Evaluating a new breathing device for patients with neuromuscular diseases

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study assesses the safety and efficacy of volume-targeted non-invasive ventilation (VT-NIV) in patients with neuromuscular diseases who require breathing support. Participants will be admitted for two nights, during which their carbon dioxide control will be evaluated using their current fixed non-invasive ventilation device. On the second night, they will switch to the VT-NIV mode, which adjusts pressures based on patient needs to deliver a target volume of air. The goal is to gather data that will inform a future randomized controlled trial comparing VT-NIV with traditional fixed ventilation methods.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Slowly progressive neuromuscular disease
* Established on fixed bi-level ventilation
* Documented clinical respiratory stability by supervising clinician (no hospitalizations, respiratory infections or change to ventilator settings in preceding 6 weeks)

Exclusion Criteria:

* Rapidly progressive neuromuscular disease
* Decompensated respiratory failure (pH \< 7.35)
* Pregnancy
* Aged \<18, \>80
* Poor adherence to NIV (\<4hrs per night)
* Significant physical or psychiatric co-morbidity that would prevent compliance with trial protocol

Where it's running

• Guy's & St Thomas' NHS Foundation Trust
  London, London, United Kingdom Recruiting
• Guy's and St. Thomas NHS Foundation Trust
  London, United Kingdom Recruiting

Study contacts

• Study coordinator: Patrick Murphy
• Email: Patrick.murphy@gstt.nhs.uk
• Phone: 02071888070

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.