Sponsor or institution
Clinical trials and research at National Institutes of Health Clinical Center (CC)
As of November 12, 2026, Find a Trial lists 630 clinical trials run by National Institutes of Health Clinical Center (CC) that are recruiting, at sites in 22 countries (most in United States (623), Mali (4), Italy (2)). 2 were first registered in the last 30 days. By phase: Phase 2 (79), Phase 1 (66), Phase 1/2 (47), Early Phase 1 (5). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 630Clinical trials
- 2New in 30 days
- 22Countries
Newest trials
All recruiting trials (newest 150 of 630)
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VLCPUFA-rich fish oil and standard DHA oil: who reaches a higher omega-3 index?
This study tests whether VLCPUFA-rich fish oil raises the blood omega-3 index more than a standard DHA-rich fish oil in healthy adults aged 18–60.
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Blood biomarkers for immune-related neuropsychiatric conditions
This study tests whether blood biomarkers can help identify neuropsychiatric disorders that may be linked to the immune system in people of any age.
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First-in-human imaging of PDE4D with [11C]JMJ-129-d2 in healthy volunteers
A new PET tracer called [11C]JMJ-129-d2 is being tested in healthy adults to see if it safely and reliably images the brain’s PDE4D enzyme and to measure how the tracer distributes in the body.
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Pain patterns in rheumatic diseases: see if pain works differently in patients and healthy people
This observational study tests how pain is experienced and measured in people with rheumatic diseases compared with healthy volunteers.
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Augmenting Parent Management Training with a Smartphone Tool
This study tests whether adding a smartphone app to parent management training helps reduce irritability and temper outbursts in kids aged 8–13 with disruptive behavior disorders.
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How healthy adults look at faces and other images with their eyes
This study tests how healthy adults direct their gaze and pay attention to visual images, including faces, to see how basic visual features influence eye movements.
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Prisoners' views on who should decide medical care if they cannot
This survey asks people in prison who they would want to make medical decisions for them if they become unable to decide for themselves.
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Can cognitive training plus psilocybin boost brain health in older adults and early Alzheimer's
This trial tests whether taking psilocybin twice, alongside a four-week cognitive training program, can improve brain function in adults 65+ with mild cognitive impairment or early Alzheimer’s and in healthy older adults.
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Dengue virus challenge in healthy adults to study immune responses
Researchers will infect healthy adults with a weakened dengue virus to see how their bodies respond and how past exposure affects the reaction.
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Test of a new PET tracer to detect fungal infections in adults
Researchers are testing a new PET tracer, 18F-Fluorocellobiose, to see if it helps find fungal infections in adults, including healthy volunteers and patients with invasive mold infections.
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Brain imaging with a new tracer to map alpha-1A receptors in healthy adults
A new PET tracer called 11C-ARMI will be tested in healthy adults to see how it highlights alpha-1A adrenoreceptors in the brain and body.
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IL-15 superagonist with or without a PSA vaccine in biochemically recurrent prostate cancer after SBRT
This study tests whether the drug N-803, alone or with a PSA-targeted vaccine, can lower PSA in men with biochemically recurrent prostate cancer after prior SBRT.
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Trisomy 8 Mosaicism Health Journey: What We’re Learning Over Time
This study tests how trisomy 8 mosaicism and related autoinflammatory conditions unfold over many years by following affected individuals and their healthy relatives.
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IL-12–producing immune cells for relapsed or refractory solid tumors
This study tests whether immune cells engineered to secrete IL-12 (IL-12 GEMys) can help the body fight relapsed or treatment‑refractory solid tumors.
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Docetaxel and SX-682 in head and neck cancers and prostate cancer
This trial tests a new drug SX-682 together with docetaxel in adults whose head and neck cancers or prostate cancer have returned or spread.
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Ketoconazole's effect on the daily cortisol rhythm in MACS
The study tests whether a single 400 mg dose of ketoconazole can modify the daily cortisol rhythm in adults with Mild Autonomous Cortisol Secretion (MACS) compared with healthy volunteers.
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PH Biorepository for Translational Research
This project collects blood samples and health information from adults with or suspected to have pulmonary hypertension to build a biorepository for future biomarker research.
