Does a 5-second ventilation pause improve ventilation success in mechanical chest compressions?

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter randomized trial compares two settings for a mechanical chest compression device (LUCAS 3.1) during CPR for out-of-hospital cardiac arrest. Participants are adults 16 and older treated by ambulance personnel, with the device configured to either a 3-second or a 5-second pause for ventilations. The primary outcome is the proportion of ventilation pauses in which two ventilations are delivered. The study uses real-world ambulance settings and linked signal data to assess pause integrity and ventilation success. Leading investigators are from Amsterdam UMC (VUmc) with participating ambulance services in Amsterdam and Kennemerland.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults (≥16 years of age)
* OHCA patients with an attempt at cardiopulmonary resuscitation (CPR) by ambulance personnel
* LUCAS® 3.1 has been used during the resuscitation attempt

Exclusion Criteria:

* Missing ambulance run report, missing or unclear impedance signal (measurement of resistance across the thorax), making it impossible to assess the number of ventilation pauses
* Absence of a minimum of 3 assessable pauses intended for ventilation after connecting the LUCAS®

Where it's running

• Ambulance Amsterdam
  Amsterdam, North Holland, Netherlands Recruiting
• Regionale Ambulance Voorziening Kennemerland - Ambulancezorg GGD Kennemerland
  Haarlem, North Holland, Netherlands Recruiting

Study contacts

• Principal investigator: Patrick Schober, MD, PhD — Amsterdam UMC
• Study coordinator: Lotte C Doeleman, MD
• Email: l.c.doeleman@amsterdamumc.nl
• Phone: +31205665969

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.