Understanding immune profiles in healthy and diseased lungs
Study of Inflammatory and Physiological Profiles of Healthy and Diseased Lung
This study is trying to understand how the immune system works in healthy lungs compared to those with airway diseases like COPD and asthma by looking at samples from both groups.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 230 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Guy's and St Thomas' NHS Foundation Trust Academic / other |
| Locations | 1 site (London) |
| Trial ID | NCT06144476 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the immunopathology of airway diseases such as COPD and asthma by analyzing matched samples from the respiratory tract and circulation. Participants over 18 years old with diagnosed or suspected airway disease, as well as healthy volunteers, will be enrolled. The study will involve various assessments including lung function tests, sputum collection, and optional bronchoscopy visits to gather detailed immune response data. Participants will be monitored yearly and during clinically relevant events to track changes in their condition.
Who should consider this trial
Good fit: Ideal candidates include adults over 18 with diagnosed or suspected airway diseases like COPD or asthma, as well as healthy individuals without significant illness.
Not a fit: Patients with known or suspected pulmonary infections, significant comorbidities, or those unable to provide informed consent may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to a better understanding of lung diseases and improved treatment strategies for patients with airway diseases.
How similar studies have performed: While similar studies have explored immune profiles in lung diseases, this specific approach of matched sample analysis is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participant is willing and able to give informed consent for participation in the study * Aged 18 years or above * Patient: known or suspected airway disease * Healthy volunteer: considered to be in good health with no significant comorbidity (immune disorder, cancer etc.) Exclusion Criteria: * Known or suspected current pulmonary tuberculosis, HIV (human immunodeficiency virus), Hepatitis B Virus, Hepatitis C Virus. * Surgery within the preceding 6 weeks * Participants who are pregnant * History of psychiatric, medical, or surgical disorders that in the opinion of the chief investigator may interfere with sample collection, undergo a bronchoscopy, or may compromise study completion or data collection * Alcohol or recreational drug abuse * Diagnosis of immunodeficiency requiring treatment * Unable to provide written informed consent * Unable to read or write English * Be considered, in the opinion of the investigator, to be an unsuitable candidate for the study
Where this trial is running
London
- Guy's & St Thomas' NHS Foundation Trust — London, United Kingdom (Recruiting)
Study contacts
- Principal investigator: Mona Bafadhel, Prof — GSTT and KCL
- Study coordinator: Gillian Radcliffe, MRes
- Email: gillian.radcliffe@gstt.nhs.uk
- Phone: 02071888070
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.