Understanding genetic influences and biomarkers in heart failure management
Official title: Responders and Non-responders in the Management of Heart Failure - Significance of Genetic Influence and Identification of Novel Informative Biomarkers
Run by Karolinska University Hospital · NCT06435585 · Data updated 2026-11-12
This study is trying to find new biological markers in heart failure patients to see if they can help doctors better understand who will respond to treatments and who won't.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 5000 (estimated) |
| Sponsor | Karolinska University Hospital Academic / other |
| Locations | 1 site (Stockholm) |
| Status | Recruiting |
| Started | February 17, 2021 |
| Main results expected | December 31, 2030 |
| Study ends | December 31, 2030 |
| Registry record updated | August 10, 2026 |
| Trial ID | NCT06435585 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals diagnosed with heart failure who have provided informed consent and are registered in the SwedeHF registry.
✕Probably not a fit
Patients who have recently donated plasma or blood, or those with conditions that may affect their participation or the study's results, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study utilizes the SwedeHF registry, the largest heart failure registry globally, to collect and analyze biological samples from heart failure patients across Sweden. The study aims to create a high-quality biobank linked to the registry, which will include blood plasma, whole blood, and urine samples for genetic, proteomic, and metabolomic analyses. By examining these samples, researchers hope to identify novel biomarkers that can help differentiate between responders and non-responders to heart failure treatments. This initiative will enhance future research opportunities within the national heart failure registry.
Why it matters
Potential benefit: If successful, this study could lead to improved personalized treatment strategies for heart failure patients based on genetic and biomarker profiles.
How similar studies have gone: Other studies utilizing biobanks and registries for heart failure research have shown promise, indicating that this approach is both relevant and potentially impactful.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Written informed consent 2. Heart failure defined by symptoms and signs of heart failure as judged by the local investigator 3. Registered in SwedeHF Exclusion Criteria: 1. Plasma donation within 1 month of enrolment or any blood donation/blood loss \>500 mL during the 3 months prior to enrolment 2. Previous allogeneic bone marrow transplant (genetics) 3. In the opinion of the investigator, condition/s that may either put the patient at risk on participation or influence the results or the patient's ability to participate in the study.
Where it's running
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Karolinska University hospital
Stockholm, Sweden Recruiting
Study contacts
- Study coordinator: Camilla Hage, Ass prof
- Email: camilla.hage@regionstockholm.se
- Phone: +46 (0)703340660
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Other studies for the same condition or treatment. Recruiting studies are listed first.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.