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Therapy approaches for irritability in youths: active treatments vs nonactive psychoeducation
This study tests whether active psychotherapies for irritability in kids aged 8–16.5 years work better than nonactive, time-matched psychoeducation for children and their parents.
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Olfactory function and decision-making in people with HIV and/or substance use
This study tests how the sense of smell relates to decision-making in adults with HIV, substance use, both, or neither.
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Measuring PDE4B in the brain and body with a new PET tracer in healthy adults
This study tests a new PET tracer, [11C]ZTP-1, to see if it can measure PDE4B levels in healthy adults.
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Longitudinal Immunophenotyping of People with Inflammatory Bowel Disease
This study will follow adults with Crohn's disease or ulcerative colitis (and some healthy relatives) over three years to see how their immune cells change over time and how genetics and diet relate to their disease.
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CSF sample collection from people with metastatic breast cancer to see brain metastasis risk
This study tests whether spinal fluid and other samples can help predict brain metastases in adults with metastatic HER2-positive or triple-negative breast cancer who have not yet shown brain involvement.
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See if 18F-FAPI-74 PET/CT can better detect fibrosis in heart and lung disease
Researchers are testing a new PET/CT tracer, 18F-FAPI-74, to see if it can reveal early fibrotic changes in people with heart and lung diseases who are at risk for tissue scarring.
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Partial stem cell transplant for sickle cell disease and beta-thalassemia using matched donors
This study tests a partial stem cell transplant from matched donors to help people with severe sickle cell disease or beta-thalassemia see if more donor cells can persist long-term.
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TriAdeno and N-803 vaccine in early prostate cancer on active surveillance
A vaccine combo called TriAdeno plus the N-803 drug is being tested to see if it can help slow or stop growth in men with early-stage, low- to intermediate-risk prostate cancer who are being watched rather than treated right away.
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TSLPR-CART therapy for CRLF2-R/TSLPR–expressing B-ALL in adults
This study tests a CAR T-cell treatment called TSLPR-CART in adults whose B-ALL cells overexpress TSLPR and have not responded to standard therapy.
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Topical curcumin (VAS-101) for sickle cell disease: escalating doses tested
We are testing whether a skin gel containing curcumin can be safely used in adults with stable sickle cell disease to improve how red blood cells function.
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Role of theta brain waves in how kids control thoughts and actions
This study tests whether theta-frequency brain activity can reveal how children with ADHD or OCD, and healthy kids, manage thinking and behavior during tasks.
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Tirzepatide and Brain Dopamine in Alcohol Use Disorder
This study tests whether tirzepatide can alter brain dopamine responses and cue reactivity in people with alcohol use disorder and in healthy controls.
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PTH-IA treatment for Jansen's Metaphyseal Chondrodysplasia
This study will test whether twice-daily subcutaneous injections of PTH-IA are safe and can reduce abnormal PTH signaling in children and adults with Jansen's Metaphyseal Chondrodysplasia.
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Multimodal prospective approach to understand acute and chronic lung transplant rejection
This project will see if blood tests, airway sampling, imaging, and genetic analyses can identify which adults who have had or are being evaluated for a lung transplant will develop antibody‑mediated rejection and later chronic graft dysfunction.
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Intravenous brincidofovir treatment for progressive multifocal leukoencephalopathy
This trial will test whether intravenous brincidofovir given twice weekly for up to 12 weeks can help adults with progressive multifocal leukoencephalopathy (PML).
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Autologous B7-H3 CAR T Cells in Advanced Small Cell Lung Cancer and Extrapulmonary Neuroendocrine Cancer
This study tests a patient’s own B7-H3 CAR T cells to see if they can help people 18 and older whose small cell lung cancer or EPNEC has come back or hasn’t responded to prior treatment.
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Genetic factors in Turner syndrome
This project will collect whole-genome samples from people with Turner syndrome and their family members to try to find genes linked to fertility and other health problems.
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NCI CCDI registry for very rare pediatric and young adult solid tumors
This registry collects medical records and tumor genetic data from children, teens, and young adults (1 month–39 years) newly diagnosed with very rare solid tumors to help researchers learn more and guide future treatments.
