Sponsor or institution
Clinical trials and research at Mclean Hospital
As of November 12, 2026, Find a Trial lists 27 clinical trials run by Mclean Hospital that are recruiting, at sites in 2 countries (most in United States (27), Switzerland (1)). By phase: Phase 1/2 (3), Phase 2 (3), Early Phase 1 (2), Phase 2/3 (1). There are also 117 NIH-funded research projects at this institution, with $82.8 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 27Clinical trials
- 117NIH research projects
- 2Countries
Newest trials
All recruiting trials (27)
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One Day of Ultra-Accelerated TMS With a Dose of NRX-101 for Major Depression
This study tests whether a single day of rapid TMS plus NRX-101 can help people with moderate to severe depression see improvement over six weeks.
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One-Day cTBS Over the Precuneus and iTBS Over the Left PFC for Treatment-Resistant Depression
This study tests whether a one-day accelerated TMS session targeting the precuneus or the left dorsolateral prefrontal cortex can reduce depressive symptoms in adults with treatment-resistant depression, compared with sham stimulation.
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Cannabinoid-based product for gynecologic pain in endometriosis, adenomyosis, or PID
This study tests a high-CBD, hemp-derived product against placebo in adults with gynecologic pain from endometriosis, adenomyosis, or PID over one week to see if it reduces pain and related symptoms.
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Synaptic Effects of iTBS for Depression in Adults
Researchers are testing whether a brief form of brain stimulation, called iTBS, plus certain medicines, can better help adults with major depression who haven’t fully improved with standard treatments.
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How patterned magnetic pulses (cTBS) change brain wiring in depression
This study tests whether a patterned magnetic brain stimulation called continuous theta-burst stimulation (cTBS), with and without short-acting drugs, changes synaptic signaling and brain responses in people with major depression.
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Recovery Inspired Support Engagement: A 12‑week 1-on-1 program for families and friends supporting someone in recovery
A 12‑week telehealth program will test whether a one‑on‑one support program for people who support loved ones in substance use recovery is doable and acceptable.
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Measuring the consequences of substance use
We will try a new questionnaire to measure treatment outcomes for people affected by substance use disorder, including patients, clinicians, and family members.
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One-Day Accelerated TMS with D-cycloserine in adults with borderline personality disorder
This study tests whether a single day of fast-tracked TMS combined with the drug D-cycloserine can help adults with Borderline Personality Disorder who have recent suicidal thoughts.
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Adding D‑serine to TMS treatment for depression
This trial tests whether taking D‑serine along with transcranial magnetic stimulation (TMS) helps adults with major depressive disorder feel better compared with TMS plus a placebo.
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Stress responses and family history effects on depression risk in teen girls
This project will use brain scans, a smartwatch, and phone surveys to see if stress-related brain and daily-life responses predict future depression in 13–15-year-old girls, especially those with a parent who had depression.
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Ketogenic diet and nutritional interventions for first episode bipolar disorder
This study is testing if a ketogenic diet, along with regular treatment, can help people who are having their first episode of bipolar disorder or schizoaffective disorder feel better and improve their brain health.
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MitoQ treatment for early-phase schizophrenia and cognitive issues
This study is testing if MitoQ, an antioxidant, can improve thinking skills in young adults with early-phase schizophrenia who have problems with their brain's energy production.
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Understanding how exposure therapy works for OCD
This study is trying to understand how exposure therapy helps people with obsessive-compulsive disorder (OCD) by looking at different factors that affect how well the treatment works.
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Using magnetic stimulation to improve cognition in psychotic disorders
This study is testing whether a type of brain stimulation called TMS can help improve thinking skills in people with psychotic disorders like schizophrenia and bipolar disorder.
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Enhanced care for early psychosis treatment
This study is testing whether a new, more supportive treatment for people experiencing their first episode of psychosis helps them stay engaged in their care better than standard treatment.
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Using Magnesium and Vitamin B6 to Treat First Episode Bipolar Disorder
This study is testing if adding magnesium and vitamin B6 to standard treatment can help people who are having their first episode of bipolar disorder feel better and recover more effectively.
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Understanding how parents' anxiety affects their children's anxiety
This study is trying to see how parents' worries affect their kids' anxiety and whether changing how parents think about threats can help improve their children's mental health.
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Investigating the Nociceptin/Orphanin FQ receptor's role in major depression
This study looks at how a specific brain receptor might affect decision-making and stress in people with major depression to see if it can help predict future symptoms.
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Using cannabidiol to treat anxiety and depression in bipolar disorder
This study is testing if a special CBD product can help people with bipolar disorder who also struggle with anxiety and depression feel better over four weeks.
