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Clinical trials and research at Karolinska University Hospital

• 44Clinical trials
• 18Countries

Newest trials

All recruiting trials (44)

• Myocardial Perfusion and Tissue Characterization with Photon-Counting CT in TAVI Patients

  This study tests whether photon-counting CT can measure heart blood flow and tissue properties as well as MRI in patients planning a TAVI procedure.

  Recruiting Karolinska University Hospital · Huddinge, Stockholm County · NCT07799363

• HBOT for late radiation tissue injury: who benefits and when

  This study follows adults with late radiation injury of the bladder or bowel who were treated with hyperbaric oxygen therapy to see who benefits most and when to start treatment.

  Recruiting Karolinska University Hospital · Stockholm · NCT07611864

• Immune therapy with rituximab to restore ovarian function and fertility in autoimmune premature ovarian insufficiency

  This trial will test whether the immune drug rituximab can restore ovarian function and improve fertility for women with autoimmune premature ovarian insufficiency.

  Recruiting at 2 sites Phase 3 Karolinska University Hospital · Stockholm and 1 other locations · NCT07509840

• Catheter ablation vs optimized medical care for very elderly with atrial fibrillation

  In people aged 78 and up with AF, this study tests whether catheter ablation can help by comparing it to tailored medical therapy, using a wearable rhythm monitor to track AF over time.

  Recruiting Karolinska University Hospital · Linköping and 1 other locations · NCT07424690

• Fatigue and thinking problems after allogeneic stem cell transplant (synapse damage or brain GVHD)

  This project uses PET scans and spinal fluid samples to try to find why people who had an allogeneic stem cell transplant have persistent fatigue and thinking problems.

  Recruiting Karolinska University Hospital · Stockholm · NCT07365696

• Intraperitoneal paclitaxel added to standard systemic chemotherapy for gastric cancer with peritoneal metastases

  This trial tests whether giving paclitaxel directly into the abdomen together with standard systemic chemotherapy helps people with gastric cancer that has spread to the peritoneum live longer than systemic chemotherapy alone.

  Recruiting at 2 sites Phase 3 Karolinska University Hospital · Verona and 6 other locations · NCT07304271

• Waiting on Atrial Fibrillation Intervention Therapy: Weight loss before ablation

  This trial tests whether adding weekly semaglutide before first-time AF ablation helps people who are overweight or obese have better rhythm outcomes.

  Recruiting Phase 4 Karolinska University Hospital · Stockholm · NCT07275697

• Endogenous energy production in critically ill patients

  This study tests when critically ill, mechanically ventilated patients start responding normally to feeding by measuring how their own glucose, fat, and protein production changes over time.

  Recruiting Karolinska University Hospital · Stockholm · NCT07059988

• Comparing methods to lower heart rate for cardiac imaging

  This study is testing different ways to lower heart rate before heart imaging to see which method works best for patients.

  Recruiting Karolinska University Hospital · Stockholm, Huddinge · NCT06879769

• Amino acid supplementation for patients undergoing kidney dialysis

  This study tests if giving extra amino acids to patients on kidney dialysis can improve their health while they are in the ICU.

  Recruiting Karolinska University Hospital · Stockholm · NCT06835816

• Using HER2-PET imaging to guide HER2-ADC treatment in metastatic HER2-expressing breast cancer

  This trial will test whether HER2-targeted PET imaging can help find people with metastatic HER2-expressing breast cancer who should get the HER2-directed antibody‑drug conjugate T‑DXd.

  Recruiting Karolinska University Hospital · Solna · NCT06830382

• Neoadjuvant nivolumab alone versus nivolumab plus ipilimumab for resectable stage III melanoma

  This trial will try two pre-surgery immunotherapy approaches—nivolumab alone or nivolumab plus ipilimumab—in adults with resectable stage III melanoma to see which gives better tumor response and longer benefit.

  Recruiting at 3 sites Phase 3 Karolinska University Hospital · Gothenburg and 2 other locations · NCT06794775

• First human use of 177Lu‑AKIR001 for CD44v6‑positive advanced cancers

  This trial tests a Lutetium‑177 radiolabeled drug (AKIR001) in adults with advanced, irresectable CD44v6‑expressing solid tumors who have no reasonable systemic treatment options.

  Recruiting Early Phase 1 Karolinska University Hospital · Stockholm, Stockholm County · NCT06639191

• Contact radiotherapy for rectal cancer treatment

  This study is testing a new treatment for early rectal cancer that combines a type of radiation therapy with a shorter course of treatment to see if it can help preserve organs and cause fewer side effects than standard options.

