Sponsor or institution
Clinical trials and research at Children's Research Institute
As of November 12, 2026, Find a Trial lists 136 NIH-funded research projects at this institution, with $70.7 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 136NIH research projects
NIH-funded research (newest 40 of 136)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Collaborative Pediatric Critical Care Research Network: personalized care for septic kids
A nationwide network is testing personalized treatment approaches for children with sepsis-related organ failure to improve outcomes.
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NextGen CAR-T for childhood solid cancers
Aims to develop next-generation engineered T-cell therapies to treat pediatric solid tumors by identifying new targets and improving T-cell function.
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Guided IDD research at DC partner centers to understand and improve developmental disorders in children
A $1.19 million NIH grant supports coordinated, translational research across four DC medical centers to uncover causes and develop new ways to prevent or lessen intellectual and developmental disabilities in children.
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Viral Factors in the Prenatal Brain: How HEXB and Lysosomes Shape Baby Brain Health
This grant explores how a mother’s viral infection during pregnancy can affect a baby’s brain, focusing on a specific enzyme (HEXB) and lysosome function to understand and prevent brain injuries.
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Opioid exposure in pregnancy: how it affects placental health and baby outcomes
A study looking at how opioids taken during pregnancy might change the placenta and impact the baby’s growth and health.
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Enhanced detection of bone age anomalies to help diagnose childhood growth disorders
A new AI tool will help doctors look at left-hand bone-age X-rays to better diagnose growth disorders in children.
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Delta brain rhythms in Angelman syndrome
Scientists will study unusual brain wave patterns in Angelman syndrome to understand how these signals relate to behavior and guide future treatments for affected children and adults.
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Defining how the immune system and kidney cells interact in ARPKD
A scientist is studying how genetic changes in ARPKD affect kidney and immune cell interactions, with the aim of finding new ways to help affected children.
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Genetic enhancers guiding lip and palate formation in babies
This project looks for key DNA elements that control when and where genes involved in lip and palate development are turned on in developing embryos.
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Improving risk prediction for children who call EMS with non‑emergent complaints
A pediatric-focused project to refine and pilot a risk score (POPS) so EMS workers can safely decide which kids truly need ambulance transport to the ED.
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Tracking brain stressors from pregnancy to child development
This grant follows mothers and their children to see how pregnancy stress and worry affect a child's brain development and later behavior.
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Mindfulness program in clinics to help mood and diabetes management for teens with Type 1 diabetes
A practical mindfulness-based program delivered in clinics aims to help mood problems and improve diabetes management for young people with Type 1 diabetes.
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Measuring What Youth with Variations in Sex Traits Need for Care
A patient-friendly look at a project to understand and improve how care is planned for young people with VST by listening to their needs and preferences.
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Alliance for Pediatric Device Innovation
A pediatric device project aims to move innovative medical devices for kids toward real-world use.
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Emerging Challenges in Newborn Screening: Understanding Uncertain Prognoses for Toddlers and Kids
This research looks at how giving families uncertain predictions after newborn screening affects children and their families.
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Circadian clocks and NG2-glia regenerative potential in brain injury
A scientist is studying how the body's 24-hour clock affects brain repair cells (NG2-glia) after traumatic brain injury in young people and adults.
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Children’s Oncology Group Clinical Trials leadership and oversight
A national network is coordinating and guiding pediatric cancer clinical trials to improve treatment, care, and survival for children and teens with cancer.
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Protecting thalamic neurons after cardiac arrest with ethosuximide
A new, patient-friendly approach looks at giving ethosuximide after cardiac arrest to protect brain cells that help consciousness, aiming to improve recovery for survivors.
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Combining retinoic acid with proteasome inhibitors to treat neuroblastoma
This NIH grant tests a combination of retinoic acid and proteasome inhibitors to treat neuroblastoma in children.
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Care needs for young people born with variations in sex traits
This project will create questionnaires to learn what care young people with variations in sex traits need and prefer.
