Combining brain stimulation and cognitive training to improve thinking skills in glioma patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the feasibility of using a combination of cognitive strategy training (CST) and repetitive transcranial magnetic stimulation (rTMS) to address cognitive impairment in adults diagnosed with glioma. Participants will receive either real or sham rTMS alongside cognitive training aimed at enhancing their cognitive abilities. The study is part of a larger project focused on improving the quality of life for brain tumor patients. The goal is to assess the effectiveness of this dual approach in reducing cognitive deficits associated with glioma.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ≥ 18 years of age
* Histological diagnosis of diffuse glioma (WHO grade 2,3, or 4)
* Subjective cognitive impairment, defined as CFQ-score ≥ 44
* Being able to give informed consent and undergo treatment and measurements based on researchers insight
* Stable disease, i.e. no oncological treatment for ≤ 2 months prior to inclusion; no radiological progression on the most recent MRI, not older than 6 months, and no clinical progression at inclusion
* Stable dosage (for at least 8 weeks) of anti-epileptic medication

Exclusion Criteria:

* Current pregnancy or have given birth less than three months ago
* Current other treatment for cognitive complaints
* Karnofsky performance score \<70
* A tumor located in the parietal cortex
* TMS exclusion: implanted medical devices (e.g. pacemaker, deep brain stimulator, cochlear implants, medical infusion device, etc.); metal in the body; sleep deprivation
* MRI exclusion: extreme claustrophobia or metallic objects in or on the body

Where it's running

• VU University Medical Centers, location VUmc
  Amsterdam, Netherlands Recruiting

Study contacts

• Principal investigator: Linda Douw, PhD — Amsterdam UMC, location VUmc
• Study coordinator: Maxine Gorter, MSc
• Email: gripopcognitie@amsterdamumc.nl
• Phone: +31615413273

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.