Treatment for Multiple Sclerosis Using Stem Cell Transplantation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the long-term effects of autologous hematopoietic stem cell transplantation (aHSCT) in patients with highly active relapsing-remitting multiple sclerosis. Participants will undergo regular evaluations over five years, including clinical tests, questionnaires, MRI scans, and blood sampling to monitor disease activity, safety, and immune system changes. The study follows patients approved for aHSCT treatment in the Netherlands, adhering to specific eligibility criteria.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* All patients approved for treatment with aHSCT in the Netherlands in accordance with the Dutch criteria for aHSCT treatment for RRMS

Exclusion Criteria:

* Contra-indications for treatment with aHSCT such as known hypersensitivity to the medication used for aHSCT
* Clinically relevant comorbidities preventing safe use of medication used for aHSCT
* Severe clinical depression
* Active addiction to drugs or alcohol
* Active infections such as but not limited to tuberculosis, cytomegalovirus, Epstein-Barr virus, herpes simplex, varicella zoster, viral hepatitis, toxoplasmosis, HIV or syphilis.
* Active malignancy or history of malignancy with the exception of local basal cell carcinoma or carcinoma in situ of the cervix

Where it's running

• Amsterdam UMC
  Amsterdam, Netherlands Recruiting
• St. Antonius Hospital
  Nieuwegein, Netherlands Recruiting

Study contacts

• Principal investigator: J. Killestein, MSc, PhD — Amsterdam UMC
• Study coordinator: Rick Heijnen, MSc
• Email: r.m.heijnen@amsterdamumc.nl
• Phone: +31627228507

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.