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18F‑Fluorocholine PET/MRI and NeuroEXPLORER PET/CT to locate parathyroid tumors
This trial will test whether 18F‑Fluorocholine PET/MRI and NeuroEXPLORER PET/CT scans can better find overactive or cancerous parathyroid glands in adults scheduled for surgery.
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Immune profiling during first-line pirtobrutinib treatment for CLL/SLL
This will test pirtobrutinib as a first treatment for adults with CLL or SLL and see how it changes immune cells in the blood and lymph nodes.
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Thymus removal and immune aging in people with Down syndrome
This study will try to see if removing part of the thymus affects immune health over time in people aged 1 and older with Down syndrome, comparing those who had thymectomy to those who did not and to unaffected household relatives.
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LMP744 (an indenoisoquinolone) for people with recurrent glioblastoma
This trial will test whether the drug LMP744 can shrink tumors or slow progression in adults whose glioblastoma has returned after prior treatment.
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Azacitidine and abatacept for relapsed or refractory T-cell lymphoma
This study tests a combination of azacitidine and abatacept to see if it can shrink tumors in adults whose T-cell lymphoma has come back or not responded to treatment.
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Identifying genetic variants in non-obstructive azoospermia and primary ovarian insufficiency
This project will collect DNA from adults with NOA, oligospermia, or POI to try to find gene changes that may cause their infertility.
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Using CD22 CAR T-cells to extend remission after commercial CD19 CAR T-cell therapy in children, adolescents, and adults with relapsed/refractory B‑ALL
This will try giving CD22-targeted CAR T-cells to people aged 3–65 who are in remission after CD19 CAR T-cell therapy to see if it helps keep their B-ALL from coming back longer.
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CYT107 (recombinant interleukin-7) to treat Kaposi sarcoma in adults with HIV and poor T‑cell recovery
This trial tests whether CYT107, a laboratory-made interleukin-7, can shrink Kaposi sarcoma tumors in adults with HIV who have poor T‑cell recovery.
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Tofacitinib safety for people with primary Sjogren disease
This study will test whether the oral pill tofacitinib is safe and tolerable for adults with primary Sjogren disease and mild-to-moderate symptoms.
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Effects of everyday allergen and skin, airway, and gut exposures on inflammation and barrier health
This study will test whether everyday exposures from common skin and hair products, processed foods, and air change inflammation and barrier health in healthy adults aged 18 to 80.
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Baricitinib for people with STAT3‑related Hyper‑IgE (Job) syndrome who have lupus-like disease or atopic dermatitis
This trial will test whether the JAK inhibitor baricitinib can be taken safely and may reduce lupus-like symptoms or severe eczema in people aged 12 and older with STAT3-related Hyper‑IgE (Job) syndrome.
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Using a tiny high-resolution camera and mouth-cell testing to find oral precancer
This project tests whether a high-resolution microendoscope or liquid-based cytology can better find precancer and guide biopsy decisions in people aged 30–80 with visible oral lesions.
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BPL-1357 influenza vaccine by nasal spray or injection for H1N1 exposure
Test whether two doses of the BPL-1357 flu vaccine, given by nasal spray or by injection, protect healthy adults 18–55 from H1N1 after controlled exposure.
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Acamprosate for ALS with C9orf72 mutation
This study tests whether acamprosate can be safely used to see if it helps people with ALS who carry a C9orf72 mutation.
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Randomized stepped-wedge testing emapalumab for APECED enteritis
This trial will test whether emapalumab can lessen gastrointestinal symptoms in people with APECED-related enteritis.
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Hepatic Lipid Metabolism in Alcohol Use Disorder
This study tests how alcohol use disorder affects liver lipid metabolism by comparing liver biopsy transcriptomes during early and later withdrawal in adults undergoing inpatient detoxification.
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PET scan to image PDE4B in people with Alzheimer’s disease or mild cognitive impairment
We will test whether a new PET tracer can measure PDE4B levels in the brains of people aged 50 and older with Alzheimer's or mild cognitive impairment compared with healthy volunteers.