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Using magnetic stimulation to study hallucinations in schizophrenia
This study is testing if using magnetic stimulation on the brain can help reduce hallucinations in people with schizophrenia or schizoaffective disorder.
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Using a passive home sensor to find digital signs of brain energy changes from nicotinamide riboside
This project will try a contact-free home sensor to see if it can detect activity, sleep, and breathing changes related to nicotinamide riboside in people with mild cognitive impairment or mild Alzheimer's.
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Nociceptin receptor blockade to change approach and avoidance behavior in depression and anxiety.
This trial will test whether a drug that blocks the nociceptin receptor can normalize brain signals and help unmedicated adults with major depression or anxiety make more balanced approach/avoidance decisions.
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Using cognitive bias modification to improve treatment for OCD
This study is testing if a new digital program that helps change how people think can improve treatment for adults with obsessive-compulsive disorder (OCD).
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Targeted brain stimulation for contamination-based OCD
This study is testing a new brain stimulation treatment to see if it can help people with OCD who struggle with contamination and washing symptoms feel better.
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Understanding stress and control in adolescent depression
This study looks at how stress and feelings of control affect teenage girls with depression to see if it can help them cope better in everyday life.
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Investigating the link between childhood adversity and depression using brain imaging
This study looks at how tough experiences in childhood might affect the brain and lead to depression later in life, to help identify who might be at risk and how to better support them.
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Mindfulness app training for adolescents to reduce rumination
This study is testing whether using a mindfulness app can help teenagers aged 13-18 feel less anxious and depressed by reducing their tendency to overthink.
NIH-funded research (newest 40 of 117)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Neurobiological signs of resilience and recovery from substance abuse in youth who faced childhood adversity
A long-term study will explore brain patterns in young people who faced childhood adversity to understand why some stay resilient and avoid substance problems.
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APOE, fats, and immune responses in human brain cells
This project looks at how different APOE genes change the way brain cells handle fats and inflammation for people affected by Alzheimer’s, Parkinson’s, and Lewy body dementia.
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Decoding Dysmenorrhea: Longitudinal Pain Phenotypes in Adolescents and Young Adults
A study on how menstrual pain develops over time in teenagers and young adults, exploring brain and behavior to understand why some have ongoing pain.
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BDNF's role in neuron-astrocyte signaling linked to schizophrenia risk
Researchers are exploring how brain-derived neurotrophic factor (BDNF) shapes the communication between neurons and support cells to understand schizophrenia risk.
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Gut microbiome and multisensory sensitivity in teen menstrual pain
A study in adolescent girls with moderate-to-severe menstrual pain will explore how gut bacteria relate to their pain and sensitivity to different senses.
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Scalable, quick digital help for new mothers with intrusive postpartum thoughts
A brief, self-guided digital session helps new parents understand and reduce distress from unwanted postpartum thoughts.
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Trauma Recovery with Brain Signals During Written Therapy
A study at McLean Hospital will track brain activity and sleep patterns to find biomarkers that reflect how Written Exposure Therapy helps people with PTSD.
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Antibody treatment that soaks up fentanyl to prevent overdoses
A new antibody medicine that soaks up fentanyl and similar opioids is being developed to protect people at high risk of overdose.
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Comparing Medicines for a First Episode of Psychosis
A study looking at how different antipsychotic medicines work for teens and adults when they first develop psychosis, with a focus on sticking to the treatment.
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Enhanced coordinated specialty care (CSC 2.0) for first-episode psychosis
A large multi-clinic study tests a boosted version of coordinated specialty care to help people experiencing a first episode of psychosis stay in treatment and improve outcomes.
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LEAP Methods Core supports smarter care for early psychosis
A hub at a major hospital is building and maintaining a data platform and cutting-edge tools to help doctors understand and treat first-episode psychosis.
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LEAP Administrative Core supports a center focused on early psychosis research
A dedicated core at McLean Hospital helps coordinate a national network of first-episode psychosis clinics to run a big research program and a randomized trial.
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Laboratory for Early Psychosis Research (LEAP) Center for Early Intervention
A nationwide program in Massachusetts aims to improve how first-episode psychosis is treated by testing new care approaches and using data to guide decisions.
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Personalized quality-of-life tools for people with mental health and chronic conditions
Building personalized quality-of-life measures to better show how mental health and conditions like diabetes affect people's daily lives.
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Biomarkers to Guide First-Episode Schizophrenia Treatment
Researchers are testing biomarker-based methods to help doctors choose the best initial treatment for teens and young adults experiencing a first episode of psychosis.
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Insula–amygdala circuits and alcohol abuse
This project studies how binge drinking changes brain circuits between the insula and amygdala to influence alcohol seeking and anxiety in a relevant animal model.
