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Clinical trials and research at Amsterdam UMC, location VUmc

• 48Clinical trials
• 11Countries

Newest trials

All recruiting trials (48)

• Back on Track: Reintegration help for workers with musculoskeletal disorders

  A computer-assisted reintegration plan is being tested to see if it helps employees on sick leave due to musculoskeletal problems in the Netherlands return to work sooner and reduce related costs.

  Recruiting Amsterdam UMC, location VUmc · Utrecht · NCT07793526

• Irreversible Electroporation for Recurrent Pelvic Tumors

  This study tests whether using irreversible electroporation (IRE) is safe and helps control recurrent pelvic tumors in adults who can’t have other local treatments.

  Recruiting Amsterdam UMC, location VUmc · Amsterdam, North Holland · NCT07782164

• CT-guided implantation of phosphorus-32 microparticles for non-progressive locally advanced pancreatic cancer

  This trial tests whether placing phosphorus-32 microparticles directly into the pancreatic tumor can help control locally advanced disease in adults who have not progressed after chemotherapy.

  Recruiting Phase 1/2 Amsterdam UMC, location VUmc · Amsterdam, North Holland · NCT07595835

• Mechanical left ventricular unloading with PulseCath iVAC2L during complex high-risk PCI

  This trial will test whether using the PulseCath iVAC2L pump to support the heart during complex, high-risk PCI helps people with poor left ventricular function avoid low blood pressure and other complications.

  Recruiting at 8 sites Amsterdam UMC, location VUmc · Amsterdam and 7 other locations · NCT07380217

• Magnetic brain stimulation for fatigue and brain fog in long COVID

  This trial will see if repetitive transcranial magnetic stimulation (rTMS) can reduce severe fatigue and improve concentration in adults with long COVID.

  Recruiting Amsterdam UMC, location VUmc · Amsterdam · NCT07278206

• Adaptive compression anastomosis for anterior resection in sigmoid and upper rectal cancer or premalignant lesions

  This study will test a removable silicone compression ring (C-REX RectoAid Cath) to create the bowel connection during elective anterior resection for people with sigmoid or proximal rectal cancer or premalignant lesions.

  Recruiting Amsterdam UMC, location VUmc · Amsterdam · NCT07056374

• Targeted magnetic stimulation of the precuneus to slow cognitive decline in Alzheimer's

  This will try repetitive magnetic brain stimulation of the precuneus to see if it slows memory and thinking decline in people aged 50–85 with biomarker-confirmed mild Alzheimer's.

  Recruiting Amsterdam UMC, location VUmc · Amsterdam · NCT07036328

• Effects of sodium intake on kidney function changes with ertugliflozin in type 2 diabetes

  This study is testing how different amounts of salt in the diet affect kidney function in people with type 2 diabetes who are taking the medication ertugliflozin.

  Recruiting at 2 sites Phase 4 Amsterdam UMC, location VUmc · Denver, Colorado and 1 other locations · NCT06983054

• Neoadjuvant gemcitabine and cisplatin with perioperative pembrolizumab vs upfront surgery for cancers of the bile ducts

  This trial tests whether giving chemotherapy with pembrolizumab before surgery helps people with resectable or borderline resectable extrahepatic cholangiocarcinoma see if they have better outcomes than going straight to surgery.

  Recruiting Phase 2/3 Amsterdam UMC, location VUmc · Amsterdam · NCT06923475

• Chemoradiotherapy followed by durvalumab for stage III lung cancer

  This study is testing if giving a combination of chemotherapy, radiation, and the immunotherapy durvalumab can help people with stage III lung cancer who couldn't initially have surgery, to see if it improves their chances of survival.

  Recruiting Phase 4 Amsterdam UMC, location VUmc · Amsterdam · NCT06908070

• Does a 5-second ventilation pause improve ventilation success in mechanical chest compressions?

  This study tests whether increasing the ventilation pause from 3 to 5 seconds during mechanical chest compressions helps ambulance teams deliver two ventilations more reliably during CPR for adults with cardiac arrest.

