Seismocardiography to gauge fitness and predict outcomes before esophageal cancer surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study evaluates the Seismofit device, worn while the patient is lying down, as a rapid alternative to CPET for estimating cardiorespiratory fitness in adults with esophageal cancer. The goal is to see whether Seismofit-derived fitness correlates with postoperative complications after neoadjuvant therapy and esophagectomy or esophagogastrectomy. The study leverages data from patients undergoing curative-intent treatment across several UK centers, with standard CPET measurements used for comparison where available. If successful, Seismofit could streamline baseline fitness assessment and aid patient selection and prehabilitation planning. The trial explicitly excludes patients with implanted cardiac devices or those not proceeding to resection after multidisciplinary review.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age \>=18
* Diagnosis of Oesophageal cancer (T0-4 N0-3 M0, Oesophageal / Gastro-Oesophageal Junction (GOJ) type 1-2 adenocarcinoma
* Patients being considered for curative treatment (i.e. due to undergo NAC and Oesophagectomy / Oesophago-Gastrectomy \[open / MIO / hybrid / robotic\])
* Patients able to give informed consent

Exclusion Criteria:

* Pregnant patients.
* Patients under the age of 18.
* Patients undergoing primary Oesophagectomy +/- Oesophago-Gastrectomy with no neoadjuvant therapy.
* Patients undergoing Neoadjuvant chemoradiotherapy.
* Patient's being treated with curative intent for Oesophageal Squamous cell carcinoma
* Patients that are deemed not fit or suitable for Oesophagogastric cancer resection as part of a Multi-Disciplinary Team meeting decision.
* Patients with implanted devices such as pacemakers or cardioverter-defibrillators.

Where it's running

• Guy's and St Thomas' Hospital NHS Foundation Trust
  London, United Kingdom Recruiting
• Royal Marsden NHS Foundation Trust
  London, United Kingdom Recruiting
• University Hospital Southampton
  Southampton, United Kingdom Recruiting
• Royal Surrey NHS Foundation Trust
  Guildford, United Kingdom Active not recruiting

Study contacts

• Principal investigator: Andrew Davies, MD FRCS — Guy's and St Thomas NHS Foundation Trust
• Study coordinator: Kesav Aditya Vijayagopal, DMS
• Email: kesav.vijayagopal1@nhs.net
• Phone: +447706649746

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.