Epitranscriptomics in obesity and type 2 diabetes
Official title: Epitranscriptomics in human obesity and type 2 diabetes
Funded at Joslin Diabetes Center · NIH-11398955 · Data updated 2026-11-12
Researchers are studying how gene activity changes in fat tissue and other organs to better understand obesity and type 2 diabetes, with the goal of finding new ideas for treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Joslin Diabetes Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $1,968,589 |
| NIH project number | 5RC2DK139552-03 |
| Project ID | NIH-11398955 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with obesity and/or type 2 diabetes who may contribute relevant tissue samples or clinical data.
✕Less likely to help
Individuals without obesity or type 2 diabetes or without access to participating clinics may not directly benefit.
What this research studies
This project seeks to map how RNA modifications and related regulatory RNAs affect metabolism in people with obesity and type 2 diabetes. Using patient data and advanced sequencing, the team will build a comprehensive view of how gene expression is controlled across tissues such as adipose tissue, liver, and pancreas. The aim is to identify new targets for therapies that could improve metabolic function and diabetes control.
Why it matters
Potential benefit: If successful, this work could reveal new ways to treat obesity-related diabetes by targeting RNA-level regulatory pathways.
How similar studies have gone: Previous research hints that RNA and chromatin regulation play roles in metabolic diseases; this project builds on those findings with human tissue data.
Where this research is happening
-
Joslin Diabetes Center
Boston, United States Active
Researchers
- Principal investigator: Kulkarni, Rohit N. — Joslin Diabetes Center
- Study coordinator: Kulkarni, Rohit N.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.