Sex differences in growth problems from pediatric Crohn’s disease (Part 2)
Official title: Sex Differences in Statural Growth Impairment in Pediatric Crohn's Disease: Part 2
Funded at Children's Research Institute · NIH-11353941 · Data updated 2026-11-12
A pediatric Crohn’s disease study explores why boys may be more affected by growth problems and what this means for treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Research Institute NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | September 11, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $663,421 |
| NIH project number | 5R01HD111638-04 |
| Project ID | NIH-11353941 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children with Crohn’s disease, particularly males, who have growth impairment or are at risk for short stature.
✕Less likely to help
Patients without growth impairment or those not meeting study criteria may not experience direct benefits.
What this research studies
This study looks at how inflammation from Crohn’s disease affects growth-related hormones in children, especially boys. It builds on previous work to understand why growth impairment persists despite therapy and how sex-specific biology influences growth outcomes. Researchers will analyze patient data and inflammatory markers to identify endocrine changes linked to growth, aiming to guide better treatments for final height. The focus is on translating findings into strategies that support normal growth alongside Crohn’s disease control.
Why it matters
Potential benefit: If successful, findings could lead to targeted therapies that improve growth and final height for children with Crohn’s disease.
How similar studies have gone: Previous Part 1 showed sex-specific hormonal differences; Part 2 aims to validate and extend those findings.
Where this research is happening
-
Children's Research Institute
Washington, United States Active
Researchers
- Principal investigator: Gupta, Neera — Children's Research Institute
- Study coordinator: Gupta, Neera
Related research
Other NIH-funded projects on the same topics.
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Site-specific gene-microbial interactions in children with Crohn’s disease
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This project looks at how a specific genetic variation affects how Crohn’s disease works and whether targeting that pathway could lead to new treatments.
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This study looks at how the IL-23 blocking therapy risankizumab affects immune cells in people with Crohn’s disease.
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Metabolic signatures that predict outcomes in children with Crohn's
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.