Understanding how Staphylococcus aureus interacts with human cells using tonsil tissues

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to investigate the interactions between Staphylococcus aureus and human cells by utilizing tonsil tissues that are typically discarded after tonsillectomy. Researchers will develop lymphoid organoid models to evaluate immune responses to the Chemotaxis Inhibitory Protein of S. aureus (CHIPS). Participants aged 2 years and older, who are scheduled for tonsil removal, will provide nasal swabs and answer health questionnaires. The study will analyze immune cell composition, antibody levels, and cytokine levels to better understand host-pathogen interactions.

Why it matters

Who can join: the full rules

* INCLUSION CRITERIA:

To be eligible to participate in this study, an individual must meet all of the following criteria:

* Aged \>=2 yrs.
* Undergoing tonsillectomy as part of their clinical care.
* Able to provide informed consent (for ages \>=18 years) or has a parent or guardian who can provide informed consent on their behalf (for ages \<18 yrs).
* Willing to allow samples and data to be stored and shared for future secondary research.
* Willing to allow future genetic testing on their biospecimens.

EXCLUSION CRITERIA:

An individual who meets any of the following criteria will be excluded from participation in this study:

* Active infection.
* Active tonsilitis.
* Pregnant.
* Diagnosed with an immunosuppressive condition or currently taking immunosuppressive medications.
* Current or past intravenous drug use.
* Any condition that, in the judgment of the investigator, may put the participant at undue risk or make them unsuitable for participation in the study

Where it's running

• National Institute of Allergy and Infectious Diseases (NIAID)
  Bethesda, Maryland, United States Recruiting
• National Institutes of Health Clinical Center
  Bethesda, Maryland, United States Recruiting

Study contacts

• Principal investigator: Michael Otto, M.D. — National Institute of Allergy and Infectious Diseases (NIAID)
• Study coordinator: Katherine Le, M.D.
• Email: katherine.le@nih.gov
• Phone: (301) 761-7166

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.