent coronary computed tomography angiography (CCTA) or invasive coronary angiography (with invasive coronary pressure measurements if clinically indicated).
3. Patient is willing and able to provide written informed consent.

Exclusion Criteria:

1. Absence of chest discomfort after initiation of medical therapy.
2. Language barrier preventing sufficient understanding and communication in Dutch.

Where it's running

• UMC Utrecht
  Utrecht, Netherlands Recruiting

Study contacts

• Study coordinator: Tim P van de Hoef, MD, PhD
• Email: t.p.vandehoef@umcutrecht.nl
• Phone: +3188755555

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.