Innate immune cells and female lung cancer risk
Official title: Innate lymphoid Cells Drive Young Onset Lung Cancer Incidences in Females
Funded at Roswell Park Cancer Institute Corp · NIH-11455512 · Data updated 2026-11-12
A study exploring how certain immune cells in the lungs may contribute to lung cancer in young women who don’t smoke.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Roswell Park Cancer Institute Corp NIH-funded |
| Lab location | 1 site (Buffalo, United States) |
| Project start | August 1, 2026 |
| Project end | July 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $706,579 |
| NIH project number | 1R01CA304753-01A1 |
| Project ID | NIH-11455512 on NIH RePORTER |
Who could benefit from this research
✓Could help
Women under 50 who are at risk for LUAD or have LUAD, especially non-smokers, may benefit from potential future applications of this research.
✕Less likely to help
General population without LUAD risk factors may not directly benefit.
What this research studies
The project looks at why lung adenocarcinoma is rising in women under 50 and may involve immune cells that drive tumor growth. It uses advanced tumor analysis and single-cell sequencing to understand immune pathways, especially those related to type 2 immunity. The researchers plan to study how sex hormones might regulate these immune cells and influence cancer risk. Findings could point to new angles for prevention or early detection in women at risk.
Why it matters
Potential benefit: It could lead to better understanding of why LUAD affects younger women and identify targets for prevention or early intervention.
How similar studies have gone: Prior work shows immune cells influence LUAD, but the specific role of ILC2s in females is still being clarified.
Where this research is happening
-
Roswell Park Cancer Institute Corp
Buffalo, United States Active
Researchers
- Principal investigator: Dey, Prasenjit — Roswell Park Cancer Institute Corp
- Study coordinator: Dey, Prasenjit
Related research
Other NIH-funded projects on the same topics.
-
Blood-based markers to identify lung cancer risk in never-smokers
A researchers team at NYU School of Medicine is testing blood tests that might flag higher lung cancer risk in people who have never smoked, helping decide who might need screening.
-
Integrative Analysis of Lung Cancer Risk and Its Causes
A large, multi-part study at the University of New Mexico is exploring why lung cancer happens and how to better prevent and detect it.
-
Integrative Analysis of Lung Cancer Risk and Causes
A large NIH project is exploring how tobacco use, behavior, biology, and screening practices influence lung cancer risk and outcomes to help prevent and detect it earlier.
-
Digital health strategies to expand lung cancer screening in safety-net clinics
A funded project aims to help low-resource clinics increase the use of lung cancer screening for patients who smoke or are at risk.
-
Proteomics-guided matching of lung cancer tumors to preclinical models
This grant aims to improve how we match a patient’s lung cancer tumor to the right preclinical models using protein data.
-
Optimizing lung cancer care with smart tools for prevention, early detection, treatment, and survivorship
A U01 grant using AI and biomarkers to improve lung cancer prevention, screening, treatment, and survivorship care for people at risk or living with lung cancer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.