Delta brain rhythms in Angelman syndrome
Official title: Delta oscillations in Angelman syndrome
Funded at Children's Research Institute · NIH-11445746 · Data updated 2026-11-12
Scientists will study unusual brain wave patterns in Angelman syndrome to understand how these signals relate to behavior and guide future treatments for affected children and adults.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Research Institute NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | September 15, 2026 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $1,505,552 |
| NIH project number | 1RF1NS144086-01A1 |
| Project ID | NIH-11445746 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children with Angelman syndrome and adults with the condition who participate in or contribute to related studies, plus suitable human samples or data as part of the project.
✕Less likely to help
Most participants will contribute to knowledge rather than receive a direct treatment in this study.
What this research studies
Angelman syndrome is a genetic condition that affects development and behavior. This project will look closely at two types of delta brain activity in both children with Angelman syndrome and a mouse model, to see how each relates to different behaviors. Researchers will test how periodic delta waves and the slower background activity arise and what brain mechanisms drive them, then connect these findings to observed behaviors. The goal is to provide mechanistic insights that can inform preclinical drug development and improve our understanding of brain function in Angelman syndrome.
Why it matters
Potential benefit: Better understanding of brain signals in Angelman syndrome could guide the design of targeted therapies in the future.
How similar studies have gone: Previous work has linked delta EEG features to Angelman syndrome, and this project aims to clarify mechanisms, building on those findings.
Where this research is happening
-
Children's Research Institute
Washington, United States Active
Researchers
- Principal investigator: Sidorov, Michael S — Children's Research Institute
- Study coordinator: Sidorov, Michael S
Related research
Other NIH-funded projects on the same topics.
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Genome editor therapy for Angelman syndrome in young children
A University of North Carolina team is exploring a gene-editing approach to turn on the silent UBE3A gene in people with Angelman syndrome to reduce symptoms.
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MicroRNA pathways in Angelman Syndrome: novel targets for therapy
A small study explores how specific microRNAs may influence Angelman syndrome and whether targeting them could lead to new treatments.
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Targeting the stress response in Angelman syndrome
Aims to understand how loss of a brain gene called UBE3A disrupts pathways in Angelman syndrome and to design therapies that calm the stress response in affected neurons.
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Small molecule therapy to turn on the paternal UBE3A gene in Angelman syndrome
A small molecule drug is being developed to turn on the paternal UBE3A gene in Angelman syndrome, with the goal of improving brain function.
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UBE3A mosaicism and Angelman syndrome phenotypes
A study from UNC Chapel Hill will explore how the mix of neurons with active paternal UBE3A affects Angelman syndrome symptoms using a special mouse model and gene therapy tools.
-
How body‑sensing nerves affect walking in Angelman syndrome
This project looks at whether problems with a nerve sensor called PIEZO2 cause balance and walking problems in people with Angelman syndrome.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.