Sponsor or institution
Clinical trials and research at Roswell Park Cancer Institute Corp
As of November 12, 2026, Find a Trial lists 167 NIH-funded research projects at this institution, with $95.6 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 167NIH research projects
NIH-funded research (newest 40 of 167)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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A network for sharing data and resources in immuno-oncology.
This study is all about bringing together experts to find better ways to treat cancer by understanding why some treatments don’t work and discovering new targets for the immune system, which could lead to more personalized and effective therapies for adults.
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A network for sharing data and resources in immuno-oncology
This study is all about finding better ways to treat cancer using the body's immune system by working together with different experts to share information, which could lead to new treatments and help patients like you have more effective options.
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Targeting retrotransposons to help kids with hard-to-treat cancers like neuroblastoma
Aims to repurpose safe antiviral drugs to block retrotransposons in children with relapsed or refractory neuroblastoma to improve outcomes.
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MedSupport: Helping families overcome barriers to kids' chemotherapy medicines
This program offers extra support to parents of children with acute lymphoblastic leukemia to help them give home chemotherapy medicines more reliably.
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Innate immune cells and female lung cancer risk
A study exploring how certain immune cells in the lungs may contribute to lung cancer in young women who don’t smoke.
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Effect of ONP filler materials on how fast nicotine is delivered
This grant tests how different filler materials in oral nicotine pouches affect how quickly nicotine is released and absorbed in the mouth.
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Age-related dormancy genes in breast cancer using a worm model
A study looking at how aging affects dormant breast cancer cells to find genes that keep cancer asleep or trigger relapse.
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How AKT proteins affect prostate cancer aggressiveness
This project studies how different AKT protein forms influence the aggressiveness of prostate cancer, aiming to find targeted approaches for patients.
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AKT Isoform Activity Peptide Arrays
This grant aims to create peptide arrays that measure activity of AKT isoforms, which could help tailor cancer and metabolic disease treatments to individuals.
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Molecular clues to bladder cancer cell changes and therapy response
This NIH grant looks at how bladder cancer cells change their identity and how that affects response to treatment, with a focus on aggressive neuroendocrine variants.
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Repurposing spironolactone to treat bladder cancer inside the bladder
Aims to repurpose spironolactone as an intravesical treatment for non-muscle invasive bladder cancer to help prevent recurrence and progression.
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Understanding how cigarette and cigar products are judged when they’re new to the market
This grant studies how the law decides if a new cigarette or cigar product is allowed, and what that means for people who smoke or might start smoking.
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Targeting retrotransposons to help kids with hard-to-treat cancer
A pediatric cancer research grant explores using existing antiviral drugs to help children with relapsed neuroblastoma by turning off retrotransposons that drive cancer growth.
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Investing in software engineering to advance Bioconductor for genomic research
A grant to support Lori Kern’s work developing and spreading Bioconductor software that scientists use for genetic and genomic research.
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Coordinating and Data Management Center for Acquired Resistance to Therapy Network
A central center will organize data and resources from a cancer research network focused on how cancers develop resistance to therapy, helping researchers share tools and analyses to advance treatment.
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Improving HPV vaccination in rural primary care using proven strategies
A rural health approach tests easy, evidence-based ways to boost HPV vaccination for teens to help prevent cancer.
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Advancing Cancer Therapy with Radiation Biology Insights
A cancer research program is exploring how to maximize the benefits of radiation therapy while reducing its side effects, using advanced models to understand tumor and normal tissue responses.
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Cancer Immunoprevention Network Resource Coordinating Center
A national center will coordinate data and resources for researchers studying how the immune system can prevent cancer, helping scientists share analyses, standards, and tools.
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Survivors living with advanced cancer after durable response to immune therapy
This grant follows people who had advanced cancer and responded well to immune checkpoint inhibitors to understand what helps them stay well and how their symptoms change over time.
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Using antiviral drugs to target jumping DNA in hard-to-treat childhood neuroblastoma
Researchers are looking at whether common antiviral drugs can block jumping DNA elements to help children with relapsed or refractory high-risk neuroblastoma.
