Investigating cardiovascular disease risks in people with well-controlled type 1 diabetes
Characterization of risk factors for excessive cardiovascular diseases (CVD) from circulating and cardiovascular tissues of people with well-controlled chronic type 1 diabetes
This study is looking into why people with well-managed type 1 diabetes still have a higher chance of heart problems, by comparing their heart and blood samples with those from people with type 2 diabetes and those without diabetes, to find out what makes their risks different.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Joslin Diabetes Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11074281 on NIH RePORTER |
What this research studies
This research focuses on understanding why individuals with well-managed type 1 diabetes (T1D) still face high risks of cardiovascular diseases (CVD). It examines cardiovascular tissues and blood samples from people with T1D, type 2 diabetes, and non-diabetic individuals to identify unique risk factors. The study utilizes advanced techniques like single-cell sequencing and plasma metabolomics to analyze the differences in immune responses and metabolic pathways related to CVD. By comparing these groups, the research aims to uncover the underlying mechanisms that contribute to increased CVD risk in T1D patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with type 1 diabetes who have well-controlled blood sugar levels and no significant complications.
Not a fit: Patients with type 2 diabetes or those with poorly controlled type 1 diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing cardiovascular diseases in individuals with type 1 diabetes.
How similar studies have performed: Previous research has indicated that understanding the unique cardiovascular risks in diabetes can lead to significant advancements in patient care, suggesting that this approach has potential for success.
Where this research is happening
Boston, United States
- Joslin Diabetes Center — Boston, United States (Active)
Researchers
- Principal investigator: King, George L — Joslin Diabetes Center
- Study coordinator: King, George L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.