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Combining donor-derived anti-CD19 CAR-T cells with haploidentical transplant using post-transplant cyclophosphamide
This trial tests whether giving donor-derived anti-CD19 CAR-T cells together with a haploidentical bone marrow transplant using post-transplant cyclophosphamide can help adults (18–75) with high‑risk CD19+ blood cancers.
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Understanding how brain changes relate to smell disorders over time
This small, year-long study tests how brain activity and smell-related inflammation relate to different smell disorders in adults.
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Brain and reflex testing to distinguish organic and functional tics
This test uses EEG, EMG, blink reflex, and pre-pulse inhibition recordings to see if brain and reflex signals can tell apart adults with organic tics, adults with functional tics, and people without tics.
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Longitudinal multi-omic platelet volunteer program
This program will collect regular blood samples and health data from healthy adults to test how platelets, genes, and proteins change over time.
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Quadrivalent influenza HA stem vaccine (SteMos1) with or without ALFQ adjuvant in healthy adults
This will test a new quadrivalent 'stem' flu vaccine called SteMos1 given with or without the ALFQ adjuvant in healthy adults aged 18–50 who have had at least one flu vaccine since 2020.
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Fatty acid (fish oil) supplements for dermatomyositis
This trial will test whether omega‑3 (fish oil) supplements combined with a general healthy diet can help adults with mild to moderately active dermatomyositis or juvenile dermatomyositis.
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Tracking amyloid in the aging brain with PET scans
PET scans will be used to track amyloid in people aged 55 and older enrolled in the Baltimore Longitudinal Study of Aging to see if amyloid changes are linked to memory decline or other brain changes.
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ENLIGHT algorithm to find treatment options for advanced metastatic breast cancer
This test uses the ENLIGHT algorithm to try to find approved drugs that might work better for adults with triple-negative or endocrine therapy–resistant metastatic breast cancer.
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Tirzepatide for people with metabolic alcohol-associated liver disease and alcohol use disorder
This trial will test whether the weight-loss drug tirzepatide can help adults with alcohol use disorder and metabolic alcohol-associated liver disease reduce drinking, lose weight, and lower liver fat.
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Alcohol's immediate effects on brain PDE4B imaging
This will see if a controlled intravenous dose of alcohol increases PET tracer binding to PDE4B in healthy adults who drink socially.
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Esophageal string test to screen for eosinophilic esophagitis in adults of African descent with swallowing problems
This study will test whether a 1-hour esophageal string test can detect eosinophilic esophagitis in adults born in Africa (or with African parents) who have trouble swallowing.
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Individuals and families with DDX41 or similar inherited blood cancer risk variants
We will follow people and their family members who have DDX41 or other inherited blood cancer risk variants to see how often and when they develop MDS or AML and related health changes.
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Making lower-limb exoskeletons usable for children and young adults
This project will test whether a wearable leg exoskeleton, sometimes paired with electrical muscle stimulation, can help children and young adults with cerebral palsy, muscular dystrophy, spina bifida, or incomplete spinal cord injury walk and move during everyday tasks.
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rhIL-15 with dinutuximab plus irinotecan and temozolomide for relapsed or refractory neuroblastoma in children and young adults
This trial will test whether adding rhIL-15 to dinutuximab with irinotecan and temozolomide helps children and young adults (ages 3-35) whose neuroblastoma has returned or not responded to prior treatments.
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Using PET/CT Imaging to Detect Amyloidosis in Patients Treated with Anakinra
This study is testing a new imaging method to see if it can help find amyloidosis in adults with cryopyrin-associated periodic syndromes who have been treated with anakinra.
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Base editing of blood stem cells and T cells to treat CD40L‑HyperIgM syndrome (single patient)
This treatment will try to repair the CD40L gene in a man's own blood stem cells and T cells using base editing to restore immune function in CD40L‑HyperIgM syndrome.
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Understanding genetic factors in autoimmune diseases in Peru
This study is looking to see how genetic differences affect autoimmune diseases in people from Peru to better understand their health needs.
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Fostamatinib to see if it’s safe for lung transplant patients with donor-specific antibodies
This trial tests whether taking fostamatinib is safe for adults who have donor-specific antibodies after a lung transplant.
