Comparing AF ablation and AV node ablation for heart failure patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial involves 70 patients with heart failure and atrial fibrillation who are receiving cardiac resynchronization therapy (CRT) but have less than 95% biventricular pacing. Participants will be randomized to receive either AF catheter ablation for rhythm control or AV-node ablation for rate control. The study will evaluate the outcomes at six months through echocardiography and clinical assessments, including various tests to measure heart function and quality of life. The goal is to determine which approach is more effective in managing their condition.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Ability to provide informed consent to participate and willing to comply with the clinical investigation plan and follow-up schedule.
* QRS duration \>120ms on surface ECG, severe left ventricular systolic impairment (EF≤35%) and clinical symptoms of heart failure despite optimum medical therapy (NYHA class II-IV) at time of CRT implant or upgrade
* Successful CRT implant or upgrade including atrial lead
* Biventricular pacing percentage \<95% secondary to atrial fibrillation at least 3 months post implant or upgrade
* Clinically indicated for AV node ablation

Exclusion Criteria:

* Life expectancy \<1 year
* Presence of atrial or ventricular thrombus
* Permanent atrial fibrillation
* Mechanical aortic valve replacement
* Severe peripheral vascular disease
* Female participants who are pregnant, lactating or planning pregnancy during the course of the study.
* Participation in other studies with active treatment / investigational arm

Where it's running

• Guys and St Thomas' NHS Foundation Trust
  London, United Kingdom Recruiting

Study contacts

• Principal investigator: Christopher A Rinaldi — Guy's and St Thomas' NHS Foundation Trust
• Study coordinator: Christopher A Rinaldi
• Email: aldo.rinaldi@kcl.ac.uk
• Phone: 02071889257

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Village-doctor–led telehealth care to improve outcomes for AF and HF in older adults

  A village doctor–led telemedicine program will try to improve heart failure management in rural AF patients aged 65–80 compared with usual care.

  Recruiting at 3 sites Jiangsu Taizhou People's Hospital · Yancheng, Dongtai and 2 other locations · NCT07492524

• Village doctor–led telehealth care to prevent heart failure in AF patients

  A village doctor–led telehealth program tests whether integrated, guideline-based care can help older adults with atrial fibrillation in rural China stay healthier and avoid heart failure compared with usual care.

  Recruiting at 3 sites Jiangsu Taizhou People's Hospital · Yancheng, Dongtai and 2 other locations · NCT07492498

• RHYthm and Myocardial Function Relationship in Heart Disease

  This study tests how heart rhythm patterns relate to heart muscle function in adults with arrhythmias or cardiomyopathy.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma · NCT07491237

• Longitudinal Assessment of Cardiac MRI Microstructure in Patients and Healthy People

  This study tests advanced, non-contrast and extended clinical cardiac MRI techniques to see how heart tissue features differ between people with heart disease and healthy individuals.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07081711

• Using BIOMONITOR IV to track heart rhythm and warning signs in people with heart failure

  This project will test whether a small implanted monitor called BIOMONITOR IV can track irregular heartbeats and body signals in people with heart failure who do not have ICD/CRT devices to see if it can warn doctors before the heart failure gets worse.

  Recruiting Biotronik SE & Co. KG · Genk and 1 other locations · NCT06989580

• Understanding brain and heart injuries after bleeding in the brain

  This study looks at how bleeding in the brain affects both the brain and the heart in adults to better understand the connection between these injuries.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT06906432

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.