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New genome-editing technologies support to advance cancer research and treatment
A cancer center grant funds salary support for a gene editing expert who helps researchers use genome editing tools to study and treat cancer.
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Epigenetic aging and racial disparities in early-onset prostate cancer
This grant studies whether biological aging markers differ in African American men with prostate cancer and if that helps explain why they face higher risk and earlier onset.
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Understanding how lung cancer changes to resist targeted therapy
Researchers are studying why a common lung cancer drug stops working and how to block those changes to help patients keep benefiting from treatment.
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New targeted approach to kill TP53-mutant colorectal cancer
A new treatment idea aims to selectively kill colorectal cancers with TP53 mutations by using a DNA-damage strategy that becomes lethal when combined with PARP inhibitors.
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Genomics Shared Resource leadership at a cancer center
A cancer center genomics team lead is seeking support to keep a centralized genomics facility running for researchers and clinicians.
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Flow and image cytometry support for cancer research at a major cancer center
A dedicated expert in flow and image cytometry provides ongoing support to researchers at Roswell Park Comprehensive Cancer Center to accelerate cancer research projects.
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Dissecting how SETDB1 and its K867 monoubiquitination drive lung cancer
Researchers are studying a specific cancer-related gene mechanism in lung cancer to see how turning on a chemical tag on SETDB1 helps tumors grow.
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Movement is medicine in multiple myeloma: exercise-boosted immune and metabolic signals linked to treatment response
A study will look at how exercise changes immune and metabolic markers in the bone marrow of people with multiple myeloma to see if these changes predict how well treatment works.
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Understanding how vaping THC with or without nicotine affects how it works in the body
This study looks at how smoking-vape devices deliver THC and how adding nicotine changes how THC acts in the body and its effects.
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Targeting the immune system to help treat recurrent ovarian cancer
Aims to test a new approach that blocks a part of the immune system (complement) to boost anticancer immunity in people with recurrent ovarian cancer and fluid buildup.
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Disparities in Immunotherapy Outcomes for African Ancestry Cancer Patients in Community Settings
This project follows cancer patients treated with anti-PD-1/PD-L1 therapies in community clinics to understand how racial background may influence treatment results and side effects.
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Improving pediatric CAR T therapy for infant and child ALL with targeted drugs
A doctor-scientist is developing safer, more effective CAR T cell therapy for children with acute lymphoblastic leukemia by adding small molecule inhibitors.
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RB activation’s impact on the pancreatic cancer epigenome and tumor environment
This project studies how turning on a tumor suppressor called RB changes the biology of pancreatic cancer and its surrounding environment, with the goal of guiding better treatments for patients.
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Impact of Reduced-Exposure Nicotine Products on Mouth Health for High-Risk Adults
This project looks at how using reduced-exposure nicotine products might affect oral health in adults at high risk for mouth diseases.
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Enhanced targeted therapy for colorectal cancer in patients with advanced disease
A new combination approach is being tested to help people with colorectal cancer that has spread, using targeted cancer drugs together with a drug that blocks a key building block the cancer needs.
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How body weight and activity affect immune fighting cancer in advanced high-grade serous ovarian cancer
A study to understand how a patient’s body makeup and activity level influence the immune system and cancer outcomes in advanced ovarian cancer.
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Fruit-flavored e-cigarettes and smoking reduction in adults who smoke
This grant studies whether using fruit-flavored e-cigarettes helps adults who smoke reduce or quit smoking.
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Mouse models to find treatments for thinking and memory problems in Down syndrome
Researchers will build new mouse models that mimic Down syndrome to discover genes and pathways that could lead to treatments for thinking and memory problems in people with Down syndrome.
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Understanding unusual cell-cycle behavior in breast cancer to find new treatment angles
Researchers are studying how breast cancer cells can behave differently in their cell cycle, which might reveal new ways to stop the cancer from growing.
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How maternal stress-related serotonin changes affect offspring development and stress resilience
This work looks at whether changes in a mother's serotonin during stress can alter how her children develop and handle stress later in life.
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