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Understanding genetic risks of immune responses after blood transfusions in sickle cell disease
This study is trying to find out how genetics affect the immune response to blood transfusions in people with sickle cell disease to help improve their treatment.
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Using baricitinib to treat Kohlmeier-Degos disease with neurological symptoms
This study is testing if the medication baricitinib can help adults with Kohlmeier-Degos disease who have neurological symptoms feel better over 24 weeks.
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Imaging brain inflammation in people with long COVID symptoms
This study is testing if a brain scan can show signs of inflammation in people aged 18 to 70 who have neurological symptoms after COVID-19, and whether a treatment called IVIg can help them feel better.
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Understanding brain changes during puberty in children
This study looks at how the brains of healthy kids aged 9 to 14 change during puberty to better understand their development.
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Vaccination against Epstein-Barr Virus in Healthy Adults
This study is testing two new vaccines for the Epstein-Barr Virus in healthy adults aged 18 to 29 to see if they can safely boost the immune response against the virus.
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Personalized T cells engineered to target TP53 or RAS mutations in blood cancers
This trial will try using a patient's own T cells, modified to recognize specific TP53 or RAS mutations, to treat adults with certain blood cancers.
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Anti-mesothelin TNhYP218 CAR T cell therapy for mesothelin-expressing solid tumors
This treatment will test whether a person's own engineered CAR T cells that target mesothelin can help adults with mesothelin-expressing solid tumors, including mesothelioma, that have returned or spread after standard therapy.
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Assessing appearance concerns in Neurofibromatosis Type 1 patients
This study is trying to understand how appearance-related concerns affect people with Neurofibromatosis Type 1 by gathering their thoughts and experiences through questionnaires and discussions.
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Imaging PDE4D in the brain and body using a new radiotracer
This study is testing a new imaging tool to see how well it can track a specific protein in the brains and bodies of healthy adults to help us understand its role in brain disorders.
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FGFR4-directed CAR T cell therapy for children and young adults with recurrent or refractory rhabdomyosarcoma
This trial will try a personalized CAR T cell treatment that targets the FGFR4 protein for people aged 3–39 whose rhabdomyosarcoma has returned or not responded after at least two prior treatments.
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Testing a new flu vaccine with and without an adjuvant in healthy adults
This study is testing a new flu vaccine with and without an added booster to see if it helps healthy adults aged 18 to 50 build a stronger immune response.
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Effects of environment on drinking behaviors in people with alcohol use disorder
This study is testing how different activities and surroundings can help people with alcohol use disorder drink less and feel better.
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Best germline DNA source to guide drug dosing after allogeneic stem cell transplant
This project will test whether blood, skin, or other tissue samples give the most reliable genetic information to guide medicine dosing for adults who receive an allogeneic stem cell transplant.
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Hormone replacement for adolescents with premature ovarian insufficiency
This study will test estrogen patches plus progesterone in girls and young women aged 11–19 with premature ovarian insufficiency to see if hormone replacement improves bone density, metabolic markers, muscle strength, and cardiovascular health.
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Investigating how a specific gene affects alcohol consumption and brain activity
This study is testing how a specific gene might influence drinking habits and brain activity in healthy adults aged 21 to 60.
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Adding lenacapavir to ART to try to shrink hidden HIV reservoirs
This study will test whether giving lenacapavir in addition to a stable ART regimen can reduce hidden HIV reservoirs in adults who have had undetectable viral loads for at least three years.
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Imaging brain protein levels in people with alcohol use disorder
This study is testing if the levels of a brain protein called PDE4B change in people with alcohol use disorder during withdrawal and after they stop drinking for a while.
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Study of childhood high blood pressure and its genetic factors
This study is trying to find out how genes affect high blood pressure in kids by looking at their health over several years to help create better treatments.
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Understanding the genetic causes of cartilage tumors and vascular anomalies
This study is trying to find out the genetic reasons behind rare conditions like Ollier disease and Maffucci syndrome that cause cartilage tumors and blood vessel issues in people aged 2 and older.
