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Clinical trials and research at Guy's and St Thomas' NHS Foundation Trust

• 21Clinical trials
• 1Country

Newest trials

All recruiting trials (21)

• Compare leadless and left bundle branch pacemakers for heart and valve function

  This study tests whether leadless pacemakers or left bundle branch area pacing better preserve heart and tricuspid valve function in adults needing a pacemaker.

  Recruiting Guy's and St Thomas' NHS Foundation Trust · London · NCT07534917

• Understanding why AF happens and is harder to treat in hypertrophic cardiomyopathy

  We’re testing how heart electrical signals and advanced imaging relate to atrial fibrillation in people with hypertrophic cardiomyopathy to see if treatments can be improved.

  Recruiting Guy's and St Thomas' NHS Foundation Trust · London · NCT07454135

• Low-intensity versus standard-intensity continuous dialysis for critically ill adults with acute kidney injury

  This will try giving lower-intensity continuous dialysis instead of the usual intensity to adults in intensive care with acute kidney injury to see if kidneys recover just as well with fewer side effects.

  Recruiting Guy's and St Thomas' NHS Foundation Trust · London, Greater London · NCT07447791

• Improving care for diabetes-related emotional distress in adults with type 1 diabetes

  This project will test a care pathway that trains NHS diabetes teams to spot and talk about diabetes-related emotional distress and offer an online group program for adults with type 1 diabetes who use continuous glucose monitoring.

  Recruiting at 3 sites Guy's and St Thomas' NHS Foundation Trust · Bath and 2 other locations · NCT07193446

• Seismocardiography to gauge fitness and predict outcomes before esophageal cancer surgery

  A noninvasive seismocardiography device is tested to see if it can quickly estimate a patient’s fitness and help predict surgical outcomes for adults with esophageal cancer who are planning curative treatment.

  Recruiting at 3 sites Guy's and St Thomas' NHS Foundation Trust · Guildford and 3 other locations · NCT07159711

• Co-designed pain and sedation protocol for adults on ECMO

  This project will test a co-designed pain and sedation plan to see if it's acceptable for adults receiving ECMO and similar ventilated ICU patients.

  Recruiting Guy's and St Thomas' NHS Foundation Trust · London, London · NCT07032987

• Photodynamic therapy to prevent infections after nasal surgery

  This study will test whether a preoperative nasal photodisinfection procedure lowers post‑operative infections and antibiotic use in people having elective nasal or sinus surgery.

  Recruiting Guy's and St Thomas' NHS Foundation Trust · London, London · NCT06731881

• Investigating the role of estrogen in lung disease

  This study is testing how changes in estrogen levels affect lung health in women with asthma and COPD, especially during menopause, to see if lower estrogen makes their lung function worse.

  Recruiting Guy's and St Thomas' NHS Foundation Trust · London · NCT06713512

• Support for COPD patients after hospital discharge

  This study tests whether giving COPD patients special rescue packs with medication and a management plan after they leave the hospital can help them stay healthier and avoid going back to the hospital.

  Recruiting at 10 sites Phase 3 Guy's and St Thomas' NHS Foundation Trust · Barnsley and 33 other locations · NCT06347536

• Evaluating a new breathing device for patients with neuromuscular diseases

  This study is testing a new breathing device that adjusts to patients' needs to see if it helps people with neuromuscular diseases breathe better than their current equipment.

  Recruiting at 2 sites Phase 2 Guy's and St Thomas' NHS Foundation Trust · London, London and 1 other locations · NCT06339580

• Investigating concussions and contact sports in patients with REM sleep behavior disorder

  This study is trying to see if people with REM sleep behavior disorder have more concussions and contact sports experience compared to those without the disorder.

  Recruiting Guy's and St Thomas' NHS Foundation Trust · London, London · NCT06270290

• Understanding immune profiles in healthy and diseased lungs

  This study is trying to understand how the immune system works in healthy lungs compared to those with airway diseases like COPD and asthma by looking at samples from both groups.

  Recruiting Guy's and St Thomas' NHS Foundation Trust · London, London · NCT06144476

• Investigating sedation methods for patients with Acute Respiratory Distress Syndrome on ventilators

  This study is testing whether using different sedation methods helps patients with Acute Respiratory Distress Syndrome on ventilators breathe better and feel more comfortable in the ICU.

  Recruiting Phase 2/3 Guy's and St Thomas' NHS Foundation Trust · London, London · NCT06014138

• Investigating how draining fluid from the lungs affects breathing in patients with pleural effusion

  This study is trying to see how draining fluid from the lungs affects breathing and breathlessness in adults with pleural effusion.

  Recruiting Guy's and St Thomas' NHS Foundation Trust · London, London · NCT05945043

• Measuring cancer treatment response using a specific PET scan

  This study is testing if a special PET scan can help doctors see how well treatment is working for patients with advanced lung and head and neck cancers.

  Recruiting Guy's and St Thomas' NHS Foundation Trust · London · NCT05889312

• BEARS directional-listening training to improve hearing in older children and teens with two cochlear implants

  This trial tests whether 3 months of the BEARS virtual-reality directional listening training, added to usual care, helps 8–16 year olds with two cochlear implants hear better in noisy places, reduce listening effort, and improve vocabulary and quality of life.

  Recruiting at 12 sites Guy's and St Thomas' NHS Foundation Trust · Birmingham, Birmingham and 12 other locations · NCT05808543

• Lactoferrin as an alternative to antibiotics for BV or yeast infections in women

  This study tests whether vaginal lactoferrin pessaries can replace oral antibiotics/antifungals for BV or candida infections in women.

  Recruiting Guy's and St Thomas' NHS Foundation Trust · London and 1 other locations · NCT05434104

• A registry to improve the lives of stroke survivors in South London

  This study is tracking stroke survivors in South London to see how their health and quality of life change over time.

  Recruiting at 4 sites Guy's and St Thomas' NHS Foundation Trust · London and 6 other locations · NCT05298436

• Comparing AF ablation and AV node ablation for heart failure patients

  This study tests whether a heart procedure to control rhythm or a procedure to control rate works better for heart failure patients with atrial fibrillation who are already getting special heart therapy.

  Recruiting Guy's and St Thomas' NHS Foundation Trust · London · NCT04664686

• Understanding quality of life in patients with chronic respiratory failure

  This study looks at how different treatments for chronic respiratory failure, like non-invasive ventilation, affect the daily lives and well-being of patients.

  Recruiting Guy's and St Thomas' NHS Foundation Trust · London · NCT04236726

• Improving cough assistance for patients with neuromuscular diseases

  This study is testing better ways to use cough-assisting machines for people with neuromuscular diseases to help them breathe easier and clear mucus safely.

  Recruiting Guy's and St Thomas' NHS Foundation Trust · London, London · NCT04163198

Quick answers

How many clinical trials run by Guy's and St Thomas' NHS Foundation Trust are recruiting right now?

21, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

All of them have sites in United Kingdom. Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1, Phase 2/3: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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