LEAP Methods Core supports smarter care for early psychosis
Official title: LEAP Methods Core
Funded at Mclean Hospital · NIH-11419743 · Data updated 2026-11-12
A hub at a major hospital is building and maintaining a data platform and cutting-edge tools to help doctors understand and treat first-episode psychosis.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mclean Hospital NIH-funded |
| Lab location | 1 site (Belmont, United States) |
| Project start | May 15, 2019 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $404,379 |
| NIH project number | 5P50MH115846-08 |
| Project ID | NIH-11419743 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals experiencing a first psychotic episode and whose care is documented in the LEAP Center databases.
✕Less likely to help
Patients not linked to the LEAP data platforms or not involved in data-driven phenotyping and prediction efforts may not directly benefit.
What this research studies
This grant supports a central data and methods core that collects and harmonizes diverse clinical information from people with first-episode psychosis. It will provide advanced machine learning and causal inference tools to help researchers predict outcomes and compare treatments using large, linked databases including clinical records, trials, and insurance data. The core will ensure secure storage and access to high-dimensional data so investigators can analyze patterns across care settings. This work is designed to enable researchers at LEAP to generate actionable insights for improving care pathways and outcomes for patients experiencing their first psychotic episode.
Why it matters
Potential benefit: If successful, patients with first-episode psychosis could benefit from faster, more accurate prediction of outcomes and more effective, personalized treatment strategies.
How similar studies have gone: Previous efforts show that large, integrated clinical databases with advanced analytics can improve understanding of complex mental health conditions, though this approach remains an area of active research.
Where this research is happening
-
Mclean Hospital
Belmont, United States Active
Researchers
- Principal investigator: Hernan, Miguel — Mclean Hospital
- Study coordinator: Hernan, Miguel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.