Investigating sedation methods for patients with Acute Respiratory Distress Syndrome on ventilators

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study examines the effects of different sedation methods on patients with Acute Respiratory Distress Syndrome (ARDS) who are on mechanical ventilation in the Intensive Care Unit (ICU). It compares intravenous sedation with inhaled volatile sedation to assess their impact on breathing efforts and lung function. The study involves measuring patients' respiratory parameters while they receive both types of sedation, allowing researchers to determine which method better supports lung function and patient comfort. A total of 20 patients will participate, with careful monitoring of their sedation levels and breathing responses throughout the process.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients admitted to the Intensive Care Unit (ICU)
* ARDS
* Invasive mechanical ventilation (IMV)
* Spontaneous breathing in pressures support mode (PSV) for less than or equal to 48 hours
* Sedated with intravenous sedation (ie. propofol and / or midazolam and fentanyl or alternate short acting opioid)
* Anticipated to remain on IMV and PSV and with a stable sedation score for a further 24 hours without planned sedation interruption / spontaneous breathing trial or other significant change in the level of ventilator support
* Not receiving / anticipated to receive paralysis
* In supine position

Exclusion Criteria:

* Personal or family history of malignant hyperpyrexia
* Known or suspected elevated intracranial pressure
* High dose vasopressors (ie. Noradrenaline \> 0.3mcg/kg/min or equivalent)
* Contra-indication to oesophageal balloon (i.e. oesophageal / upper gastro-intestinal pathology)
* Pregnancy
* High dose oral sedatives (e.g. benzodiazepines) or opioids (e.g. oxycodone / oral morphine) which may affect respiratory drive

Where it's running

• Guy's & St Thomas' NHS Foundation Trust
  London, London, United Kingdom Recruiting

Study contacts

• Principal investigator: Guy Glover — Guy's and St Thomas' NHS Foundation Trust
• Study coordinator: Guy Glover
• Email: guy.glover@gstt.nhs.uk
• Phone: 00447879696250

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Height measurement methods to guide ventilator settings in ARDS

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.