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Biorepository for people with allergic diseases
This study is collecting samples and information from people with allergies or sinus issues to help researchers learn more about these conditions and improve future treatments.
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Using soquelitinib to treat autoimmune lymphoproliferative syndrome
This study is testing if a new drug called soquelitinib can help people with autoimmune lymphoproliferative syndrome feel better and manage their symptoms.
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Understanding heart disease in young people with type 2 diabetes
This study looks at what causes heart disease in young people aged 12 to 25 with type 2 diabetes, those who are overweight, and healthy peers to see how their heart health compares over time.
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Predicting motor skill errors before they happen
This study is testing if we can predict mistakes in movement up to one second before they happen in healthy young adults to help prevent those errors.
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Exploring the effects of heavy alcohol use on oral health and saliva
This study is trying to see how heavy drinking affects oral health and inflammation in people with alcohol use disorder compared to those without it.
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Monitoring substance use and tracking relapse through smartphone data
This study is testing a smartphone app to see how tracking people's phone use and habits can help understand and prevent drug and alcohol relapse in adults.
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Understanding rare lipid disorders and their effects over time
This study is trying to understand how rare lipid disorders change over time and how they respond to treatments in people aged 10 and older.
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Testing ManNAc for treating kidney disease FSGS
This study is testing if a new oral treatment called ManNAc can help adults with kidney disease FSGS by reducing protein levels in their urine and checking how safe it is over 12 weeks.
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Improving the Desmopressin test for diagnosing Cushing Syndrome
This study is testing a new way to use the Desmopressin test to better diagnose different types of Cushing syndrome in adults who might have the condition.
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Observing how congenital myasthenic syndromes affect patients over time
This study is tracking how congenital myasthenic syndromes affect people over five years to better understand the condition and help improve future treatments.
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Understanding how social factors affect cognitive function after stroke
This study looks at how social factors, like support from family and friends, affect how well people recover mentally after having a stroke.
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Assessing the safety and infectivity of a malaria challenge agent in healthy adults
This study is testing how the malaria parasite affects healthy adults and how their immune systems respond, to help develop better vaccines.
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Gaze-Contingent Music Therapy to Help Kids with Anxiety
This study is testing if adding a special music therapy to regular talk therapy can help kids and teens with anxiety feel better.
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Genetic analysis of rare diseases in non-US populations
This study is trying to find the genetic causes of rare diseases in children and their families living outside the U.S. to improve understanding and access to testing in those areas.
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Evaluating remnants of SARS-CoV-2 in people recovering from COVID-19
This study is trying to see if people who have recovered from COVID-19 still have leftover pieces of the virus in their bodies, especially those with ongoing neurological symptoms.
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Using brain stimulation to improve learning and decision-making
This study is testing if a type of brain stimulation can help healthy adults learn better and make smarter decisions.
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Understanding blood vessel diseases and inflammation
This study is trying to understand how blood vessel diseases and inflammation are connected by looking at people with these conditions, their healthy family members, and other healthy volunteers.
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Motion Reset for preventing cybersickness during virtual reality
This project will test if Motion Reset software can reduce cybersickness in healthy adults using virtual reality.
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Screening and evaluation for substance use disorders at NIDA
This study is trying to see if people with and without substance use disorders can join future research at NIDA to help understand drug use and improve treatments.
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Testing a new drug for treatment-resistant depression
This study is testing a new drug called HNK to see if it can help people with treatment-resistant depression feel better when other medications haven't worked.
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Pupillometry to measure pain and sensory problems in people with NF1
This study will test whether the AlgometRx Nociometer, a pupillometry device, can measure pain and other sensory problems in children and adults with NF1.
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Using a new imaging agent to detect various cancers
This study is testing a new imaging agent to see if it can better detect certain cancers in adults compared to standard imaging methods.
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Exploring movement in children and young adults with cerebral palsy
This study is testing new technologies to see how children and young adults with cerebral palsy move, both with and without a robotic exoskeleton, to help improve their mobility.
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Expansion of a genetic and data repository for rare eye diseases
This study is collecting genetic and health information from people with rare eye diseases like Aniridia and Best disease, along with their family members, to help improve understanding and treatment options for these conditions.