  Recruiting at 2 sites Karolinska University Hospital · Stockholm, Solna and 1 other locations · NCT06501053

• Understanding genetic influences and biomarkers in heart failure management

  This study is trying to find new biological markers in heart failure patients to see if they can help doctors better understand who will respond to treatments and who won't.

  Recruiting Karolinska University Hospital · Stockholm · NCT06435585

• Evaluating frailty and quality of life in women with ovarian cancer undergoing surgery

  This study is testing how frailty affects survival and quality of life in women with advanced ovarian cancer who are having surgery, while also looking at different ways to measure frailty and the safety of certain surgical procedures.

  Recruiting at 4 sites Karolinska University Hospital · Stockholm, Solna and 3 other locations · NCT06298877

• Comparing treatments for small kidney tumors

  This study is testing whether a new way to destroy small kidney tumors works better and is safer than traditional surgery for people with localized kidney cancer.

  Recruiting Karolinska University Hospital · Stockholm · NCT06278506

• Robotic surgery for gallbladder cancer treatment

  This study is testing whether robotic surgery for gallbladder cancer helps patients recover faster and have fewer complications compared to traditional open surgery.

  Recruiting Karolinska University Hospital · Stockholm · NCT06246448

• Evaluating Bulevirtide Treatment for Chronic Hepatitis D

  This study is testing if a new treatment called Bulevirtide can help people with Chronic Hepatitis D feel better and improve their quality of life.

  Recruiting Karolinska University Hospital · Stockholm · NCT06051045

• Using diaphragm ultrasound to predict respiratory complications after surgery

  This study is testing if using ultrasound to check diaphragm function can help predict breathing problems after major surgeries.

  Recruiting at 2 sites Karolinska University Hospital · Stockholm, Stockholm County and 1 other locations · NCT05906030

• Comparing trastuzumab deruxtecan to standard treatment for HER2-positive breast cancer

  This study is testing if a new drug called trastuzumab deruxtecan can work better than standard treatment for people with early-stage HER2-positive breast cancer before surgery.

  Recruiting Phase 2 Karolinska University Hospital · Malmö and 6 other locations · NCT05900206

• Using personalized MRD to guide treatment after stem cell transplant for MDS patients

  This study is testing if giving personalized treatments like Azacitidine or donor lymphocytes can help prevent relapse in people with myelodysplastic syndromes after they’ve had a stem cell transplant.

  Recruiting Phase 2 Karolinska University Hospital · Stockholm · NCT05788679

• Comparing quality of life after different types of aortic aneurysm repair

  This study looks at how different types of surgery for abdominal aortic aneurysms affect the quality of life for patients over three years.

  Recruiting Karolinska University Hospital · Stockholm · NCT05774938

• Combining Alectinib with Radiation Therapy for Advanced Lung Cancer with ALK Mutation

  This study is testing if combining alectinib with targeted radiation therapy can help people with advanced lung cancer that has an ALK mutation feel better and live longer.

  Recruiting Karolinska University Hospital · Stockholm · NCT05724004

• Hormonal treatment effects on transgender men

  This study tests if giving testosterone to transgender men for six weeks can help improve their feelings about their gender and boost their mental health compared to a placebo.

  Recruiting Karolinska University Hospital · Stockholm · NCT05649605

• Comparing Micronized Progesterone and Norethisterone Acetate for Menopausal Hormone Therapy

  This study is testing whether micronized progesterone or norethisterone acetate works better and is safer for treating menopausal symptoms in postmenopausal women.

  Recruiting Phase 3 Karolinska University Hospital · Stockholm · NCT05586724

• Studying lactate levels in patients with septic shock

  This study is testing how lactate levels change in adults with septic shock in the ICU to see if it can help us understand their condition better and improve their care.

  Recruiting Karolinska University Hospital · Stockholm, Stockholm County · NCT05349370

• Using GnRHa to protect fertility during chemotherapy for young women

  This study is testing if a hormone treatment can help young women keep their ability to have children while they undergo chemotherapy for cancer.

  Recruiting at 4 sites Phase 3 Karolinska University Hospital · Gothenburg and 16 other locations · NCT05328258

• Imaging solid tumors using a new tracer called 68Ga-FAPI

  This study is testing a new imaging method using a special tracer to see if it can help doctors better detect certain types of cancer in patients who are having surgery.

  Recruiting Phase 1 Karolinska University Hospital · Stockholm · NCT05172310

• Home-based exercise guidance for patients with liver cirrhosis

  This study is testing whether giving liver cirrhosis patients a structured exercise plan or just verbal advice helps them be more active after leaving the hospital.

