Longitudinal study of opioid use disorder in adults
Official title: Longitudinal Cohort Study of Opioid Use Disorder
Funded at Mclean Hospital · NIH-11384057 · Data updated 2026-11-12
A long-term study following 550 adults with opioid use disorder to understand how treatments and life events shape recovery over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mclean Hospital NIH-funded |
| Lab location | 1 site (Belmont, United States) |
| Project start | June 1, 2026 |
| Project end | March 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $736,811 |
| NIH project number | 1R01DA066062-01 |
| Project ID | NIH-11384057 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 years and older with diagnosed opioid use disorder who are willing to participate in monthly remote surveys and annual interviews.
✕Less likely to help
Individuals not engaged in ongoing-treatment programs or those unwilling to participate in remote assessments may not benefit.
What this research studies
This project follows adults with opioid use disorder for several years, using monthly remote surveys and yearly interviews to track recovery, treatment experiences, and life context. Participants will provide information from home, allowing researchers to capture detailed, timely data on how treatments like buprenorphine and other factors influence outcomes. The study builds on prior work showing high engagement with monthly assessments and aims to fill gaps about long-term trajectories and real-world effectiveness. Data will come from multiple sites across the United States, reflecting diverse communities and treatment settings.
Why it matters
Potential benefit: Results could inform more effective, patient-centered long-term care plans for opioid use disorder.
How similar studies have gone: Prior longitudinal studies had limitations but demonstrated feasibility with regular follow-up and detailed outcome tracking.
Where this research is happening
-
Mclean Hospital
Belmont, United States Active
Researchers
- Principal investigator: Mchugh, Rebecca Kathryn — Mclean Hospital
- Study coordinator: Mchugh, Rebecca Kathryn
Related research
Other NIH-funded projects on the same topics.
-
Systems analysis to improve opioid use disorder care after jail release (SAIA-MOUD)
A program to help people with opioid use disorder get better, faster, and safer care after they leave jail.
-
Precise epigenetic drugs for opioid addiction
A tiny, targeted drug approach is being developed to help people with opioid use disorder by rewriting the epigenetic signals in the brain to reduce cravings and relapse risk.
-
Increasing Access to Medications for Opioid Use Disorder for Unhoused Montanans
This project helps unhoused people in Montana get life-saving medicines for opioid use disorder through clinics connected to syringe service programs, a nurse-led MOUD model, and peer support.
-
Optimizing long-acting PrEP and opioid treatment for people in jails and prisons
This project tests a real-world approach to using long-acting PrEP and buprenorphine for HIV prevention and opioid treatment among incarcerated individuals and after release.
-
Scaling up medications for opioid use disorder in residential treatment programs
This grant studies how to help residential treatment programs provide medications for opioid use disorder to reduce overdoses after discharge, focusing on real-world settings and policies.
-
Increasing Capacity at a Native Community Clinic to Improve Opioid Care for urban AI/AN
This grant helps a Native American health clinic build its research capacity to better serve urban American Indian and Alaska Native people dealing with opioid use disorder and related health issues.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.