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Preoperative targeted radiation before surgery for recurrent abdominal adrenocortical carcinoma
This study tests giving a short course of focused external beam radiation before surgery in adults whose adrenocortical cancer has come back and appears removable.
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Understanding how the brain reacts to frustration in healthy adults
This study is trying to see how the brains of healthy adults react to frustration by using special tasks and brain imaging techniques.
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Using Suvorexant to understand brain mechanisms in alcohol use disorder
This study is testing whether the sleep medication Suvorexant can help people with alcohol use disorder by looking at its effects on their brain and cravings for alcohol.
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Understanding how Staphylococcus aureus interacts with human cells using tonsil tissues
This study is testing how Staphylococcus aureus affects human cells using tonsil tissues from people having their tonsils removed to learn more about immune responses.
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Targeted alpha therapy [212Pb]VMT-Alpha-NET for SSTR-positive metastatic or inoperable GI neuroendocrine, pheochromocytoma/paraganglioma, small cell lung, kidney, and head & neck cancers
This trial will try an experimental targeted alpha-particle drug called [212Pb]VMT-Alpha-NET in adults whose metastatic or inoperable tumors show somatostatin receptor (SSTR) expression.
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Using dupilumab to help patients with hypereosinophilic syndrome who still have symptoms
This study is testing if adding dupilumab to the treatment of adults with hypereosinophilic syndrome can help reduce their ongoing symptoms.
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Understanding how the brain processes unpleasant sensations of pain and effort
This study is testing how the brains of people with chronic fatigue syndrome and healthy volunteers respond to pain and physical effort to better understand their experiences.
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Understanding the impact of mood disorders and treatment responses
This study is trying to learn more about how people with depression and bipolar disorder respond to treatment by talking to them weekly for up to 12 weeks to improve future care and predict how well medications might work.
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Targeted treatment for advanced gastrointestinal neuroendocrine tumors and pheochromocytoma
This study is testing a new drug to see if it can help people with advanced gastrointestinal neuroendocrine tumors and pheochromocytoma who have already tried other treatments.
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Genetic testing to personalize belinostat treatment for high-grade neuroendocrine carcinomas
This study is testing if genetic testing can help find the right dose of the cancer drug belinostat for people with high-grade neuroendocrine carcinomas to improve treatment results and reduce side effects.
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Understanding the natural history of Kaposi Sarcoma
This study looks at how Kaposi Sarcoma affects people with weakened immune systems, like those with HIV, by tracking their symptoms and health over time.
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Treatment for Chronic Lymphocytic Leukemia using modified T cells
This study is testing a new treatment using modified T cells to see if it can help people with chronic lymphocytic leukemia that hasn't responded to other therapies.
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Re-irradiation for recurrent glioblastoma
This study is testing a new way to safely give radiation treatment again to adults with recurring glioblastoma to see if it can improve their options after their tumors come back.
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Evaluation of secondary hemophagocytic lymphohistiocytosis and its immune mechanisms
This study is trying to understand the immune system's role in secondary hemophagocytic lymphohistiocytosis by looking closely at patients' health and blood over a year to find better treatment options.
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Does starting with a low-carb versus a low-fat diet change how much body fat you lose?
This will try whether starting with a low-carb or a low-fat diet changes body fat loss in adults with overweight or obesity over two back-to-back four-week diets.
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Base editing of blood stem cells to fix the CYBB mutation in X-linked chronic granulomatous disease.
This trial will try base-editing a person's own blood stem cells to fix a specific CYBB mutation in adult men with X-linked chronic granulomatous disease.
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Testing hymecromone in adults with interstitial lung disease
This study is testing a new medication called hymecromone to see if it can help adults with progressive interstitial lung disease feel better and improve their lung function.
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Understanding red blood cell lifespan in sickle cell disease and hemoglobin disorders
This study is trying to see how long red blood cells last in people with sickle cell disease and other blood disorders to help improve their treatment.
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Pacritinib for adults and adolescents (12+) with myelodysplastic syndromes or MDS/MPN
This study will try the oral medicine pacritinib in people aged 12 and older with MDS or MDS/MPN to see if it helps their disease.