  Recruiting at 2 sites Amsterdam UMC, location VUmc · Amsterdam, North Holland and 1 other locations · NCT06824961

• Improving medication prescribing for older nursing home residents

  This study tests if training healthcare workers to better manage medications can help older nursing home residents with serious illnesses receive care that matches their comfort and quality of life goals.

  Recruiting at 3 sites Amsterdam UMC, location VUmc · Apeldoorn, Gelderland and 6 other locations · NCT06731361

• Improving treatment-resistant PTSD with a glucocorticoid receptor blocker

  This study is testing if a medication called mifepristone can help adults with treatment-resistant PTSD feel better by blocking the effects of stress hormones.

  Recruiting Phase 2 Amsterdam UMC, location VUmc · Amsterdam, North Holland · NCT06689254

• Metformin before pre-surgery chemoradiotherapy to boost immune activity in oesophageal adenocarcinoma

  This trial will try two weeks of metformin before neoadjuvant chemoradiotherapy to see if it activates the tumour immune environment in adults with stage II–III oesophageal adenocarcinoma.

  Recruiting Phase 2 Amsterdam UMC, location VUmc · Amsterdam and 1 other locations · NCT06687876

• Sotatercept to support right ventricular function in pulmonary arterial hypertension

  This research will try sotatercept injections in adults with PAH to see if the medicine helps the right side of the heart work better.

  Recruiting Phase 4 Amsterdam UMC, location VUmc · Amsterdam, North Holland · NCT06658522

• Identifying biomarkers for progressive pulmonary fibrosis in lung disease patients

  This study is trying to find early signs that can help predict if adults with certain lung diseases will develop progressive pulmonary fibrosis over the next five years.

  Recruiting Amsterdam UMC, location VUmc · Amsterdam, North Holland · NCT06644144

• Impact of Functional Power Training on Activity in Children with Cerebral Palsy

  This study tests if Functional Power Training can help children with cerebral palsy, aged 4 to 12, be more active and improve their walking and endurance compared to regular care.

  Recruiting at 8 sites Amsterdam UMC, location VUmc · Emmen, Drenthe and 9 other locations · NCT06640894

• Single-dose preoperative radiotherapy and repeat breast surgery for recurrent breast cancer

  This study is testing if a single dose of targeted radiation before surgery can help older patients with recurring breast cancer have better treatment results and improve their appearance after surgery.

  Recruiting Phase 2 Amsterdam UMC, location VUmc · Amsterdam · NCT06640881

• Evaluating a new immuno-adjuvant for colorectal liver metastases after ablation treatments

  This study is testing a new treatment called IP-001 to see if it can boost the immune response and help people with colorectal liver metastases feel better after they have undergone ablation therapies.

  Recruiting Phase 1/2 Amsterdam UMC, location VUmc · Amsterdam, North Holland · NCT06630624

• Advanced imaging techniques for brain tumor surgery

  This study is testing if advanced imaging techniques can help doctors remove brain tumors more accurately in patients with certain types of glioblastoma to improve their outcomes.

  Recruiting Amsterdam UMC, location VUmc · Amsterdam, North Holland · NCT06623565

• Treatment for Multiple Sclerosis Using Stem Cell Transplantation

  This study is testing the long-term effects of a stem cell treatment for people with active relapsing-remitting multiple sclerosis to see how it impacts their health over five years.

  Recruiting at 2 sites Amsterdam UMC, location VUmc · Amsterdam and 1 other locations · NCT06567197

• Evaluating T Cell Changes in Lung Cancer with PET Imaging

  This study is testing two new imaging methods to see how T cells change in people with non-small cell lung cancer after they receive chemo-immunotherapy.

  Recruiting Amsterdam UMC, location VUmc · Amsterdam, North Holland · NCT06457789

• Postoperative treatment for recurrent breast cancer with or without heat therapy

  This study is testing whether adding heat therapy to re-irradiation after surgery helps people with recurrent breast cancer feel better and have fewer side effects.

