Urolithin A supplementation's effects on glucose metabolism in older adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the impact of Urolithin A (UA), a natural nutritional supplement, on glucose metabolism in healthy adults aged 55 and older. Participants will be randomly assigned to receive either UA or a placebo over an 8-week period, with assessments of insulin secretion and other metabolic markers conducted at multiple clinic visits. The study aims to determine if UA can enhance insulin response and improve glucose control, potentially benefiting metabolic health in older adults.

Why it matters

Who can join: the full rules

* INCLUSION CRITERIA:

In order to be eligible to participate in this study, an individual must meet all of the following criteria:

* Provision of signed and dated informed consent form.
* Stated willingness to comply with all study procedures and availably for the duration of the study.
* Male or female, age \>= 55 years.
* Able to speak and read English. (We do not have ready access to interpreters of different languages at the NIA Clinical Unit).
* BMI \>= 27.
* Ability to take oral medication and be willing to adhere to the daily regimen.
* Ability to perform walking and treadmill tests without physical limitations.
* In good general health, as evidenced by medical history/physical exam/laboratory results.

EXCLUSION CRITERIA:

An individual who meets any of the following criteria will be excluded from participation in this study:

* History of diabetes requiring treatment with any glucose lowering drug(s).
* Fasting glucose \>= 126 on screening visit.
* Is on treatment with an investigational drug or other intervention within 8 weeks of enrollment.
* Hospitalization within 12 months for myocardial infarction, coronary revascularization or bypass surgery or stroke.
* History of autoimmune disease, e.g., Hashimoto s thyroiditis, Myasthenia Gravis or Rheumatoid Arthritis.
* Uncontrolled thyroid disease.
* Chronic liver disease indicated by medical history or one of the liver enzymes greater than 2 times the normal range.
* History of chronic kidney disease or GFR \<60 mL/min/1.73 m\^2.
* Anemia (defined as hemoglobin level \<12 g/dl for men or \< 11 g/dl for women).
* Poor venous access.
* Uncontrolled hypertension as judged by the Investigator.
* History of significant GI disease, e.g., IBS, Crohn s disease.
* Active cancer or has had treatment for cancer in the last 1 year.
* Medical condition requiring absolute and continuous need for long-term treatment with antibiotics, corticosteroids, immunosuppressors.
* Currently pregnant or a nursing mother due to possible changes in hormones and metabolism.
* History of, or laboratory evidence of HIV virus infection at Screening Visit.
* History of, or laboratory evidence of Hepatitis B or C at Screening Visit.
* Positive urine drug screen at Screening Visit (unless taking prescribed medication and at the discretion of the PI).
* Reports claustrophobia and/or is not eligible to have an MRI as per the MRI eligibility form.
* Weight \>= 300 lbs (MRI scanner weight limit).
* Hip or knee replacement or other medical condition that prevents MRI research scans from being performed.
* Diagnosed with cognitive impairment that clearly prevents the participant from providing informed consent.
* Current smoker or tobacco use in the past year.
* History of substance abuse, including marijuana use in the past year.
* On average, consumes more than 1 alcoholic drink per day.
* Any other condition which in the investigator s opinion may adversely affect the subject s ability to complete the study or its measures or which may pose significant risk to the subject.

Where it's running

• National Institute of Aging, Clinical Research Unit
  Baltimore, Maryland, United States Recruiting

Study contacts

• Principal investigator: Josephine M Egan, M.D. — National Institute on Aging (NIA)
• Study coordinator: Denise L Melvin, R.N.
• Email: melvinde@mail.nih.gov
• Phone: (410) 350-3924

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Pfizer medicine PF-08103402: how different doses are tolerated in healthy adults and adults with mild-to-moderate asthma

  This study tests how different amounts of PF-08103402 behave in the body and how well it is tolerated by healthy adults and adults with mild-to-moderate asthma.

  Recruiting at 2 sites Phase 1 Pfizer · New Haven, Connecticut and 1 other locations · NCT07660731

• Comparing how three adhesive dressings stay on the skin

  We will test how well three different self-adhesive dressings stick to and stay on the back of healthy adults.

  Recruiting Molnlycke Health Care AB · Schenefeld, Free and Hanseatic City of Hamburg · NCT07034014

• Focal muscle vibration to limit leg muscle weakness during reduced use

  This trial will see if a 10-day program of focal muscle vibration can limit strength loss in healthy adults whose one leg is temporarily unloaded.

  Recruiting Centre Hospitalier Universitaire de Saint Etienne · Saint-Etienne · NCT07021079

• Kidney responses to exercise in heat and whether vitamin B3 changes them.

  This project will test whether taking vitamin B3 changes how the kidneys respond when healthy, physically fit adults exercise in hot, humid conditions.

  Recruiting at 2 sites Early Phase 1 Beth Israel Deaconess Medical Center · Boston, Massachusetts and 1 other locations · NCT06983730

• Assessing the safety of inhaling xenon gas in healthy volunteers

  This study is testing if inhaling xenon gas is safe for healthy people to see if it could help in treating neurodegenerative diseases like Alzheimer's in the future.

  Recruiting Phase 1 General Biophysics LLC · Boston, Massachusetts · NCT06945614

• Brain responses to gentle ear stimulation measured with near-infrared light

  This one-visit test uses gentle ear stimulation and near-infrared head sensors to see how healthy adults' brains respond.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT06825364

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.