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Collection of biological samples for research on head and neck disorders
This study is collecting biological samples from people with head and neck disorders to see how these conditions develop and find better ways to diagnose and treat them.
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Understanding RYR1-related muscle disorders
This study is looking to learn more about RYR1-related muscle disorders by tracking the health and progress of participants aged 7 and older over several years.
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Observing how the environment affects reproductive health
This study looks at how different environmental factors might affect reproductive health in people aged 8 and older, including issues like infertility and hormone problems.
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Urolithin A supplementation's effects on glucose metabolism in older adults
This study is testing if a natural supplement called Urolithin A can help older adults improve their blood sugar control and insulin response.
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Measuring how proteins are replaced in healthy adults over time
This study is testing how quickly proteins are replaced in healthy adults of different ages to see how aging affects this process.
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Understanding how acamprosate affects brain function in alcohol use disorder
This study is testing whether acamprosate can improve brain function and reduce anxiety and cravings in people with alcohol use disorder.
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Combination of a HER2-targeting vaccine and immunotherapy for advanced endometrial cancer
This study is testing a new combination treatment for advanced endometrial cancer that includes a personalized vaccine made from patients' own blood, along with other medications, to see if it helps those whose cancer has progressed after other treatments.
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Evaluating adrenal gland function using a new imaging agent in patients with hormone-related conditions
This study is testing a new imaging agent to see if it can help find adrenal tumors in adults with hormone-related conditions like hyperaldosteronism or hypercortisolism.
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Combining Lurbinectedin and Avelumab for Small Cell Carcinoma of the Bladder
This study is testing if a combination of two drugs, lurbinectedin and avelumab, can help people with small cell carcinoma of the bladder and similar tumors feel better when their cancer has come back or spread.
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Neoadjuvant chemotherapy with a vaccine for HPV-related throat cancer
This study is testing if a new vaccine combined with standard chemotherapy can help people with HPV-related throat cancer live longer and avoid radiation treatment.
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Comparing fixed and adjusted meal tests for blood glucose response
This study is testing whether giving people fixed or adjusted meal sizes affects their blood sugar levels differently during a mixed meal tolerance test.
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Monitoring for cancer risk in neurofibromatosis type 1 tumors
This study is trying to find out which harmless tumors in people with neurofibromatosis type 1 might turn into cancer so that doctors can better monitor patients at risk.
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Using ultra-low field MRI to assess brain conditions
This study is testing a new type of MRI that uses lower magnetic fields to see if it can better detect brain problems in people of all ages, including those with neurological symptoms.
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Using enasidenib to treat IDH2-mutated sinonasal and skull base tumors
This study is testing if a new drug called enasidenib can help people with rare nasal or skull base cancers that have a specific mutation and haven't responded to other treatments.
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Understanding how immune diseases affect the nervous system
This study looks at how immune diseases affect the nervous system in patients and their healthy relatives to better understand the connection between these two systems.
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Pembrolizumab plus N-803, with or without PD-L1 t‑haNK cells, for operable HPV‑negative head and neck cancer
This trial will test whether giving N‑803 with pembrolizumab, and in some patients adding PD‑L1 t‑haNK immune cells before surgery, can improve outcomes for people with HPV‑negative resectable head and neck squamous cell carcinoma.
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Combining two drugs to treat rare genitourinary tumors
This study is testing whether a combination of two drugs can help adults with rare and aggressive genitourinary tumors feel better and improve their treatment options.
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Testing PLX038 for brain and spinal cord tumors with MYC or MYCN amplifications
This study is testing a new treatment called PLX038 for adults with brain and spinal cord tumors that have specific gene changes to see if it helps improve their condition.
Showing recruiting studies first, then the newest. Describe your situation to find the ones that fit you.
Quick answers
How many clinical trials run by National Institutes of Health Clinical Center (CC) are recruiting right now?
630, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 22 countries. The most sites are in United States (623 trials), Mali (4 trials), Italy (2 trials), Turkey (Türkiye) (2 trials), Canada (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 79, Phase 1: 66, Phase 1/2: 47, Early Phase 1: 5. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.