Understanding unusual cell-cycle behavior in breast cancer to find new treatment angles
Official title: Delineating the dystopian nature of the cell cycle in cancer
Funded at Roswell Park Cancer Institute Corp · NIH-11325786 · Data updated 2026-11-12
Researchers are studying how breast cancer cells can behave differently in their cell cycle, which might reveal new ways to stop the cancer from growing.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Roswell Park Cancer Institute Corp NIH-funded |
| Lab location | 1 site (Buffalo, United States) |
| Project start | June 3, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $534,959 |
| NIH project number | 5R01CA267647-05 |
| Project ID | NIH-11325786 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with breast cancer, especially those whose tumors show altered cell-cycle regulation or resistance to standard therapies, may benefit from the findings.
✕Less likely to help
If a patient's cancer does not involve the non-canonical cell-cycle states studied, direct benefits may be limited.
What this research studies
This project looks at breast cancer cell lines to map non-traditional cell-cycle states and how these states affect tumor growth and treatment responses. Using both broad surveys and targeted experiments, the team aims to uncover alternative patterns of CDK/cyclin activity beyond the classic model. The ultimate goal is to identify new weaknesses in cancer cells that could lead to more effective therapies for patients with breast cancer.
Why it matters
Potential benefit: This work could reveal novel targets or strategies to overcome drug resistance and improve breast cancer treatments.
How similar studies have gone: Other studies have shown that cancer cell cycles can deviate from the classic model, supporting exploration of non-traditional states.
Where this research is happening
-
Roswell Park Cancer Institute Corp
Buffalo, United States Active
Researchers
- Principal investigator: Knudsen, Erik — Roswell Park Cancer Institute Corp
- Study coordinator: Knudsen, Erik
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.