How body weight and activity affect immune fighting cancer in advanced high-grade serous ovarian cancer
Official title: Elucidating the impacts of body composition and physical activity on anti-tumor immunity and cancer control in advanced stage high-grade serous carcinoma
Funded at Roswell Park Cancer Institute Corp · NIH-11344511 · Data updated 2026-11-12
A study to understand how a patient’s body makeup and activity level influence the immune system and cancer outcomes in advanced ovarian cancer.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Roswell Park Cancer Institute Corp NIH-funded |
| Lab location | 1 site (Buffalo, United States) |
| Project start | June 1, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $713,312 |
| NIH project number | 1R37CA312294-01 |
| Project ID | NIH-11344511 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with advanced high-grade serous ovarian cancer who are undergoing treatment or in survivorship and can provide clinical data or samples.
✕Less likely to help
Patients not able to participate due to medical contraindications or lack of access to study-required data/sample collection.
What this research studies
This project explores how body composition and physical activity relate to the immune environment inside tumors and to cancer control in advanced high-grade serous ovarian cancer. Researchers will examine immune cells, especially CD8 T cells, and how lifestyle factors might modify treatment response and survival. The work will use human samples and may include observational data from patients to map immune patterns and identify potential lifestyle-related biomarkers. The findings could guide personalized care and supportive strategies during treatment.
Why it matters
Potential benefit: If successful, it could lead to lifestyle guidance and biomarker-driven approaches that improve treatment response and survival in advanced ovarian cancer.
How similar studies have gone: Prior research suggests lifestyle and immune factors influence cancer outcomes, but direct links in this cancer type need confirmation.
Where this research is happening
-
Roswell Park Cancer Institute Corp
Buffalo, United States Active
Researchers
- Principal investigator: Cannioto, Rikki — Roswell Park Cancer Institute Corp
- Study coordinator: Cannioto, Rikki
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.