Sponsor or institution
Clinical trials and research at Joslin Diabetes Center
As of November 12, 2026, Find a Trial lists 7 clinical trials run by Joslin Diabetes Center that are recruiting, at sites in 2 countries (most in United States (7), Canada (1)). By phase: Phase 3 (1), Phase 4 (1). There are also 62 NIH-funded research projects at this institution, with $41.0 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 7Clinical trials
- 62NIH research projects
- 2Countries
Newest trials
All recruiting trials (7)
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Understanding glucagon and sugar metabolism after meals in people with and without PBH after weight-loss surgery
This study tests how glucagon and post-meal glucose handling differ between people who have post-bariatric surgery hypoglycemia and those who don’t.
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Diabetes Body Project 2: a body-image program for women with type 2 diabetes
This program will test whether a short body-image prevention program helps women aged 18–40 with type 2 diabetes feel better about their bodies, reduce disordered eating behaviors, and improve blood sugar control.
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Exercise after pregnancy to activate infant brown fat
This study will test if a mother's exercise during pregnancy and after birth changes her breast milk so it increases her infant's brown fat activity and energy use.
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High-protein diabetes formula to protect muscle in people with Type 2 diabetes starting incretin medications
This study will test whether a high-protein diabetes-specific formula helps preserve or increase lean muscle in overweight or obese adults with type 2 diabetes who are starting GLP‑1 or dual GLP‑1/GIP incretin medications.
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In-ear blood flow monitoring for people with low blood sugar after weight-loss surgery
This pilot will try a small in-ear wearable that measures head blood flow in adults with post-bariatric hypoglycemia and compare results to surgical and non-surgical control groups.
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High-intensity interval exercise to support brain activity and weight maintenance
This trial will test whether a 12-week high-intensity interval training (HIIT) program changes brain activity and helps with weight maintenance in adults 18–70, including people who regained weight after bariatric surgery.
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Using Sotagliflozin to Slow Kidney Decline in Type 1 Diabetes Patients
This study is testing if sotagliflozin can help slow down kidney problems in people with type 1 diabetes and kidney disease.
NIH-funded research (newest 40 of 62)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Brown-fat lipids and their mimics for better metabolism
Researchers are studying small fat-related molecules produced by brown fat to understand how they help with metabolism and may lead to new ways to treat type 2 diabetes.
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Understanding cognitive decline and Alzheimer’s changes in people with long‑duration type 1 diabetes
A long-term study in adults with type 1 diabetes investigates why some people experience memory and thinking difficulties and brain changes typical of Alzheimer's disease.
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Epitranscriptomics in obesity and type 2 diabetes
Researchers are studying how gene activity changes in fat tissue and other organs to better understand obesity and type 2 diabetes, with the goal of finding new ideas for treatment.
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APOL1-Linked Kidney Transplant Outcomes Network (APOLLO) Clinical Center
This grant supports a clinical center that follows kidney transplant patients to understand how APOL1 genetics affect transplant results and living donor health.
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Proteostasis and lipid balance in aging: SKN-1A/Nrf1 in humans
A study in a worm model explores how a human-linked protein (Nrf1) helps balance fat, protein maintenance, and aging, with potential implications for related human diseases.
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Glucagon Pump Therapy for PBH in People After Bariatric Surgery
A new approach uses a patch pump and smart control to deliver glucagon during meal-related lows in adults who had bariatric surgery and developed dangerous hypoglycemia.
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Identifying Neurocognitive Risks in Kids with Type 1 Diabetes
A multi-center study will follow prepubertal children with newly diagnosed Type 1 diabetes and similar peers without diabetes to understand what affects their thinking and memory over time.
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Understanding what raises heart disease risk in people with well-controlled type 1 diabetes
Researchers are studying why some people with type 1 diabetes still develop heart disease even when traditional risk factors are controlled.
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Modulating immune response to improve in-body gene editing for muscular dystrophy
A study tests a gene-editing approach delivered by a virus to repair the dystrophin gene in muscle, aiming to help people with Duchenne muscular dystrophy.
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Translating beta-cell messages to prevent diabetes trouble
A beta-cell focused study at Joslin Diabetes Center will look at how glucose affects the production of insulin at the level of mRNA translation and how this process might go awry in diabetes.
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How genes and microRNAs shape body fat
This project looks at how genes and tiny RNAs in fat cells influence obesity and type 2 diabetes risk for adults with metabolic concerns.
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Targeting aging in insulin-producing pancreatic beta cells
This project looks at whether removing or blocking harmful signals from aged insulin-making cells can help people with type 2 diabetes keep their blood sugar under control.
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Stopping fat-driven cell damage to protect metabolic health
Testing whether removing certain tiny RNAs inside cells can prevent fat-related liver and metabolic damage in adults with type 2 diabetes.
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Mom's exercise during breastfeeding to boost baby metabolism
This project tests whether moms' exercise while breastfeeding changes breast milk in ways that help babies burn more fat and have healthier body composition.
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How heat‑producing (thermogenic) fat cells are controlled
This project looks at the molecular switches that turn on calorie‑burning fat cells to help people with obesity and related metabolic problems.
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Gut-friendly bacteria from exercise that boost metabolism
This grant explores whether bacteria in the gut that use muscle lactate can boost healthy metabolism and exercise benefits when paired with regular exercise.