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Longitudinal study of opioid use disorder in adults
A long-term study following 550 adults with opioid use disorder to understand how treatments and life events shape recovery over time.
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New measure to capture substance-related problems in substance use trials
Researchers are developing a new patient-centered way to quantify the negative effects of substance use to improve trials and treatments for substance use disorders.
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Synaptic teamwork between human neurons and astrocytes in brain cells from autopsy tissue
Researchers study how neurons and astrocytes work together to support healthy brain signaling using human brain cells derived from donated tissue.
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Synaptic mechanisms of a TMS protocol in depression
This NIH grant is studying how a brain-stimulation approach called cTBS works in people with depression and how drugs might boost its effects.
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How iTBS and a brain drug could boost brain wiring to help depression
A study tests whether a brain-stimulating treatment (iTBS) works by improving brain plasticity and whether adding a drug (DCS) enhances this effect for people with major depressive disorder.
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Brain changes linked to PTSD and depression after death
Using detailed molecular analyses of donated brains to learn how PTSD and depression affect specific brain regions.
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Long-term effects of teen THC exposure on the brain and motivation
This project looks at whether regular THC exposure during the teen years causes lasting changes in the brain and in motivation and thinking into adulthood.
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How Nurr1 interacts with Parkinson's risk factors and how drugs or natural molecules might control it
This project explores whether drugs and natural molecules that activate Nurr1 can help protect the dopamine-producing brain cells affected in Parkinson's disease.
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How prescription stimulants may affect overdose risk
Researchers are using adults' medical and prescription records to see whether getting stimulant medications is linked to a higher or lower chance of later overdoses.
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Personalized Parkinson's cell therapy using patient-derived stem cells
This project develops personalized therapies that use a patient's own induced pluripotent stem cells to replace lost dopamine neurons in people with Parkinson's disease.
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Foxp2 signals that shape fear learning in the brain
A scientist at a hospital is studying how a brain gene called Foxp2 affects fear learning in adult mice, with potential implications for PTSD treatments.
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Stress, brain, and body responses in teenage girls with or without a family history of depression
This project compares how stress changes the brain, body, and behavior of teenage girls who do or do not have a parent with depression.
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How MDMA boosts pleasure and social connection
Researchers are testing how MDMA and its active parts increase pleasure and social connection to help people with PTSD or depression who struggle with loss of interest.
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Biometric wearables to predict opioid relapse
A brief study will test a wearable-based tool to forecast relapse risk in adults with opioid use disorder to help prevent overdose.
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Understanding brain circuit changes behind mood and behavior problems in Alzheimer’s
Using large sets of brain scans and advanced computer analysis to find what causes depression, anxiety, agitation, and other mood or behavior symptoms in people with Alzheimer’s disease.
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Machine learning to improve exposure therapy in everyday care
This project uses machine learning on session data from adults with OCD who are receiving exposure therapy to find which therapy processes help people get better.
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Using smartphones to spot mood changes and future depression risk in teens
This project uses teens' smartphones to track daily behavior and mood-linked signals so teens at risk for depression can be noticed earlier.
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Understanding how a parent's worry influences a child's anxiety
A parent-focused study looks at how a parent’s anxious thinking might shape a child’s worry and whether this could lead to better, more personalized treatments for anxious kids.
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Brain imaging to spot active D2 dopamine receptors tied to antipsychotic-related sensitivity in schizophrenia
This project uses a new PET tracer to detect overactive D2 dopamine receptors that can underlie medication-related sensitivity in people with schizophrenia.
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Cerebellum-to-cortex circuit behind hearing voices
Researchers are checking whether a brain circuit linking the cerebellum, thalamus, and cortex causes people with schizophrenia to hear voices.
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Aging, brain energy use, and oxidative stress in schizophrenia
This work looks at whether problems with brain energy use and oxidative stress help explain faster aging, thinking decline, and worse physical health in people with schizophrenia.
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Brain lactate changes during memory tasks in early and long-term schizophrenia
This project measures how brain lactate levels change during a working memory task in people with new and long-term schizophrenia compared with people without schizophrenia.
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How parents' perceptions of threats affect their children's anxiety
This study looks at how parents' worries about uncertain situations can affect their kids' anxiety, aiming to find ways to help families manage anxiety together.
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Assessing how people respond to threats using mobile technology
This study is looking to create new ways to understand how people react to feelings of threat, which can help those dealing with anxiety and PTSD, by using mobile technology to track their emotions in real-time with a large group of 75,000 participants.
Quick answers
How many clinical trials run by Mclean Hospital are recruiting right now?
27, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 2 countries. The most sites are in United States (27 trials), Switzerland (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 1/2: 3, Phase 2: 3, Early Phase 1: 2, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.