  Recruiting Karolinska University Hospital · Stockholm · NCT05061576

• Using mesalamine to prevent colorectal cancer in Lynch Syndrome patients

  This study is testing if taking mesalamine can help prevent colorectal cancer in people with Lynch Syndrome.

  Recruiting at 5 sites Phase 2 Karolinska University Hospital · Aalborg and 7 other locations · NCT04920149

• 177Lu-DOTATATE treatment for children with high-risk neuroblastoma

  This study is testing a new treatment called 177Lu-DOTATATE to see if it can help children with high-risk neuroblastoma that has come back or worsened.

  Recruiting at 9 sites Phase 2 Karolinska University Hospital · Copenhagen, Copenhagen and 8 other locations · NCT04903899

• Using Lugol's solution before thyroid surgery for hyperthyroidism

  This study is testing if taking Lugol's solution before thyroid surgery can help reduce complications for people with hyperthyroidism.

  Recruiting Phase 3 Karolinska University Hospital · Solna, Stockholm County · NCT04856488

• Comparing two treatments for relapsing prostate cancer

  This study is testing whether a new imaging-guided treatment or standard salvage radiotherapy works better for men with prostate cancer that has come back after surgery.

  Recruiting at 2 sites Phase 3 Karolinska University Hospital · Gothenburg, Göteborg and 4 other locations · NCT04794777

• Precision radiation for melanoma patients resistant to immune therapy

  This study is testing whether a specific type of radiation therapy can help melanoma patients who aren't responding to their current immune treatment feel better and improve their overall health.

  Recruiting Karolinska University Hospital · Stockholm · NCT04793737

• Intermittent dosing of ibrutinib for advanced chronic lymphocytic leukemia

  This study is testing if taking the cancer drug ibrutinib in a 'ON-OFF' way can help people with advanced chronic lymphocytic leukemia stay healthy while possibly having fewer side effects and lower costs.

  Recruiting at 6 sites Phase 1/2 Karolinska University Hospital · Trondheim and 8 other locations · NCT04771507

• Comparing proton and photon radiation therapy for high-risk rectal cancer

  This study is testing if proton beam radiation therapy can be better than traditional photon therapy for people with high-risk rectal cancer by seeing if it causes less stomach upset during treatment.

  Recruiting at 9 sites Karolinska University Hospital · Stockholm, Solna and 8 other locations · NCT04525989

• Comparing two treatment approaches for esophageal cancer

  This study is testing two different treatment plans for people with advanced esophageal cancer to see which one helps them live longer and feel better after a year.

  Recruiting at 12 sites Phase 3 Karolinska University Hospital · Montreal, Quebec and 11 other locations · NCT04460352

• Treatment for Acute Lymphoblastic Leukaemia in Young Patients

  This study is testing a new way to treat young patients with acute lymphoblastic leukaemia to see if it can improve their chances of survival while reducing side effects.

  Recruiting at 120 sites Phase 3 Karolinska University Hospital · Brussels and 136 other locations · NCT04307576

• Evaluating care for patients with popliteal artery aneurysm

  This study is trying to see how different types of care before and after surgery can affect the health and quality of life for people with popliteal artery aneurysms.

  Recruiting at 2 sites Karolinska University Hospital · Gothenburg and 1 other locations · NCT04188808

• Treatment protocol for young patients with acute lymphoblastic leukemia

  This study is trying to find the best ways to treat young patients with acute lymphoblastic leukemia by learning from successful treatments to improve their care and survival rates.

  Recruiting at 11 sites Karolinska University Hospital · Aalborg and 56 other locations · NCT03911128

• Timing of kidney treatment in critically ill patients

  This study is trying to find out if starting kidney treatment earlier can help critically ill patients with kidney injury feel better and have better outcomes.

  Recruiting Karolinska University Hospital · Stockholm · NCT03629977

• Comparing methods for closing loop ileostomies after rectal cancer surgery

  This study is testing whether using a stapled method or a hand-sewn method to close loop ileostomies after rectal cancer surgery leads to fewer complications, like blockages or hernias.

  Recruiting at 11 sites Karolinska University Hospital · Gothenburg and 10 other locations · NCT02669992

• Comparing surgery and radiotherapy for advanced prostate cancer

  This study is testing if surgery combined with radiation can help men with advanced prostate cancer live longer compared to just using radiation and hormone therapy.

  Recruiting at 29 sites Karolinska University Hospital · Aalborg and 29 other locations · NCT02102477

Quick answers

How many clinical trials run by Karolinska University Hospital are recruiting right now?

44, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 18 countries. The most sites are in Sweden (44 trials), Norway (6 trials), Denmark (5 trials), Finland (3 trials), Lithuania (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 9, Phase 2: 4, Early Phase 1: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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