Improving cough assistance for patients with neuromuscular diseases

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on optimizing the use of mechanical insufflation-exsufflation (MIE) devices for patients with neuromuscular diseases who experience respiratory muscle weakness. It aims to determine the most effective techniques and settings for these devices to enhance airway secretion clearance while minimizing risks such as lung collapse and impaired blood flow. The study will involve patients with stable or slowly progressive neuromuscular conditions and will assess their respiratory function and secretions. By refining the use of MIE, the study seeks to improve patient outcomes in respiratory health.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Stable or slowly progressive neuromuscular disease
* Respiratory muscle weakness (FVC \<60%, snip \<60%, sleep disordered breathing)
* Clinical evidence of respiratory secretions or cough peak expiratory flow \<270 and history of lower respiratory tract infection
* Documented clinical stability by supervising clinician

Exclusion Criteria:

* Rapidly progressive neuromuscular disease (such as motor neuron disease)
* Decompensated respiratory failure (pH \< 7.35)
* Pregnancy
* Aged \<18
* Change in ventilator settings in preceding 4 weeks
* Significant physical or psychiatric co-morbidity that would prevent compliance with trial protocol

Where it's running

• Guys & St. Thomas' NHS Foundation Trust
  London, London, United Kingdom Recruiting

Study contacts

• Study coordinator: Patrick Murphy, PhD
• Email: patrick.murphy@gstt.nhs.uk
• Phone: +442071888070

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.