  Recruiting Amsterdam UMC, location VUmc · Amsterdam · NCT06452485

• Leg-worn smart cueing device to reduce freezing of gait in Parkinson's

  This tests whether a leg-worn device that automatically detects freezing of gait and gives rhythmic sound or vibration cues helps people with Parkinson's who experience daily freezing.

  Recruiting Amsterdam UMC, location VUmc · Nijmegen, Gelderland and 1 other locations · NCT06416345

• Neoadjuvant treatment for borderline resectable pancreatic cancer

  This study is testing a new combination of chemotherapy, immunotherapy, and radiation before surgery to see if it can help people with borderline resectable pancreatic cancer live longer and have better treatment results.

  Recruiting at 3 sites Phase 1/2 Amsterdam UMC, location VUmc · Amsterdam and 3 other locations · NCT06384560

• Understanding the incidence and outcomes of trilateral retinoblastoma

  This study looks at how common trilateral retinoblastoma is and how well patients survive, comparing data from different countries to see if there are differences based on income levels.

  Recruiting Amsterdam UMC, location VUmc · Amsterdam, North Holland · NCT06367530

• Microcirculation, Dialysis Modality, and Sequestered Salt in Dialysis Patients

  This study tests five dialysis approaches (different modes and dialysate sodium levels) to see how they affect tiny blood vessel function and hidden salt in adult dialysis patients.

  Recruiting at 2 sites Amsterdam UMC, location VUmc · Amstelveen, North Holland and 1 other locations · NCT06327750

• High-intensity interval training to improve fitness in brain tumor patients

  This study is testing if high-intensity interval training can help adults with stable brain tumors feel fitter compared to those who don't exercise.

  Recruiting Amsterdam UMC, location VUmc · Amsterdam · NCT06282562

• Creating AI tools to predict vascular disease risk and progression

  This study is trying to create smart computer tools that can predict the risk and progression of vascular diseases like abdominal aortic aneurysm and peripheral arterial disease by looking at medical images and patient history.

  Recruiting at 6 sites Amsterdam UMC, location VUmc · Helsinki and 5 other locations · NCT06206369

• Comparing two treatments for colorectal liver metastases

  This study is testing whether a new treatment called irreversible electroporation works better than stereotactic body radiotherapy for people with hard-to-treat colorectal cancer that has spread to the liver.

  Recruiting Phase 2/3 Amsterdam UMC, location VUmc · Amsterdam, North Holland · NCT06185556

• YoPA: Youth-led changes to neighborhood spaces and daily routines to improve activity, sleep, and screen habits

  This project will try a youth-centred co-creation approach to change social and physical environments so 12–18 year-olds in disadvantaged urban areas are more active, sleep better, and use screens less harmfully.

  Recruiting at 4 sites Amsterdam UMC, location VUmc · Odense and 3 other locations · NCT06181162

• Using machine learning to improve blood culture testing in emergency departments

  This study is testing whether a new machine learning tool can help doctors in the emergency department decide when blood tests are really needed for adult patients, to see if it can reduce unnecessary tests while keeping patients safe.

  Recruiting Amsterdam UMC, location VUmc · Amsterdam · NCT06163781

• Balloon Pulmonary Angioplasty for Chronic Thromboembolic Disease

  This study tests if Balloon Pulmonary Angioplasty can improve the quality of life and exercise ability for people with chronic thromboembolic pulmonary disease who don't have high blood pressure in their lungs.

  Recruiting Amsterdam UMC, location VUmc · Amsterdam, North Holland · NCT06090838

• Preventing cognitive decline and unemployment in people with multiple sclerosis

  This study is testing two new programs to see if they can help people with multiple sclerosis keep their thinking skills sharp and stay employed, compared to regular care.

  Recruiting Amsterdam UMC, location VUmc · Amsterdam · NCT06068582

• Combining brain stimulation and cognitive training to improve thinking skills in glioma patients

  This study is testing if combining brain stimulation with thinking skills training can help adults with glioma improve their cognitive abilities.

  Recruiting Amsterdam UMC, location VUmc · Amsterdam · NCT06043765

• Comparing two types of brain stimulation for treatment resistant depression

  This study is testing a new type of brain stimulation treatment for people with depression who haven't found relief from other therapies to see if it works better than the standard treatment.