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Integrated sleep-cycle check for preterm babies in the NICU
A small, non-invasive study will track how sleep patterns mature in very premature babies in the NICU to help predict later brain development.
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Early Executive Function Help for Young Children with Disabilities
A new classroom program helps preschoolers with disabilities build better executive skills to support their mental health and daily functioning.
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Sex differences in growth problems from pediatric Crohn’s disease (Part 2)
A pediatric Crohn’s disease study explores why boys may be more affected by growth problems and what this means for treatment.
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What the amygdala does as kids grow up
A study aims to understand how a part of the brain called the amygdala changes from adolescence into adulthood and how this affects social and emotional behavior in young people.
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Understanding how early alcohol exposure affects brain function and how APOE-based therapies might help
This study looks at how prenatal alcohol exposure can cause long-lasting brain and behavior problems and tests a therapy that targets APOE signaling in the motor area of the brain.
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Image-guided robotic guidance to place pediatric orthopedic implants with less radiation
A new robot-assisted, low-dose 3D guidance system helps surgeons place pediatric implants accurately while reducing radiation exposure.
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Intravenous citrulline for sickle cell VOC treatment in kids and adults
A phase 2 trial tests whether IV citrulline added to usual care can reduce pain and hospital stay for people with sickle cell vaso-occlusive crisis.
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How genes and pregnancy vitamin A levels can cause heart birth defects
This project examines how a mother's vitamin A levels and a baby's change in the HECTD1 gene together can lead to congenital heart defects in developing babies.
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Preventing fall asthma attacks in city children with one seasonal anti-IgE shot
Giving one anti-IgE (omalizumab) dose before the fall to children with allergic asthma who live in urban areas to try to reduce asthma attacks.
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Maternal Depression and How Baby’s Brain Develops Under Different Treatments
This project looks at how a mother’s depression and the medicines she uses during pregnancy might affect a baby’s brain development and behavior.
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Plastic chemicals in blood products and transfusion safety
This research tests whether chemicals that leach from plastic medical devices make blood transfusions and heart surgery recovery riskier for patients.
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Ultrasound-enhanced guidance for minimally invasive surgery
This project creates a system that overlays ultrasound onto the surgeon’s laparoscopic video to help surgeons better see internal anatomy during operations on children.
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Immune-cell exosomes and microRNAs against childhood neuroblastoma
This project tests whether tiny particles called exosomes from activated natural killer immune cells, and the microRNAs they carry, can help kill neuroblastoma tumors in children.
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How GLI2-driven medulloblastoma starts and grows in children
Looking at whether blocking a cancer growth pathway called MAPK can slow or stop aggressive GLI2-driven medulloblastoma in children.
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Postnatal low oxygen and heart immaturity impacting recovery after pediatric heart surgery
Researchers will study how low oxygen levels after birth and immature heart cells affect recovery after heart surgery in children with congenital heart disease.
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How children's muscles repair themselves and what that could mean for muscle disease
This project looks at why children's muscles heal so well and how that knowledge could help kids with early-onset muscle diseases like Duchenne muscular dystrophy.
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Hospital-to-Home: helping kids with asthma stay out of the hospital
A pragmatic trial tests a patient-centered program to improve asthma care for children after hospitalization, aiming to reduce readmissions and disparities.
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Age-appropriate heart medication strategies for children with congenital heart disease
This work looks at how common heart medicines affect babies, children, and teens so doctors can choose safer, age-tailored treatments.
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Palliative care and advance planning for children with rare diseases and their families
This project offers a family-centered advance care planning program to help parents of young children with rare diseases address palliative care needs and make future medical decisions.
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Using emergency-department tech and two-way texting to find and treat STIs in teens
This project uses electronic health records and two-way text messages to help emergency departments find and treat sexually transmitted infections in adolescents, especially Black and Hispanic youth.
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