Understanding immune profiles in healthy and diseased lungs

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the immunopathology of airway diseases such as COPD and asthma by analyzing matched samples from the respiratory tract and circulation. Participants over 18 years old with diagnosed or suspected airway disease, as well as healthy volunteers, will be enrolled. The study will involve various assessments including lung function tests, sputum collection, and optional bronchoscopy visits to gather detailed immune response data. Participants will be monitored yearly and during clinically relevant events to track changes in their condition.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participant is willing and able to give informed consent for participation in the study
* Aged 18 years or above
* Patient: known or suspected airway disease
* Healthy volunteer: considered to be in good health with no significant comorbidity (immune disorder, cancer etc.)

Exclusion Criteria:

* Known or suspected current pulmonary tuberculosis, HIV (human immunodeficiency virus), Hepatitis B Virus, Hepatitis C Virus.
* Surgery within the preceding 6 weeks
* Participants who are pregnant
* History of psychiatric, medical, or surgical disorders that in the opinion of the chief investigator may interfere with sample collection, undergo a bronchoscopy, or may compromise study completion or data collection
* Alcohol or recreational drug abuse
* Diagnosis of immunodeficiency requiring treatment
* Unable to provide written informed consent
* Unable to read or write English
* Be considered, in the opinion of the investigator, to be an unsuitable candidate for the study

Where it's running

• Guy's & St Thomas' NHS Foundation Trust
  London, London, United Kingdom Recruiting

Study contacts

• Principal investigator: Mona Bafadhel, Prof — GSTT and KCL
• Study coordinator: Gillian Radcliffe, MRes
• Email: gillian.radcliffe@gstt.nhs.uk
• Phone: 02071888070

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.