Comparing methods to lower heart rate for cardiac imaging
Official title: Optimization of Patient Preparation and Imaging Techniques for Cardiac CT
Run by Karolinska University Hospital · NCT06879769 · Data updated 2026-11-12
This study is testing different ways to lower heart rate before heart imaging to see which method works best for patients.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 240 (estimated) |
| Sponsor | Karolinska University Hospital Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Stockholm, Huddinge) |
| Status | Recruiting |
| Started | January 1, 2021 |
| Main results expected | January 1, 2026 |
| Study ends | December 1, 2027 |
| Registry record updated | March 17, 2025 |
| Trial ID | NCT06879769 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 years or older who have a referral for a cardiac CT examination.
✕Probably not a fit
Patients with atrial fibrillation, pacemakers, or contraindications to beta-blockers may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to evaluate four different methods for reducing heart rate prior to coronary computed tomography angiography (CCTA) imaging. The study will compare the effectiveness of oral versus intravenous administration of beta-blockers, as well as the impact of a music intervention on patient experience. A total of 240 participants will be randomized into four groups, with heart rate monitored using a cardiac output meter and sensory experiences assessed through visual analog scales. The study also seeks to determine the optimal timing for imaging after contrast administration to minimize motion artifacts and enhance image quality.
Why it matters
Potential benefit: If successful, this study could lead to improved cardiac imaging techniques that reduce radiation exposure and enhance diagnostic accuracy for patients.
How similar studies have gone: Other studies have shown success with beta-blocker administration for heart rate control in imaging, but this specific comparison of methods is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participant with a preexisting referral for a Cardiac CT examination * Age 18 years or older Exclusion Criteria: * Age under 18 years * Atrial fibrillation * Pacemaker * Participation in clinical drug trials * Contraindications to beta-blockers * Severe medical conditions * Challenges in comprehending study information * Pregnancy
Where it's running
-
ME Radiologi Huddinge, Karolinska University Hospital
Stockholm, Huddinge, Sweden Recruiting
Study contacts
- Principal investigator: Anders Svensson-Marcial, PhD — Karolinska University Hospital, Department of Clinical Science, Intervention and Technology
- Study coordinator: Aziza Adem Adem, MSc
- Email: aziza.adem@ki.se
- Phone: +46 8 123 865 37
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.