NextGen CAR-T for childhood solid cancers
Official title: NextGen - CRI
Funded at Children's Research Institute · NIH-11539614 · Data updated 2026-11-12
Aims to develop next-generation engineered T-cell therapies to treat pediatric solid tumors by identifying new targets and improving T-cell function.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Research Institute NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | June 22, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $1,626,552 |
| NIH project number | 3OT2CA278700-01S4 |
| Project ID | NIH-11539614 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are pediatric patients with solid tumors (e.g., brain tumors, sarcomas) who may benefit from future CAR-T therapies.
✕Less likely to help
Patients whose tumors lack suitable targets or who cannot tolerate future cellular therapies may not benefit.
What this research studies
This program focuses on creating advanced CAR-T cell therapies for children with solid cancers, aiming to overcome tumor defenses and heterogeneity. Researchers will study primary tumor samples to discover targets and understand the tumor microenvironment, while closely linking laboratory work with clinical development. The goal is to move toward routine, safer, and more effective T-cell treatments for pediatric patients within the next decade.
Why it matters
Potential benefit: If successful, children with difficult-to-treat solid tumors could receive more effective, durable, and less toxic T-cell therapy.
How similar studies have gone: Previous research in CAR-T therapy has shown promise in hematologic cancers and is being extended to solid tumors with this approach.
Where this research is happening
-
Children's Research Institute
Washington, United States Active
Researchers
- Principal investigator: Bollard, Catherine M. — Children's Research Institute
- Study coordinator: Bollard, Catherine M.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.