Effect of ONP filler materials on how fast nicotine is delivered
Official title: Using a physiologically relevant model to identify the effect of filler materials on nicotine delivery from oral nicotine pouches
Funded at Roswell Park Cancer Institute Corp · NIH-11455485 · Data updated 2026-11-12
This grant tests how different filler materials in oral nicotine pouches affect how quickly nicotine is released and absorbed in the mouth.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Roswell Park Cancer Institute Corp NIH-funded |
| Lab location | 1 site (Buffalo, United States) |
| Project start | September 15, 2026 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $130,125 |
| NIH project number | 1R03DA066757-01 |
| Project ID | NIH-11455485 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patient groups; the study uses lab models to mimic mouth biology.
✕Less likely to help
There are no direct patient participants in this project.
What this research studies
Oral nicotine pouches are a new kind of tobacco product designed to deliver nicotine through the mouth rather than by smoking. The project uses a physiologically relevant model to study how the pouch filler influences nicotine release, aiming to identify materials that could change delivery speed. This work focuses on the mouth’s tissues and fluids to simulate real-life use and understanding potential addiction risk. The findings could inform regulators and manufacturers about which fillers alter nicotine exposure.
Why it matters
Potential benefit: If successful, the research could help ensure ONPs deliver nicotine in a way that is safer and more consistent, supporting evidence-based regulatory decisions and product design.
How similar studies have gone: Previous work has shown that product ingredients can alter nicotine release, but systematic testing of ONP fillers is still emerging.
Where this research is happening
-
Roswell Park Cancer Institute Corp
Buffalo, United States Active
Researchers
- Principal investigator: Page, Michelle — Roswell Park Cancer Institute Corp
- Study coordinator: Page, Michelle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.