Understanding Heart Disease Risks in People with Well-Controlled Type 1 Diabetes
Characterization of risk factors for excessive cardiovascular diseases (CVD) from circulating and cardiovascular tissues of people with well-controlled chronic type 1 diabetes
This project looks at why people with Type 1 diabetes might still get heart disease, even when their other health factors are well-managed.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Joslin Diabetes Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11194457 on NIH RePORTER |
What this research studies
People with Type 1 diabetes (T1D) often face a higher risk of heart disease, even when their blood pressure, cholesterol, and blood sugar are well-controlled. This research aims to uncover the specific reasons behind this accelerated risk by examining heart and blood vessel tissues, as well as blood samples, from individuals with T1D. Researchers are looking for unique markers like advanced glycation end-products (AGEs), inflammatory signals, and specific autoantibodies that might contribute to heart problems. The goal is to identify new pathways that lead to heart disease in T1D, beyond what we currently understand.
Who could benefit from this research
Good fit: This research is relevant to people with Type 1 diabetes, especially those who have lived with the condition for a long time and are concerned about heart disease.
Not a fit: Patients without Type 1 diabetes or those not at risk for cardiovascular complications may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to predict, prevent, or treat heart disease specifically for people living with Type 1 diabetes.
How similar studies have performed: Previous studies have shown that people with long-term Type 1 diabetes can have accelerated hardening of the arteries despite good diabetes management, suggesting this approach builds on existing observations.
Where this research is happening
Boston, United States
- Joslin Diabetes Center — Boston, United States (Active)
Researchers
- Principal investigator: King, George L — Joslin Diabetes Center
- Study coordinator: King, George L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.