Preventing fall asthma attacks in city children with one seasonal anti-IgE shot
District of Columbia Childhood Asthma in Urban Settings - Clinical Research Center
Giving one anti-IgE (omalizumab) dose before the fall to children with allergic asthma who live in urban areas to try to reduce asthma attacks.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Research Institute NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-11319780 on NIH RePORTER |
What this research studies
If your child joins, they may get a single dose of anti-IgE (omalizumab) in the fall and researchers will follow how often colds and asthma flare-ups happen. The team will collect nasal samples during viral colds to study how the nose germs and inflammation change with and without the treatment. This is a pilot effort at a Washington, DC site that links clinical care with lab testing to learn why seasonal exacerbations happen. Results will help plan larger trials and may point to ways to prevent falls with targeted medicine.
Who could benefit from this research
Good fit: Children in urban Washington, DC areas who have allergic, exacerbation-prone asthma (roughly preschool to elementary age) and a history of fall worsening are the best candidates.
Not a fit: Children without allergic sensitization, with non-allergic asthma, adults, or those not prone to seasonal exacerbations are unlikely to benefit from this single-dose seasonal approach.
Why it matters
Potential benefit: If successful, this approach could lower fall-time asthma attacks, emergency visits, and missed school days for allergic urban children.
How similar studies have performed: Anti-IgE therapy has reduced asthma attacks in prior trials, but using a single seasonal dose in the fall is a newer, pilot-tested approach with limited existing data.
Where this research is happening
Washington, United States
- Children's Research Institute — Washington, United States (Active)
Researchers
- Principal investigator: Sheehan, William James — Children's Research Institute
- Study coordinator: Sheehan, William James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.