Mouse models to find treatments for thinking and memory problems in Down syndrome
Generation and analysis of new mouse models to determine novel therapeutic targets for Down syndrome-associated cognitive deficits
['FUNDING_R01'] · ROSWELL PARK CANCER INSTITUTE CORP · NIH-11329125
Researchers will build new mouse models that mimic Down syndrome to discover genes and pathways that could lead to treatments for thinking and memory problems in people with Down syndrome.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ROSWELL PARK CANCER INSTITUTE CORP (nih funded) |
| Locations | 1 site (BUFFALO, UNITED STATES) |
| Trial ID | NIH-11329125 on ClinicalTrials.gov |
What this research studies
This project makes new mouse versions of the extra chromosome regions found in Down syndrome using advanced chromosome‑engineering tools. Scientists will combine duplications and targeted deletions to pinpoint which extra genes cause learning and memory problems. They will study brain biology and behavior in these mice to link specific genes or pathways to cognitive issues. The goal is to highlight targets that drug developers or future clinical studies could pursue to help people with Down syndrome.
Who could benefit from this research
Good fit: People with Down syndrome, their families, or caregivers who want to contribute clinical data, biospecimens, or join future human studies based on these findings would be ideal candidates for follow‑up participation.
Not a fit: People looking for immediate treatments or clinical care are unlikely to benefit directly because this is preclinical mouse research that may take years to translate to human therapies.
Why it matters
Potential benefit: If successful, the work could identify specific genes or biological pathways to target with therapies that improve learning and memory in people with Down syndrome.
How similar studies have performed: Mouse models with extra copies of chromosome 21 regions have previously helped identify candidate genes and pathways linked to cognition, but translating those findings into effective human treatments remains challenging.
Where this research is happening
BUFFALO, UNITED STATES
- ROSWELL PARK CANCER INSTITUTE CORP — BUFFALO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YU, EUGENE — ROSWELL PARK CANCER INSTITUTE CORP
- Study coordinator: YU, EUGENE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease