Understanding the natural history of Kaposi Sarcoma

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to characterize the natural history of Kaposi Sarcoma (KS), a tumor associated with the Kaposi sarcoma herpesvirus, particularly in individuals with compromised immunity such as those with HIV. Participants aged 18 and older with histologically confirmed KS will undergo physical exams, blood tests, imaging scans, and possibly biopsies to collect data on the disease's presentation, manifestations, and recurrence rates. The study will also assess the impact of KS on the immune system and overall health through longitudinal evaluations and participant-reported outcomes.

Why it matters

Who can join: the full rules

* INCLUSION CRITERIA:

Participants must have histological KS confirmed by the Laboratory of Pathology (LP), NCI.

* KS as assessed by cutaneous or oral KS lesions or other assessable KS disease.
* Age \>=18 years.
* ECOG performance status \<=4.
* Ability of participant to understand and the willingness to sign a written informed consent document.

EXCLUSION CRITERIA:

* Participants with active KSHV-associated inflammatory cytokine syndrome (KICS), multicentric Castleman disease (MCD), or primary effusion lymphoma (PEL).
* Participants with serious and/or uncontrolled severe intercurrent illness, such as opportunistic infections, that in the judgement of the investigator would preclude participation in the study.

Where it's running

• National Institutes of Health Clinical Center
  Bethesda, Maryland, United States Recruiting

Study contacts

• Principal investigator: Ramya M Ramaswami, M.D. — National Cancer Institute (NCI)
• Study coordinator: Irene B Ekwede, R.N.
• Email: irene.ekwede@nih.gov
• Phone: (240) 760-6126

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.