  Recruiting at 3 sites Amsterdam UMC, location VUmc · Nijmegen, GL and 3 other locations · NCT05900271

• Comparing two methods for assessing fertility in women

  This study is testing whether a common fertility test using oil-based contrast can help women have more babies compared to a foam-based test.

  Recruiting Amsterdam UMC, location VUmc · Amsterdam · NCT05882188

• Neoadjuvant therapy followed by local treatment for recurrent colorectal liver metastases

  This study is testing if giving a new treatment before local therapy can help people with recurrent colorectal liver cancer live longer compared to getting local therapy right away.

  Recruiting Phase 3 Amsterdam UMC, location VUmc · Amsterdam · NCT05861505

• Comparing Rituximab and Ocrelizumab for Treating Relapsing Multiple Sclerosis

  This study is testing if rituximab works just as well as ocrelizumab for treating relapsing multiple sclerosis in adults.

  Recruiting Phase 3 Amsterdam UMC, location VUmc · Amsterdam · NCT05834855

• Imaging changes in T-cell activity after anti-PD-1 therapy in lung cancer

  This study is testing if special imaging can show changes in T-cell activity in patients with advanced lung cancer after they receive a specific treatment to see if it helps doctors better understand their tumors.

  Recruiting Amsterdam UMC, location VUmc · Amsterdam · NCT05701176

• Training to improve calf muscle strength and length in children with spastic paresis

  This study tests if a special training program can make calf muscles stronger and longer in children with spastic paresis to help them walk and run better.

  Recruiting Amsterdam UMC, location VUmc · Amsterdam · NCT05649930

• Single-dose preoperative radiation for low-risk breast cancer

  This study is testing if a single dose of MRI-guided radiation before surgery can help people with low-risk breast cancer and improve their treatment results.

  Recruiting at 6 sites Amsterdam UMC, location VUmc · Sydney and 6 other locations · NCT05350722

• Using rTMS to help patients with OCD who don't respond to therapy

  This study is testing if a new brain treatment called rTMS can help adults with OCD who haven't improved with regular therapy.

  Recruiting at 2 sites Phase 3 Amsterdam UMC, location VUmc · Amsterdam, North Holland and 7 other locations · NCT05331937

• Preventing constipation caused by opioids in advanced cancer patients

  This study is testing whether magnesium hydroxide can help prevent constipation caused by opioid pain medications in advanced cancer patients better than a standard treatment.

  Recruiting at 13 sites Phase 4 Amsterdam UMC, location VUmc · Almere Stad, Flevoland and 12 other locations · NCT05216328

• Registry of patients who have had coronary artery procedures

  This study collects information from patients who have had heart procedures to better understand how these procedures relate to coronary artery disease.

  Recruiting Amsterdam UMC, location VUmc · Amsterdam · NCT04815928

• Evaluating heart patients with previous bypass surgery for graft issues and heart disease progression

  This study is trying to see how heart patients who had bypass surgery and are having chest pain again are doing over time, especially looking at issues with their grafts and heart disease.

  Recruiting Amsterdam UMC, location VUmc · Amsterdam · NCT04772768

• Intradermal treatment for advanced melanoma

  This study is testing a new immune booster called IMO-2125 to see if it helps people with advanced melanoma feel better after surgery.

  Recruiting Phase 2 Amsterdam UMC, location VUmc · Amsterdam · NCT04126876

• Comparing the use of orthosis versus no orthosis after surgery for spine fractures

  This study is testing whether wearing a brace after spine surgery helps people with fractures feel less pain compared to those who don’t wear one.

  Recruiting Amsterdam UMC, location VUmc · Amsterdam, North Holland · NCT03097081

Quick answers

How many clinical trials run by Amsterdam UMC, location VUmc are recruiting right now?

48, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in Netherlands (48 trials), Finland (1 trial), Germany (1 trial), Portugal (1 trial), Serbia (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 4: 4, Phase 1/2: 3, Phase 3: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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