Investigating how certain proteins affect kidney function decline in diabetes
Official title: Causal connections between axon guidance proteins and early progressive kidney function decline in diabetes
Funded at Joslin Diabetes Center · NIH-11105789 · Data updated 2026-11-12
This study is looking at how diabetes affects kidney function, especially in people with serious kidney problems, to find specific proteins that might help explain the decline and lead to better treatments for kidney disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Joslin Diabetes Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 1, 2022 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $611,231 |
| NIH project number | 5R01DK131061-04 |
| Project ID | NIH-11105789 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with diabetes who are experiencing advanced kidney disease and have significant protein in their urine.
✕Less likely to help
Patients without diabetes or those with early-stage kidney disease may not benefit from this research.
What this research studies
This research focuses on understanding the mechanisms behind the decline in kidney function in patients with diabetes, particularly those with advanced kidney disease. By studying diabetic patients with significant kidney damage, the researchers aim to identify specific proteins that may contribute to this decline. They will analyze blood samples to find patterns in circulating proteins and microRNAs that are linked to kidney damage. The goal is to uncover new insights that could lead to better treatments and prevention strategies for kidney disease in diabetes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow or prevent kidney function decline in diabetic patients.
How similar studies have gone: Previous research has shown promising results in understanding kidney disease mechanisms, but this specific approach focusing on axon guidance proteins is novel.
Where this research is happening
-
Joslin Diabetes Center
Boston, United States Active
Researchers
- Principal investigator: Krolewski, Andrzej S — Joslin Diabetes Center
- Study coordinator: Krolewski, Andrzej S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.