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How the insulin receptor controls cell signals and blood sugar
Researchers are looking at how the insulin receptor and its signaling pathways work in cells and people with type 2 diabetes to help find better ways to treat insulin resistance.
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Understanding youth-onset type 2 diabetes: predicting, preventing, and personalizing care
A study at a major diabetes center is looking at why some youths develop type 2 diabetes during puberty and how to prevent it or keep it from getting worse, so future kids at risk can stay healthier.
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Maternal exercise and children's blood sugar regulation
This project is seeing whether mothers exercising before and during pregnancy can help prevent type 2 diabetes and improve blood sugar control in their children.
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How exercise changes under-the-skin fat to help blood sugar control
This research looks at how exercise-related changes in the fat beneath the skin can improve blood sugar control for people with adult-onset (type 2) diabetes and related metabolic conditions.
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Early heart changes linked to worsening kidney function in type 1 diabetes
This project will look at whether people with type 1 diabetes who are losing kidney function have early changes in heart muscle compared with people with stable kidney function and people without diabetes.
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How insulin and IGF‑1 signals help pancreatic beta cells survive and grow
Researchers are looking at whether insulin and IGF‑1 signaling keeps insulin-producing beta cells alive and able to multiply for people with type 1 and type 2 diabetes.
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Understanding Heart Disease Risks in People with Well-Controlled Type 1 Diabetes
This project looks at why people with Type 1 diabetes might still get heart disease, even when their other health factors are well-managed.
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Understanding calorie-burning brown and beige fat
This project looks at how calorie-burning fat in adults works and how it might help people with type 2 diabetes.
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Understanding and preventing brain changes in children with type 1 diabetes
This project looks at how type 1 diabetes affects brain health in young children and aims to find ways to protect their developing brains.
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How beta-cells respond to high glucose levels and their role in diabetes
This study looks at how insulin-producing cells in the body react to high sugar levels and aims to understand why they sometimes don't work properly, which can lead to diabetes, in hopes of finding new ways to help keep these cells healthy and improve diabetes treatments.
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A Glucagon Pump for Low Blood Sugar After Weight Loss Surgery
This project is developing a special pump that delivers glucagon to help people who experience dangerously low blood sugar after bariatric surgery.
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How digestive-pancreas cells affect insulin-producing beta cells
Researchers are looking at whether molecules released by pancreatic acinar and duct cells change how insulin-producing beta cells work in people with or at risk for type 1 diabetes.
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Understanding Kidney Transplant Outcomes for People with APOL1 Gene Variations
This project looks at how a specific gene, APOL1, affects the success of kidney transplants, particularly for African Americans, to help improve long-term outcomes for patients.
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Understanding How Insulin Works in Diabetes and Insulin Resistance
This project aims to understand how insulin and similar hormones send messages inside our cells and what goes wrong in people with diabetes and insulin resistance.
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RNA chemical changes linked to obesity and type 2 diabetes
Researchers will map chemical tags on RNA from people with obesity and type 2 diabetes to better understand signals that control metabolism.
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Improving Gene Editing for Duchenne Muscular Dystrophy
This work explores how to make gene editing more effective for Duchenne muscular dystrophy by managing the body's natural defenses.
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Understanding how a key protein helps cells stay healthy
This project explores how a protein, similar to one in humans, helps cells manage fats and proteins, which could offer new ways to think about aging and certain genetic conditions.
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Investigating how certain proteins affect kidney function decline in diabetes
This study is looking at how diabetes affects kidney function, especially in people with serious kidney problems, to find specific proteins that might help explain the decline and lead to better treatments for kidney disease.
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Understanding how lipotoxicity affects metabolic health and diabetes complications
This study is looking at how tiny molecules called snoRNAs might help protect against damage from fatty foods, which can lead to problems like fatty liver disease in people with type 2 diabetes, using mice to see what happens when these snoRNAs are missing.
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Understanding how aging affects insulin-producing cells in diabetes
This study looks at how getting older affects the cells in your pancreas that make insulin, especially for people with type 2 diabetes, and it hopes to find ways to help these cells work better again.
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Investigating cardiovascular disease risks in people with well-controlled type 1 diabetes
This study is looking into why people with well-managed type 1 diabetes still have a higher chance of heart problems, by comparing their heart and blood samples with those from people with type 2 diabetes and those without diabetes, to find out what makes their risks different.
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Understanding how fat cells regulate heat production
This study is looking at how special fat cells help keep our body warm and burn energy, and it aims to find new ways to treat obesity and related health issues by understanding the genes that control these fat cells.
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How gut bacteria help improve exercise and metabolism through lactate
This study is looking at how certain gut bacteria can help turn lactate from exercise into helpful substances that might improve your workout performance and overall health, especially if you have trouble with blood sugar levels. By adding these special bacteria during exercise, the researchers hope to see if it can le
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Improving the use of diabetes devices for young adults with type 1 diabetes
This study is all about helping young adults with type 1 diabetes feel more comfortable using tools like glucose monitors and insulin pumps, by understanding how their personal feelings and social views affect their use of these devices, and creating a supportive program that meets their needs.
Quick answers
How many clinical trials run by Joslin Diabetes Center are recruiting right now?
7, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 2 countries. The most sites are in United States (7 trials), Canada (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 3: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.